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Protein Alignment pie and Kmt2a

DIOPT Version :9

Sequence 1:	NP_001260348.1	Gene:	pie / 44315	FlyBaseID:	FBgn0005683	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001344478.1	Gene:	Kmt2a / 214162	MGIID:	96995	Length:	3966	Species:	Mus musculus

Alignment Length:	589	Identity:	125/589 - (21%)
Similarity:	203/589 - (34%)	Gaps:	174/589 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDNKELQCLIC-KYSDTDDLVFGEWMIV-RNLQVHYFCLLLSTHLPQRGGDSSGILGFLLRDIR 63
            ::||:  ||.:| .|.|......|..:.: :|...|..|.|.|..:.:   |..|    .|:::.
Mouse  1869 IDDNR--QCALCLMYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFE---DDDG----SLKNVH 1924

  Fly    64 EEAAAAEKRKCWYCNKIGASLQC--DRCRSLFHLKCGLENRAVFEFCGQYKSYCYKCR------- 119
            ......::.:|.:|.|.||::.|  ..|.|.:|..|......|  |....|.||.:.|
Mouse  1925 MAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCV--FLDDKKVYCQRHRDLIKGEV 1987

  Fly   120 -PMDDY----------------KRQLQSNPPRNATCPICFSSIYKVELHCVVYG---DC------ 158
             |.:.:                ::.|....|.|              :|.::..   ||
Mouse  1988 VPENGFEVFRRVFVDFEGISLRRKFLNGLEPEN--------------IHMMIGSMTIDCLGILND 2038

  Fly   159 ---CR-----LGFAHKKCMRQYALTSGYYLRCIW-CRSERFRDSIRLQSVFVPDRDATWEKQRNA 214
               |.     :|:   :|.|.|..|:....||:: |:....|     ..|..||.::|.|
Mouse  2039 LSDCEDKLFPIGY---QCSRVYWSTTDARKRCVYTCKIMECR-----PPVVEPDINSTVE----- 2090

  Fly   215 YRELHERNLKCDQPNCLCPSGRT--YNRLSWVILCCSSCAATSA--------------------H 257
                |:.|             ||  ::..|::...|....:|:|                    |
Mouse  2091 ----HDDN-------------RTIAHSPSSFIDASCKDSQSTAAILSPPSPDRPHSQTSGSCYYH 2138

  Fly   258 LKCLVGALRLPKKRERTDFKCSMCLDVERRIAEGPARTTEETNADGDNQVDGSFYVQKLGPDA-A 321
            :...|..:|.|......  :...|..:..  |..|..||.|....||..:...  ::.:|... :
Mouse  2139 VISKVPRIRTPSYSPTQ--RSPGCRPLPS--AGSPTPTTHEIVTVGDPLLSSG--LRSIGSRRHS 2197

  Fly   322 TRSLT--------QTPVFSEEDESERSSNITV----IFSQPKSNA-TSERLSLSPPQEEMIVEIP 373
            |.||:        .:||.:....| |||..:|    ..:.|:::| .|:|..|......:....|
Mouse  2198 TSSLSPLRSKLRIMSPVRTGSAYS-RSSVSSVPSLGTATDPEASAKASDRGGLLSSSANLGHSAP 2261

  Fly   374 DSPEA-----SPKTSIDENHSPQPIARRDTSD-SPQPIAASEIPDSPQPTAASEIPD-LPQTTAI 431
            .|..:     ..|||..:..||..:.|...|| .|:   .|.:......|::|:..| ...:||.
Mouse  2262 PSSSSQRTVGGSKTSHLDGSSPSEVKRCSASDLVPK---GSLVKGEKNRTSSSKSTDGSAHSTAY 2323

  Fly   432 NVNPELTQQT------ALN-----------TIPHSPQPEASF-STQLVSQTFDCPQPQE--QAVA 476
            ...|:||.|.      .||           |:|.|.:...|: ...|..|..|..|..:  |:|.
Mouse  2324 PGIPKLTPQVHNATPGELNISKIGSFAEPSTVPFSSKDTVSYPQLHLRGQRSDRDQHMDPSQSVK 2388

  Fly   477 KAPN 480
            .:||
Mouse  2389 PSPN 2392

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.