Protein Alignment pie and Kmt2a

DIOPT Version :9

• Sequence 1: NP_001260348.1
• Gene: pie / 44315
• FlyBaseID: FBgn0005683
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_038938273.1
• Gene: Kmt2a / 315606
• RGDID: 1586165
• Length: 3986
• Species: Rattus norvegicus
• Alignment Length: 589
• Identity: 128/589 - (21%)
• Similarity: 205/589 - (34%)
• Gaps: 173/589 - (29%)

  Fly     1 MEDNKELQCLIC-KYSDTDDLVFGEWMIV-RNLQVHYFCLLLSTHLPQRGGDSSGILGFLLRDIR 63
            ::||:  ||.:| .|.|......|..:.: :|...|..|.|.|..:.:   |..|    .|:::.
  Rat  1888 IDDNR--QCALCLMYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFE---DDDG----SLKNVH 1943

  Fly    64 EEAAAAEKRKCWYCNKIGASLQC--DRCRSLFHLKCGLENRAVFEFCGQYKSYCYKCRPMDDYKR 126
            ......::.:|.:|.|.||::.|  ..|.|.:|..|......|  |....|.||.:.|  |..|.
  Rat  1944 MAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCV--FLDDKKVYCQRHR--DLIKG 2004

  Fly   127 QLQSNPPRNATCPICFSSIYKV--------------------ELHCVVYG---DC---------C 159
            ::   .|.|.     |....:|                    .:|.::..   ||         |
  Rat  2005 EV---VPENG-----FEVFRRVFVDFEGISLRRKFLNGLEPESVHVMIGSMTIDCLGILNDLSDC 2061

  Fly   160 R-----LGFAHKKCMRQYALTSGYYLRCIW-CRSERFRDSIRLQSVFVPDRDATWEKQRNAYREL 218
            .     :|:   :|.|.|..|:....||:: |:....|     ..|..||.::|.|
  Rat  2062 EDKLFPIGY---QCSRVYWSTTDARKRCVYTCKIMECR-----PPVVEPDINSTVE--------- 2109

  Fly   219 HERNLKCDQPNCLCPSGRT--YNRLSWVILCCSSCAATSAHLKCLVGALRLPKKRERTDFKCSMC 281
            |:.|             ||  ::..|::...|....:|:|.|.  ..:...|:.:..:...|.:.
  Rat  2110 HDDN-------------RTIAHSPSSFIEASCKDSQSTAAILS--PPSPDRPRSQASSSCYCHVI 2159

  Fly   282 LDVER------------------RIAEGPARTTEETNADGDNQVDGSFYVQKLGPDA-ATRSLT- 326
            ..|.|                  ..|..|..||.|....||..:...  ::.:|... :|.||:
  Rat  2160 SKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSG--LRSIGSRRHSTSSLSP 2222

  Fly   327 -------QTPVFSEEDESERSSNITV----IFSQPKSNA----------TSERLSLSPP----QE 366
                   .:||.|....| |||..:|    ..:.|:|:|          :|..|..|.|    .:
  Rat  2223 LRSKLRIMSPVRSGSVYS-RSSVSSVPSLGTATDPESSAKATDRAGPLNSSANLGHSTPVSSGSQ 2286

  Fly   367 EMIVEIPDSPEASPKTSIDENHSPQPIARRDTSD-SPQPIA---------ASEIPD-SPQPTAAS 420
            ..:|      ....|||..:..|...:.|...|| :|:..:         .|:..| |...||.|
  Rat  2287 RTVV------TGGSKTSHLDGSSSSGVKRSSASDLAPKGSSLKGEKNRTPGSKSTDGSAHNTAYS 2345

  Fly   421 EIPDL-PQTTAINVNPELTQQTAL------NTIPHSPQPEASFSTQLVSQTFDCPQPQE--QAVA 476
            .||.| ||  .:|..|.....:.:      :|:|.|.:..:.....|..|..|..|..:  |:|.
  Rat  2346 GIPKLAPQ--VLNAAPGELNVSKIGTFAEPSTVPFSKETVSYPQLHLRGQRSDRDQHMDSTQSVK 2408

  Fly   477 KAPN 480
            .:||
  Rat  2409 PSPN 2412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pie	NP_001260348.1	PHD_SF	9..117	CDD:304600	28/111 (25%)
		PHD_SF	224..>260	CDD:304600	7/37 (19%)
		PARM	318..>491	CDD:293666	51/210 (24%)
Kmt2a	XP_038938273.1	zf-CXXC	1145..1192	CDD:366873
		PHD1_KMT2A	1451..1497	CDD:277063
		PHD2_KMT2A	1499..1548	CDD:277065
		PHD3_KMT2A	1586..1645	CDD:277067
		Bromo_ALL-1	1668..1798	CDD:99925
		ePHD_KMT2A	1892..2004	CDD:277163	31/124 (25%)
		FYRN	2045..2092	CDD:399155	11/49 (22%)
		FYRC	3686..3769	CDD:197781
		SET_KMT2A_2B	3833..3986	CDD:380947

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910