Protein Alignment pie and Tcf20

DIOPT Version :9

• Sequence 1: NP_001260348.1
• Gene: pie / 44315
• FlyBaseID: FBgn0005683
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001107612.1
• Gene: Tcf20 / 21411
• MGIID: 108399
• Length: 1987
• Species: Mus musculus
• Alignment Length: 412
• Identity: 83/412 - (20%)
• Similarity: 127/412 - (30%)
• Gaps: 163/412 - (39%)

  Fly   202 PDRDATWEKQRNAYREL-HERNLKC--------DQPNCLCPSGRTYNRLSWVILCCSSCAATS-- 255
            |.::.. :|..|:|..| |.:::|.        |.||   |..|.          |.:...||
Mouse  1315 PSKEGA-DKAYNSYSHLSHSQDIKSIPKRDSSKDLPN---PDNRN----------CPAVTLTSPA 1365

  Fly   256 ------------AHLKCLVGALRLPKKR------------------------------------- 271
                        ..|:.:|..:..|..|
Mouse  1366 KTKILPPRKGRGLKLEAIVQKITSPNIRRSASANSAEAGGDTVTLDDILSLKSGPPEGGTVATQE 1430

  Fly   272 -ERTDFKCSMCLD----------VERRIAEGPARTTEETNADGDNQVDGSFYVQKLGPDAATRSL 325
             |....||.:..|          ||:.: .||   :||....||::|....:|:       |.|.
Mouse  1431 AEMEKRKCEVVSDLVSVTNQESNVEKPL-PGP---SEEWRGSGDDKVKTEAHVE-------TAST 1484

  Fly   326 TQTPVFSEEDESERSSNITVIFSQ-PKSNATSERLSL--SPPQEEMIVEIPDS----------PE 377
            .:.|          |..:|...|| |..|......||  :.|     :..|||          ||
Mouse  1485 GKEP----------SGTMTSTASQKPGGNQGRPDGSLGGAAP-----LIFPDSKNVAPVGILAPE 1534

  Fly   378 ASPKTSIDENHSPQPIARRDTSDSP-----------QPIAA--------SEIPDSPQPTAASEIP 423
            |:||....||.:.. |:.:..|..|           :||.:        .:.|..|||      |
Mouse  1535 ANPKAEEKENDTVM-ISPKQESFPPKGYFPSGKKKGRPIGSVNKQKKQQQQPPPPPQP------P 1592

  Fly   424 DLPQTTAINVNPELTQQTALNTIPHSPQPEASFSTQLVSQTFDCPQPQEQAVAKAPNSPSLPKED 488
            .:|:.:| :..|:..:|....   ...:|.|....:...|.....:|||..:.....:..|.|.|
Mouse  1593 QMPEGSA-DGEPKPKKQRQRR---ERRKPGAQPRKRKTKQAVPIVEPQEPEIKLKYATQPLDKTD 1653

  Fly   489 PNTLLVLKSGFQCPGEPFFYLV 510
            ...    ||.|     |:.::|
Mouse  1654 AKN----KSFF-----PYIHVV 1666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pie	NP_001260348.1	PHD_SF	9..117	CDD:304600
		PHD_SF	224..>260	CDD:304600	10/57 (18%)
		PARM	318..>491	CDD:293666	45/204 (22%)
Tcf20	NP_001107612.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..79
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	96..432
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..481
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	502..816
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	844..891
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	949..1065
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1136..1372		15/70 (21%)
		Leucine-zipper	1198..1219
		Nuclear localization signal	1282..1295
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1415..1434		1/18 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1446..1636		49/226 (22%)
		Nuclear localization signal	1604..1628		3/26 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1685..1710
		ePHD_TCF20	1733..1959	CDD:277169
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1760..1865
		Nuclear localization signal	1812..1819
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1966..1987

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900