Protein Alignment MYO1B and myo1b

DIOPT Version :9

• Sequence 1: NP_001123630.1
• Gene: MYO1B / 4430
• HGNCID: 7596
• Length: 1136
• Species: Homo sapiens
• Sequence 2: XP_005168005.1
• Gene: myo1b / 541515
• ZFINID: ZDB-GENE-030131-695
• Length: 1167
• Species: Danio rerio
• Alignment Length: 1165
• Identity: 934/1165 - (80%)
• Similarity: 1050/1165 - (90%)
• Gaps: 32/1165 - (2%)

Human     4 MEVKTSLLDNMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEK 68
            |||||||||||||||||||||||:||:||.||||||||:||||||||||||:|||:||.|||.||
Zfish     1 MEVKTSLLDNMIGVGDMVLLEPLSEESFIENLKKRFDHNEIYTYIGSVVISMNPYKSLSIYSAEK 65

Human    69 VEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGA 133
            ||||||||||||||||:||:||||||||.||||||||||||||||||||||.||||||||||||.
Zfish    66 VEEYRNRNFYELSPHIYALADEAYRSLRHQDKDQCILITGESGAGKTEASKFVMSYVAAVCGKGQ 130

Human   134 EVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQ 198
            |||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   131 EVNKVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQ 195

Human   199 PRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGF 263
            ||||||||:|||||||||:::|.||||:||||:|||||||||.|||:||||:|||||||||||||
Zfish   196 PRGERNFHIFYQLLSGASDDMLKKLKLDRDFSKYNYLSLDSATVNGLDDAASFRTVRNAMQIVGF 260

Human   264 MDHEAESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERAFSFRT 328
            |:.|.:|:|.::|||||||||||||||||||.|||::||||:|||:|||.||:||||||||||||
Zfish   261 MEDEVQSILELIAAVLKLGNIEFKPESRVNGFDESRVKDKNDLKEMCELLGIEQSVLERAFSFRT 325

Human   329 VEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEI 393
            ||||.||||||||||||||||||||||||||||:|||||||||||||||.|||||||||||||||
Zfish   326 VEAKMEKVSTTLNVAQAYYARDALAKNLYSRLFTWLVNRINESIKAQTKTRKKVMGVLDIYGFEI 390

Human   394 FE--DNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGI 456
            ||  |||||||||||||||||||||||||:|||||||||.||||:|:||||||||||||||.|||
Zfish   391 FENGDNSFEQFIINYCNEKLQQIFIELTLREEQEEYIREGIEWTNIEYFNNAIICDLIENNKNGI 455

Human   457 LAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLY 521
            ||||||||||||||||||||:|||.|||.|||||||:||.|:||.|.||||:|||||||||||||
Zfish   456 LAMLDEECLRPGTVTDETFLDKLNTVCAEHQHFESRLSKNSKFLTDHSLPHNCFRIQHYAGKVLY 520

Human   522 QVEGFVDKNNDLLYRDLSQAMWKASHALIKSLFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQ 586
            :||||||||||||||||||||:||:|.|||.|||||||||:|||||||||.||:|||.||||||.
Zfish   521 RVEGFVDKNNDLLYRDLSQAMYKANHNLIKLLFPEGNPAKVNLKRPPTAGFQFRASVGTLMKNLL 585

Human   587 TKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQ 651
            |||||||||||||||||||||.::|||||:|||||:|||||||||||||||||||||||||||||
Zfish   586 TKNPNYIRCIKPNDKKAAHIFTDSLVCHQVRYLGLMENVRVRRAGYAFRQAYEPCLERYKMLCKQ 650

Human   652 TWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYR 716
            ||||||||||.|||||.::|::|.||:::||||||||||||||.||:.|:|.|||||.|||||||
Zfish   651 TWPHWKGPAREGVEVLLSDLQVPAEEFAYGRSKIFIRNPRTLFFLEEKRRQCLEDLAALIQKIYR 715

Human   717 GWKCRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKARKILRELKHQKRCKE 781
            ||||||||||:||||:|:||||||:||||:||:.:.||||:||:||||||||:||||||:|||:|
Zfish   716 GWKCRTHFLLLKKSQVVVAAWYRRFAQQKKYQKIRCSALVVQSFIRGWKARKLLRELKHKKRCEE 780

Human   782 AVTTIAAYWHGTQARRELRRLKEEARNKHAIAVIWAYWL-------------------------- 820
            |||||:|||||||||.||||||:||.||||::||||.||
Zfish   781 AVTTISAYWHGTQARWELRRLKKEAWNKHAVSVIWAAWLGTKARRELQKLKHEACSKQAVSVIWA 845

Human   821 ---GSKARRELKRLKEEARRKHAVAVIWAYWLGLKVRREYRKFFRANAGKKIYEFTLQRIVQKYF 882
               |:||||||||||||||||||:|||||||||||||||||||||||||||||:||:|||:|||:
Zfish   846 CWQGTKARRELKRLKEEARRKHAIAVIWAYWLGLKVRREYRKFFRANAGKKIYDFTIQRIIQKYY 910

Human   883 LEMKNKMPSLSPIDKNWPSRPYLFLDSTHKELKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASEL 947
            |.:|..|||:|||||:|.:.||.|||.||:||:||||||||||||.|||:::|..|||||.||||
Zfish   911 LGLKKTMPSMSPIDKSWSTCPYGFLDGTHQELRRIFHLWRCKKYRSQFTEEKKATYEEKLAASEL 975

Human   948 FKDKKALYPSSVGQPFQGAYLEINKNPKYKKLKDAIEEKIIIAEVVNKINRANGKSTSRIFLLTN 1012
            ||||||||||||.|||:|.|:||.|||||:||...:|:|:::|:||:||||||||.|.||||||.
Zfish   976 FKDKKALYPSSVSQPFKGDYVEITKNPKYQKLNSLVEDKVLLADVVSKINRANGKGTPRIFLLTK 1040

Human  1013 NNLLLADQKSGQIKSEVPLVDVTKVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKL 1077
            ..|:|||||:||:|:.|||.|::.|.:|:|||||||:.|:||:.:|:|||:|.|||.|||:.|||
Zfish  1041 KCLVLADQKTGQVKASVPLPDLSSVFVSTQNDGFFALKLREGATSAAKGDYLLSSDRLIEIITKL 1105

Human  1078 YRT-TLSQTKQKLNIEISDEFLVQFRQDKVCVKFIQGNQKNGSVPTCKRKNNRLLEVAVP 1136
            |.| ..|..:.::.|:|||||||||:|||||||||||..||.:..:|||||||||||:||
Zfish  1106 YCTGAASAERNQIKIDISDEFLVQFKQDKVCVKFIQGTPKNSNSVSCKRKNNRLLEVSVP 1165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1B	NP_001123630.1	MYSc_Myo1	29..688	CDD:276829	578/660 (88%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	578..600		19/21 (90%)
		IQ	749..771	CDD:197470	14/21 (67%)
		Myosin_TH1	941..1118	CDD:399188	116/177 (66%)
myo1b	XP_005168005.1	MYSc	13..700	CDD:214580	600/686 (87%)
		MYSc_Myo1	26..687	CDD:276829	578/660 (88%)
		Myosin_TH1	969..1142	CDD:283635	113/172 (66%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194336916
Domainoid	1	1.000	1212	1.000	Domainoid score	I232
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7856
Inparanoid	1	1.050	1864	1.000	Inparanoid score	I538
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG53790
OrthoDB	1	1.010	-	-		D105718at33208
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	1	1.000	-	-		oto47736
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9566
SonicParanoid	1	1.000	-	-		X9527
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300