DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pie and G2e3

DIOPT Version :9

Sequence 1:	NP_001260348.1	Gene:	pie / 44315	FlyBaseID:	FBgn0005683	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001161435.1	Gene:	G2e3 / 217558	MGIID:	2444298	Length:	739	Species:	Mus musculus

Alignment Length:	363	Identity:	108/363 - (29%)
Similarity:	176/363 - (48%)	Gaps:	53/363 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDNK-----ELQCLICKYSDTDDLVFGE------WMIVRNLQVHYFCLLLSTHLPQRGGDSSGI 54
            |.:||     .|.|:.|:.:|.....:||      |    |..|||:|||:|:.:.|||.:..|:
Mouse     1 MNENKPDNSQSLACVFCRKNDDCPNKYGEKKTYEKW----NFSVHYYCLLMSSGIWQRGKEEEGV 61

  Fly    55 LGFLLRDIREEAAAAEKRKCWYCNKIGASLQC--DRCRSLFHLKCGLENRAVFEFCGQYKSYCYK 117
            .|||:.|||:|...|.|.||..|.|.|||:.|  ..|:..:||.|||:...:|:|...:.|:|:|
Mouse    62 YGFLIEDIRKEVQRASKLKCTVCKKNGASIGCVVPTCKRSYHLPCGLQKECIFQFTDNFASFCWK 126

  Fly   118 CRPMDDYKRQLQSNP-PRNATCPICFSSIYKVELHCVVYGDCCRLGFAHKKCMRQYALTSG-YYL 180
            .||:    :.:.||. ..:..|.||...:..:..:.::...||:..:.|:.|::..|:.:| ::.
Mouse   127 HRPV----QAITSNKYSSSLPCTICLEFVEPIPTYNILQSPCCKNAWFHRDCLQVQAINAGVFFF 187

  Fly   181 RCIWC-RSERFRDSIRLQSVFVPDRDATWEKQRNAYRELHERNLKCDQPNCLCPSGRTYN--RLS 242
            ||..| .::.|:..:....:.:|::||:||.:.|||:||.:.:.:||...|.|..||.||  ...
Mouse   188 RCTLCNNTDIFQKEMLRMGIHIPEKDASWELEENAYQELLQSHDRCDIRRCHCKKGRDYNEPNSK 252

  Fly   243 WVILCCSSCAATSAHLKCLVGALRLPKKRERTDFKCSMCLDVERRIAEGPARTTEETNADGDNQV 307
            |.:..|.||.::..||.|  .:|:..::    :::|..|    |||.                 .
Mouse   253 WEVKRCQSCGSSGTHLAC--SSLQSWEQ----NWECLDC----RRIT-----------------Y 290

  Fly   308 DGSFYVQKLGPDAATRSLTQTPVFSEEDESERSSNITV 345
            ...|......|.|.:.::|.|....||..|:.....||
Mouse   291 TSDFQKAPKHPLANSTNVTVTDCLLEESSSKLPRQSTV 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pie	NP_001260348.1	PHD_SF	9..117	CDD:304600	45/115 (39%)
		PHD_SF	224..>260	CDD:304600	14/37 (38%)
		PARM	318..>491	CDD:293666	9/28 (32%)
G2e3	NP_001161435.1	ePHD_PHF7_G2E3_like	14..127	CDD:277139	45/116 (39%)
		PHD_PHF7_G2E3_like	232..285	CDD:276971	17/58 (29%)
		HECTc	388..704	CDD:294058
		HECTc	411..713	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831378
Domainoid	1	1.000	94	1.000	Domainoid score	I7456
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003998
OrthoInspector	1	1.000	-	-		otm43314
orthoMCL	1	0.900	-	-		OOG6_106451
Panther	1	1.100	-	-	O	PTHR12420
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3283
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.740