DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ome and dpp6b

DIOPT Version :9

Sequence 1:	NP_001097606.1	Gene:	ome / 44297	FlyBaseID:	FBgn0259175	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_001108594.1	Gene:	dpp6b / 566832	ZFINID:	ZDB-GENE-070705-88	Length:	868	Species:	Danio rerio

Alignment Length:	982	Identity:	271/982 - (27%)
Similarity:	443/982 - (45%)	Gaps:	166/982 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 ENLGGKIYITPADIPPPPQPPHQSGSNSHSHHNGSNRQQQQHQQHPHSLHSHIHPHPHPHHQHGH 158
            :...|||. |....|.||:..|..|.......|.|.:.       ||      ||...|
Zfish     6 QRFSGKIN-TNKSFPHPPEASHLLGGQVPEEENKSGKS-------PH------HPSCRP------ 50

  Fly   159 RTPPHRCKCEHPSIELMGYEDSVIATATASNTAANVGVAGGGGVGRHQHPPYYYKAAVGRRSSAK 223
            ..|.||                                 ||||.|.
Zfish    51 PLPRHR---------------------------------GGGGAGS------------------- 63

  Fly   224 LHESMLGGGSSLEDDDGTSAGSFGE---GMSRFKNLMHTKEKKRRVRIILTVVTTVIAVALLATA 285
                  ||..||:......|.:.||   |.:..:|.       :.:.|.|.|:  ::..:|:.|:
Zfish    64 ------GGRGSLQKQARMDADNEGELVGGSAPQRNW-------KGIAIALLVI--LVICSLIVTS 113

  Fly   286 LVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSWSNGNSLIYKENT-SIMEFDAKTG 349
            ::.:     ...:|:...|...:.:||:.||:|.|.....:|.:...|:|.::. ::...:.:|.
Zfish   114 VILL-----TPVEDTSLASKQKVTIEDIFSGKLQAHNPQATWLSDTELLYHDHDGNVKMLNIQTN 173

  Fly   350 ERSILLE----DAQHYVLYEKSADGEFLLLAKNYKKNFRYSFLAEYDLYNLNTKEFIQLTIQNEQ 410
            ....|:|    :......|:.|.|.:::|||.|....::|||:|.|.:.:|::.|.::||....|
Zfish   174 YNKTLVENKTFETYRPTQYQVSPDLKYVLLAYNIMPIYQYSFMAYYIICSLDSPERVELTPNEVQ 238

  Fly   411 H-YLSMVQWSPVGNALVINYDRNLYYKESALAQEIALTSDEQAGIL-NGIPDWVYEEEVFSSNVA 473
            . .|....|.|.|..|:..::.|:|||....:..|.|.|....|:: ||:.||:||||:|.:::|
Zfish   239 STALQYAGWGPKGQQLIFIFENNIYYKAQVNSPSIRLVSTGSLGVIFNGLADWLYEEEIFQNHIA 303

  Fly   474 TWFNPSGTQLAFIKFDDSSTHLINFPYYGDAGDLRYQYPLHQVIAYPKAGSSNPRVELVMVDLKR 538
            .|::|.|.:||:...:|:....:..|.:...     .||..|...|||||..||.:.|.:|.|
Zfish   304 HWWSPDGLRLAYATINDTLVPKMEIPMFTSV-----LYPNGQEYRYPKAGEENPEIYLSVVSL-- 361

  Fly   539 AVAGGDFVTV-MPVPSALNTETDYIVTVVSWVDDDNVLSIWMNRIQNAAYVVTFDGLNRKVIYSA 602
               .|...|| |..|.......||.:|:|.|.....:...|:||.||::           ::...
Zfish   362 ---NGPLHTVRMKKPEDPRIRKDYYITMVKWATSTKLAVNWLNRAQNSS-----------ILTLC 412

  Fly   603 ESKTG------------WVDLYT-APFRNRNGSRLAF--VLP---HNNYKHVQLLSSTVASSEPQ 649
            |:.||            |:.... .|..:::|.|..|  .:|   ...:.|:. :|::..:|...
Zfish   413 EATTGICTKKHEDESDSWLHRQNEPPLFSKDGYRFFFTRAVPQGGRGKFFHIS-MSTSQPNSSTD 476

  Fly   650 ALEPLTEGKYVVDSILHWDGKNDIIFYTANTEDHPEQLHLYAIRALAKQSPKCLTCNLIKSGDVQ 714
            .|:.||.|.:.|..||.::....|::: .:|||...:..||:.......:.:||:|| .:.|
Zfish   477 TLQSLTSGDWDVTQILAYNEDTRIVYF-LSTEDGASRRQLYSANTTGSFNRRCLSCN-FRCG--- 536

  Fly   715 QTYFSATFN-DNNHIVITSLGPGIPTTHIYEWKYENSQVVISKVLDWETNESLRAKLKGVALPSH 778
              |.|.:|: |.|:..:...|||:|.:.:|..:|...:    |:||.||||.|...:....:|..
Zfish   537 --YVSGSFSPDANYFFLNCKGPGVPHSAVYSTRYGQYE----KILDVETNELLNVTVNNTQMPIV 595

  Fly   779 KILTVDIDGGFQAKVLLQLPPNLDTSGATKYPMLVDVYGGPDSYSVTNKWMVDWGTYLSSNQSVI 843
            :...|:||....:..:|:....:.||   .||:|:.|.|.|....||.::.|||.|.|.|:.:.|
Zfish   596 EYRNVNIDDYVLSMQILKPAVFVATS---HYPLLLLVDGTPGGQMVTEQFQVDWSTVLVSSFNTI 657

  Fly   844 YAKIDGRGSGLRGESLLHAIYLKLGTVEISDQINVTQKLSTLFNYIDPDHVGIWGWSYGGYAAAM 908
            ..::||||||.:|.:|||.:..|||..|..|.:...:.:|.: .|||...:|::|.:||||.|:.
Zfish   658 VVRLDGRGSGFQGTNLLHRVKKKLGEFEERDHLEALRIMSQM-TYIDNSRIGVYGKAYGGYLASR 721

  Fly   909 ALANDE----AKV-FKCAASIAPVTDWAYYDSIYTERYMGLPNTNELGYANSRLSTMAVKLRGKK 968
            .|..||    :|: .||..:::|:||::.|.|.::|||:|||..|:..|..:||:....:||.||
Zfish   722 LLHLDESPNLSKIKIKCGTAVSPITDFSIYASAFSERYLGLPQINKREYEMARLTDRMEQLRDKK 786

  Fly   969 YLLVHGTLDDNVHYQQAMILAKNLERQDILFKQISYADEDHGLS--NVRPHLYHSLDRFFGECFA 1031
            .:::|.|.|:.||:|.......:|..:...:....|.||.|.|:  :.:.||..||..||.|||.
Zfish   787 LMIIHPTADEKVHFQHTAKFINHLINEKANYTLQIYPDEGHFLNSKDSQQHLSQSLVNFFVECFT 851

  Fly  1032 SSRLMKS 1038
            ...:::|
Zfish   852 PPEIIQS 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ome	NP_001097606.1	DPPIV_N	367..739	CDD:279298	112/393 (28%)
		Peptidase_S9	828..1033	CDD:278741	79/211 (37%)
		FrsA	<882..1028	CDD:223999	54/152 (36%)
dpp6b	NP_001108594.1	DPPIV_N	195..560	CDD:279298	112/393 (28%)
		DAP2	<433..850	CDD:224423	137/432 (32%)
		Abhydrolase	642..850	CDD:304388	77/208 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.780