DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pie and Smurf2

DIOPT Version :9

Sequence 1:	NP_001260348.1	Gene:	pie / 44315	FlyBaseID:	FBgn0005683	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001100531.1	Gene:	Smurf2 / 303614	RGDID:	1310067	Length:	748	Species:	Rattus norvegicus

Alignment Length:	500	Identity:	99/500 - (19%)
Similarity:	148/500 - (29%)	Gaps:	184/500 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 DCCRLGFAHKKCMRQYAL----------TSGYYLRCIWCRSERFRDSIRLQSVFVPDRDATWEKQ 211
            |.|:||......:|...:          |.|..:.|    |..|.:.:       ||   .||::
  Rat   116 DLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDC----SRLFDNDL-------PD---GWEER 166

  Fly   212 RNA-----YRELHERNLKCDQPNCLCPSGRTYNRLSWVILCCSSCAATSAHLKCLV--------- 262
            |.|     |.....|..:.::|.  .|:              |..::....|.|.|
  Rat   167 RTASGRIQYLNHITRTTQWERPT--RPA--------------SEYSSPGRPLSCFVDENTPITGT 215

  Fly   263 -GAL-------RLPKKRERT----DFKCSMCLDVERRIAEG-PARTTEETNADGDNQVDGSFYVQ 314
             ||.       ||.::|.|:    ::.....|.....:.|| ..|||::          |..|..
  Rat   216 NGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQ----------GQVYFL 270

  Fly   315 KLGPDAATRSLTQTPVFSEEDESERSSNITVIFSQPK-----SNATSERLSLSPPQEEM------ 368
            .          |||.|.:..|              |:     ||...|.|...||..|:
  Rat   271 H----------TQTGVSTWHD--------------PRVPRDLSNINCEELGPLPPGWEIRNTATG 311

  Fly   369 ----------IVEIPDSPEASPKTSIDENHSPQPIARRDTSDSPQPIAASEIPDSPQPTAASEIP 423
                      ..:..| |..|....:..|...|      ..|..|....|..||.   |....:|
  Rat   312 RVYFVDHNNRTTQFTD-PRLSANLHLVLNRQNQ------LKDQQQQQVVSLCPDD---TECLTVP 366

  Fly   424 ----DLPQTTAINVNPELTQQTALNTIPHSPQPEASFSTQLVSQTFDCPQPQEQAVAKAPNSPSL 484
                ||.|...| :..||:||          ||:|......||:.....:...|.:...|
  Rat   367 RYKRDLVQKLKI-LRQELSQQ----------QPQAGHCRIEVSREEIFEESYRQVMKMRP----- 415

  Fly   485 PKEDPNTLLVLK----SGFQCPG--EPFFYLVIYEFEHGTCMGECIGTCVLRFKEDDPRIQDTSQ 543
              :|....|::|    .|....|  ..:.||:.:|.     :....|  :.::..||
  Rat   416 --KDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEM-----LNPYYG--LFQYSRDD-------- 463

  Fly   544 AALERVNITPDDVWCRSEDRGIFEHIEK------FHEWYRSEGFS 582
              :..:.|.||.. ...|....|..:.:      ||..|...||:
  Rat   464 --IYTLQINPDSA-VNPEHLSYFHFVGRIMGMAVFHGHYIDGGFT 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pie	NP_001260348.1	PHD_SF	9..117	CDD:304600
		PHD_SF	224..>260	CDD:304600	4/35 (11%)
		PARM	318..>491	CDD:293666	41/197 (21%)
Smurf2	NP_001100531.1	C2_Smurf-like	13..137	CDD:176028	5/20 (25%)
		PRP40	155..>236	CDD:227435	21/106 (20%)
		WW	159..188	CDD:395320	8/38 (21%)
		WW	252..283	CDD:197736	12/64 (19%)
		WW	298..330	CDD:197736	5/32 (16%)
		HECTc	393..745	CDD:238033	25/137 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910