DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pie and g2e3

DIOPT Version :9

Sequence 1:	NP_001260348.1	Gene:	pie / 44315	FlyBaseID:	FBgn0005683	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_002932878.1	Gene:	g2e3 / 100496302	XenbaseID:	XB-GENE-999810	Length:	700	Species:	Xenopus tropicalis

Alignment Length:	589	Identity:	143/589 - (24%)
Similarity:	240/589 - (40%)	Gaps:	141/589 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EDNKELQCLICKYSDTDDLVFGEWMIV--RNLQVHYFCLLLSTHLPQRGGDSSGILGFLLRDIRE 64
            :.:|.|.|:.|..||.....|||....  .:|.:||:|||||:.:.|||.::.||.|||:.||::
Frog     7 KSSKNLPCVFCGLSDDCAEKFGEKKTYPEHDLTLHYYCLLLSSGIWQRGKENEGIYGFLVCDIKK 71

  Fly    65 EAAAAEKRKCWYCNKIGASLQC--DRCRSLFHLKCGLENRAVFEFCGQYKSYCYKCRPMDDYKRQ 127
            |...|.|.:|..|...|||:.|  .:||..:|..||::...:|:|...::|||::.||:   ::.
Frog    72 EVNRANKLRCALCKNRGASIGCVFPKCRRSYHYHCGVKKECIFQFTDSFRSYCWEHRPV---QKI 133

  Fly   128 LQSNPPRNATCPICFSSIYKVELHCVVYGDCCRLGFAHKKCMRQYALTSG-YYLRCIWCRS-ERF 190
            :.|....::||.||..::..|..:.::...||:..:.|:.|::..||::| ::.||..|.: :.|
Frog   134 VSSQTDCSSTCTICLENVNHVSSYHILRSPCCKTSWFHRNCLQHQALSAGLFFFRCTVCNNKDIF 198

  Fly   191 RDSIRLQSVFVPDRDATWEKQRNAYRELHERNLKCDQPNCLCPSGRTYN--RLSWVILCCSSCAA 253
            ::.:....:.:|:|||:||.:.||::||..|..:||...|:|..||.||  ...|.|:.|..|.:
Frog   199 QNEMLRMGIHIPERDASWELEENAFQELLVRYQRCDAKKCVCRGGREYNEPENKWEIVRCQCCGS 263

  Fly   254 TSAHLKC-LVGALRLPKKRERTDFKCSMCLDVERRIAEGPARTTEETNADGDNQVDGSFYVQKLG 317
            :..|..| .:|.|       ...::|..|..|                            |...|
Frog   264 SGTHRACSSIGEL-------DQSWECPDCCSV----------------------------VSTPG 293

  Fly   318 PDAATRSLTQTPVFSEEDESERSSNITVIFSQPKSNATSERLSLSPPQEEMIVEIPDSPEASPKT 382
            ..:...||.|            |..:..:....:|:....|||.:|..:.::..|    ....:|
Frog   294 KRSRPASLAQ------------SDQLGCLGFGMESSPKCPRLSTTPKGKVLLRHI----STQERT 342

  Fly   383 SIDENHSPQPIARRDTSDSPQPIAASEIPDSPQPTAASEIPDLPQTTAINVNPELTQQTALNTIP 447
            ..|..|:   :..:..:||                          ...:.:..|...|::|....
Frog   343 ISDILHN---LRLQINTDS--------------------------VCTMLIQKECLWQSSLECFR 378

  Fly   448 HSP-QPEASFSTQLVSQTF--DCPQPQEQ-------AVAKAPNSPSLPKEDPNTL---------- 492
            :|. .|.::...:.....|  :|.||...       .:....|||.|...:...:
Frog   379 NSNFCPSSTLRVKFTKHKFRMECKQPNGSLSEYFGLLLNTVRNSPLLEGSEHKNIALNLEALEDN 443

  Fly   493 ----------LVLKSGFQCPG---EPFFYLVIYEFEHGTCMGECIGTCVLRFKED--DPRIQDTS 542
                      |.|..|...||   :..|..:||:.:|           ||...||  ||.:   :
Frog   444 LYFEAGRMVALALVHGGPAPGFFSQTLFRCLIYDPQH-----------VLPAVEDVADPNV---A 494

  Fly   543 QAAL 546
            ||.|
Frog   495 QAIL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pie	NP_001260348.1	PHD_SF	9..117	CDD:304600	44/111 (40%)
		PHD_SF	224..>260	CDD:304600	13/37 (35%)
		PARM	318..>491	CDD:293666	28/182 (15%)
g2e3	XP_002932878.1	ePHD_PHF7_G2E3_like	14..127	CDD:277139	44/112 (39%)
		PHD_PHF7_G2E3_like	232..285	CDD:276971	17/59 (29%)
		HECTc	436..682	CDD:391658	18/77 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8212
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110264at33208
OrthoFinder	1	1.000	-	-		FOG0003998
OrthoInspector	1	1.000	-	-		oto103661
Panther	1	1.100	-	-	O	PTHR12420
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3283
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.020