DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ome and Dpp8

DIOPT Version :9

Sequence 1:	NP_001097606.1	Gene:	ome / 44297	FlyBaseID:	FBgn0259175	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_083182.2	Gene:	Dpp8 / 74388	MGIID:	1921638	Length:	892	Species:	Mus musculus

Alignment Length:	962	Identity:	213/962 - (22%)
Similarity:	349/962 - (36%)	Gaps:	266/962 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 RVRIILTVVTTVIAVALLATALVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSWSN 329
            |..:...:.|..:.|.:..||          :.::.:..|.:...||     ..|.:|:  |||.
Mouse     7 RCNMAAAMETEQLGVEIFETA----------ECEEGNGESQDRPKLE-----PFYVERY--SWSQ 54

  Fly   330 GNSLIYKENTSIMEFDAKTGE-RSILLEDAQHYVLYEKSADGEFLLLAKNYKKNFRYSFLAEYDL 393
            ...|:           |.|.: ...::..|.|..::.|..|       .:...:.|..:||....
Mouse    55 LKKLL-----------ADTRKYHGYMMAKAPHDFMFVKRTD-------PDGPHSDRVYYLAMSGE 101

  Fly   394 YNLNTKEFIQLTIQNEQHYLSMVQWSPVGNALVINYDRNLYYKESALAQE------IALTSDE-- 450
            ...||..:.::.....:..:.|:.|.|:.:......|..:|.:|..|.:|      :.:.:.:
Mouse   102 NRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIAAYDYH 166

  Fly   451 --------QAGILNGI--------------------------------------PDWV------- 462
                    |||  :||                                      |||:
Mouse   167 PGSGTFLFQAG--SGIYHIKDGGPHGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSND 229

  Fly   463 -----------------------YEEEVFSSNVAT-------------WF------NPSGTQLAF 485
                                   .||:..|:.|||             |:      .|||.::..
Mouse   230 IWISNLVTREERRITYVHNELANMEEDPRSAGVATFVLQEEFDRYSGYWWCPQAERTPSGGKILR 294

  Fly   486 IKF---DDSSTHLINFPYYGDAGDLRYQYPLHQV-----IAYPKAGSSNPRVELVMVDLKRAVAG 542
            |.:   |:|...:|:           ...|:.:.     ..|||.|::||:|...|.::....||
Mouse   295 ILYEENDESEVEIIH-----------VTSPMLETRRADSFRYPKTGTANPKVTFKMSEIVVDAAG 348

  Fly   543 G-----DFVTVMPVPSALNTETDYIVTVVSWV-DDDNVLSIWMNRIQNAAYVVTF---------- 591
            |     |...|.|. ..|....:||.. ..|. :..:..||.::|.|....:|..
Mouse   349 GIIDVIDKELVQPF-EILFEGVEYIAR-AGWTPEGKHAWSILLDRSQTHLQIVLISPELFIPVED 411

  Fly   592 DGLNRK-------------VIYSAESKTGWVDLYTA--PFRNRNGSRLAFVLP---HNNYKHVQL 638
            |.::|:             :||. |:...|::::..  .|...:...:.|:..   ...::|:..
Mouse   412 DAMDRQRLIESVPDSVTPLIIYE-ETTDIWINIHDIFHVFPQTHEDEIEFIFASECKTGFRHLYK 475

  Fly   639 LSSTVASSE----------PQALE-------PLTEGKYVV-----DSILHWDGKNDIIFYTANTE 681
            ::|.:..|:          |...:       .:|.|::.|     .:|  |..:...:.|...|:
Mouse   476 ITSILKESKYKRSSGGLPAPSDFKCPIKEEITITSGEWEVLGRHGSNI--WVDEARKLVYFEGTK 538

  Fly   682 DHPEQLHLYAIRALAKQSPKCLT-------CNLIKSGDVQQTYFSATFND--NNHIVITSLGPGI 737
            |.|.:.|||............||       |.|.:..|    :|.:.:::  |.|.|
Mouse   539 DSPLEHHLYVTSYANPGEVVRLTDRGYSHSCCLSRHCD----FFISKYSNQKNPHCV-------- 591

  Fly   738 PTTHIYEWKYENSQVVISKVLDWETNESLRAKLKGVALPSHKILTVDIDGGFQAKVLLQLPPNLD 802
               .:|:........|......|.|.......|.....|  :|.:.:...||....:|..|.:|.
Mouse   592 ---SLYKLSSPEDDPVHKTKEFWATILDSAGPLPDYTPP--EIFSFESTTGFTLYGMLYKPHDLQ 651

  Fly   803 TSGATKYPMLVDVYGGPDSYSVTNKWMVDWGT-YLSSNQ----SVIYAKIDGRGSGLRGESLLHA 862
            .  ..|||.::.:||||....|.|::.   |. |...|.    ..:...||.|||..||.....|
Mouse   652 P--GKKYPTVLFIYGGPQVQLVNNRFK---GVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGA 711

  Fly   863 IYLKLGTVEISDQINVTQKLSTLFNYIDPDHVGIWGWSYGGYAAAMALANDEAKVFKCAASIAPV 927
            ...|:|.:||.||:...|.|::.:::||.|.|||.|||||||.:.|||. ..:.:|:.|.:.|||
Mouse   712 FKYKMGQIEIDDQVEGLQYLASQYDFIDLDRVGIHGWSYGGYLSLMALM-QRSDIFRVAIAGAPV 775

  Fly   928 TDWAYYDSIYTERYMGLPNTNELGYANSRLSTMAVKLRGK--KYLLVHGTLDDNVHYQQAMILAK 990
            |.|.:||:.|||||||.|:.||.||....::..|.|...:  :.||:||.||:|||:....||..
Mouse   776 TLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLS 840

  Fly   991 NLERQDILFKQISYADEDHGL------SNVRPHLYHSLDRFFGECFASSRLM 1036
            .|.|....:....|..|.|.:      .:...||.|.|....|...|:.:::
Mouse   841 FLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ome	NP_001097606.1	DPPIV_N	367..739	CDD:279298	93/547 (17%)
		Peptidase_S9	828..1033	CDD:278741	80/217 (37%)
		FrsA	<882..1028	CDD:223999	60/153 (39%)
Dpp8	NP_083182.2	DPPIV_N	169..589	CDD:395744	77/441 (17%)
Dpp8	NP_083182.2	Peptidase_S9	680..885	CDD:395257	78/205 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810