Protein Alignment MYO1B and MYO3

DIOPT Version :9

• Sequence 1: NP_001123630.1
• Gene: MYO1B / 4430
• HGNCID: 7596
• Length: 1136
• Species: Homo sapiens
• Sequence 2: NP_012793.2
• Gene: MYO3 / 853729
• SGDID: S000001612
• Length: 1272
• Species: Saccharomyces cerevisiae
• Alignment Length: 1226
• Identity: 377/1226 - (30%)
• Similarity: 599/1226 - (48%)
• Gaps: 259/1226 - (21%)

Human     5 EVKTSLLD----NMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYS 65
            ::|.:..|    ..:|:.|:.||..:::|:...||||||.:..||||||.|:|||||:|.|.||:
Yeast    22 KIKKATFDANKKKEVGISDLTLLSKISDESINENLKKRFKNGIIYTYIGHVLISVNPFRDLGIYT 86

Human    66 PEKVEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCG 130
            ...:|.|:.:|..|:.||:||:::..|.:|:..:::||::|:||||||||||:|.:|.|:||...
Yeast    87 NAVLESYKGKNRLEVPPHVFAIAESMYYNLKSYNENQCVIISGESGAGKTEAAKRIMQYIAAASN 151

Human   131 KGAE-VNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSR 194
            ..:| :.::|:.:|.:||:||:||.|||:||:||||.|||::|:|:.:.:|..|.|:||||||.|
Yeast   152 SHSESIGKIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIKFNSQFEPCAGNITNYLLEKQR 216

Human   195 VVKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNY-LSLDSAKVNGVDDAANFRTVRNAM 258
            ||.|.:.|||||:|||...|||:.......::.. .:|.| .:......:.:||..::.....||
Yeast   217 VVGQIKNERNFHIFYQFTKGASDTYKQMFGVQMP-EQYIYTAAAGCTTADTIDDVKDYEGTLEAM 280

Human   259 QIVGFMDHEAESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERA 323
            :.:|.:..|.:.:..::||:|.:|||.|......|    :::.|.:....:..|..:|.|:|.:.
Yeast   281 RTIGLVQEEQDQIFRMLAAILWIGNISFIENEEGN----AQVGDTSVTDFVAYLLQVDASLLVKC 341

Human   324 FSFRTVEA----KQEKV-STTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVM 383
            ...|.::.    |:..| ...||..||...||||||.:|:.||.|:|:|:|.|::|.....|.:
Yeast   342 LVERIMQTSHGMKRGSVYHVPLNPVQATAVRDALAKAIYNNLFDWIVDRVNVSLQAFPGADKSI- 405

Human   384 GVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDL 448
            |:||||||||||.|||||..|||.|||||||||:||||.|||.|.||.|:||.|.||:|.::|||
Yeast   406 GILDIYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLKAEQETYEREKIKWTPIKYFDNKVVCDL 470

Human   449 IE-NNTNGILAMLDEECL---RPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSC 509
            || .|..||||.:::...   ......|:.|.::|| :..::.:||.|.:|
Yeast   471 IEAKNPPGILAAMNDSIATAHADSNAADQAFAQRLN-LFNSNPYFELRANK-------------- 520

Human   510 FRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKASHALIKSLFPEGNPAKINLKRPPTAGSQF 574
            |.|:||||.|.|.:.|..|||.|.|.:||.:.:...::..:.::||: :..|.:.:||||||.:.
Yeast   521 FVIKHYAGDVTYDINGITDKNKDQLQKDLIELIGTTTNTFLSTIFPD-DVDKDSKRRPPTAGDKI 584

Human   575 KASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAYE 639
            ..|...|::.|....|:|||.||||..|:.:.:::..|.||::||||.||||:||||:|:||.:|
Yeast   585 IKSANELVETLSKAEPSYIRTIKPNQTKSPNDYDDHQVLHQVKYLGLQENVRIRRAGFAYRQTFE 649

Human   640 PCLERYKML---CKQTWPH-WKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLR 700
            ..:||:.:|   |.....: |.|.....|:::..:..||.:|:..|.:.:||:.|.:||.|||:|
Yeast   650 KFVERFYLLSPDCSYAGDYTWDGDTLEAVKLILRDAMIPEKEFQLGVTSVFIKTPESLFALEDMR 714

Human   701 KQRLEDLATLIQKIYRGWKCRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIR--- 762
            .:...::|..||:                      || ||:.|::     ..:|:.||..||
Yeast   715 DKYWYNMAARIQR----------------------AW-RRFLQRR-----IDAAIKIQRTIREKK 751

Human   763 -----------------GWKARKILRELKHQK------RCKEAVTTIAAYWHGTQARRELRRLKE 804
                             |.|.|:.:..|.::.      .|.|:.|      .|:..||:: .:|:
Yeast   752 GGNKYVKLRDYGTKLLAGKKERRSMSLLGYRAFMGDYLSCNESKT------KGSYIRRQV-GIKD 809

Human   805 EARNKHAIAVIWAYWLGSKARRELKRLKE-------------EARRKHAVAVIWAYWLGLKVRRE 856
            :     .:..|....|.||..|..:|||:             :.|.::|:              :
Yeast   810 K-----VVFSIKGECLHSKFGRSAQRLKKVFILTKKTFYIIGQTREQNAM--------------K 855

Human   857 YRKFFRANAGKKIYEFTLQRIVQKYF-------------------LEMKNKMPSLSP--IDKNWP 900
            |.:.::.:.| ||.:.:|..:...:.                   .|:..::..|:.  :.|..|
Yeast   856 YTQDYKIDVG-KIKQVSLTNLQDDWMGVILVNSTQSDPLINTPFKTELMTRLKKLNEKIMIKVGP 919

Human   901 SRPYLFLDSTHKELKRIFHLWRCK------KYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSV 959
            :..|      ||:..:: |..|.|      ||.|.:  :...||..:...:....:||...|..:
Yeast   920 TIEY------HKQPNKL-HTVRSKISDSAPKYGDIY--KSSTIYVRRGHPANSKSNKKPKNPGGL 975

Human   960 -GQPF---------------------------------------------QGAYLEINKNPKYKK 978
             |:|.                                             |.||     |||..|
Yeast   976 SGKPIKSKKSKHKSTHKHTHSHRSHRDAAKKQPLPSQKPVNPLSLAATAAQAAY-----NPKPDK 1035

Human   979 LKDAIEEKIIIAEVVNK------------INRANG--KSTSRIFLLTNNNLLLADQKSGQIKSEV 1029
            ........|..|:|.:|            :.:|:.  ||:|     ...|.:......|..|::.
Yeast  1036 TVPIKSSAIPAAKVSSKHSSKPSSKEKVAVKKASSSHKSSS-----AKQNQVSMPPSKGVEKNKE 1095

Human  1030 PLVDVTKVSMSS-------------QNDGFFAVHLKEGSEAAS-----KGDFLFSS 1067
            ||.:.|..:.::             ::..|.|.:...||.::|     |||.:|.|
Yeast  1096 PLKETTATATANIPIPPPPPPMGQPKDPKFEAAYDFPGSGSSSELPLKKGDIVFIS 1151

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1B	NP_001123630.1	MYSc_Myo1	29..688	CDD:276829	273/673 (41%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	578..600		9/21 (43%)
		IQ	749..771	CDD:197470	8/41 (20%)
		Myosin_TH1	941..1118	CDD:399188	36/205 (18%)
MYO3	NP_012793.2	COG5022	1..1258	CDD:227355	377/1226 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810