DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ome and fap

DIOPT Version :9

Sequence 1:	NP_001097606.1	Gene:	ome / 44297	FlyBaseID:	FBgn0259175	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	XP_001920834.4	Gene:	fap / 565888	ZFINID:	ZDB-GENE-081104-439	Length:	750	Species:	Danio rerio

Alignment Length:	797	Identity:	284/797 - (35%)
Similarity:	429/797 - (53%)	Gaps:	80/797 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 RIILTVVTTVIAVALLATALVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSWSNGN 331
            ::.:.:|..|:.:.|:|......:..|       ||........:|..:..:..|.:|..|.:.|
Zfish     5 KVCVALVGAVVVITLIAIPTAIYVNRD-------DSALKRTYSFDDFYNDTIRYKTYNLRWISDN 62

  Fly   332 SLIYKENTS-IMEFDAKTGERSILLE-------DAQHYVLYEKSADGEFLLLAKNYKKNFRYSFL 388
            ..::|.|.. |...:|:|.|.|:.|.       ||..|:|   |||.:|.....||.|.:|:||.
Zfish    63 EYLHKTNEGHIYLHNAETKESSVYLSNSTFAQVDATDYIL---SADRKFAAFESNYSKQWRHSFT 124

  Fly   389 AEYDLYNLNTKEF---IQLTIQNEQHYLSMVQWSPVGNALVINYDRNLYYKESALAQEIALTSDE 450
            |.|.:||:.:.||   :|:     .|...::.|:||||.|...::.|:|.|.||.|:.:.:|.:.
Zfish   125 ASYSIYNVESGEFLSKVQI-----PHVTQLLTWAPVGNKLAYVWNFNIYLKASATAEAVQVTHNG 184

  Fly   451 QAG-ILNGIPDWVYEEEVFSSNVATWFNPSGTQLAFIKFDDSSTHLINFPYYGDAGDLRYQYPLH 514
            :.. ||||:||||||||||:||.|.|::|.|..||:::.:|:..|.|.:..||:.     |||:.
Zfish   185 KGNEILNGVPDWVYEEEVFASNEAIWWSPQGKYLAYLQVNDTGVHSIEYSLYGND-----QYPVT 244

  Fly   515 QVIAYPKAGSSNPRVELVMVDLKRAVAGGDFVTVMPVPSALNTETDYIVTVVSWVDDDNVLSIWM 579
            ..:.||||||..||..|.::|::......:.|    ||.::.:...|:.| |:||.||.:...||
Zfish   245 VFVPYPKAGSVIPRARLFVIDVENPSRQSEVV----VPKSVGSGDHYLST-VTWVTDDRLAVQWM 304

  Fly   580 NRIQNAA--YVVTFDGLNRK--VIYSAESKTGWVDLY--TAPFRNRNGSRLAFVLPHNN-YKHVQ 637
            .|.|::.  .:..:||...|  ..:..:||||||..|  :||:...|......|:.::| |||:.
Zfish   305 PRRQDSVLLQIYDYDGTKWKESTKFEQKSKTGWVGRYFPSAPYFAANNMSFYKVMSNDNGYKHLH 369

  Fly   638 LLSSTVASSEPQALEPLTEGKYVVDSILHWDGK--NDIIFYTANTEDH---PEQLHLY--AIRAL 695
            .:::..|:       |:|.||:.|..|    .|  .|.|:|.:|  :|   |.|.:||  :|.:.
Zfish   370 YVNAGKAT-------PITSGKWEVIYI----SKVTKDSIYYVSN--EHMARPGQRNLYKISISSS 421

  Fly   696 AKQSPKCLTCNLIKSGDVQQTYFSATFNDN-NHIVITSLGPGIPTTHIYEWKYENSQVVISKVLD 759
            ...:||||||.|.:.   :..|.||.|:.| ::..:...|||:|   ::...........::||
Zfish   422 GHSAPKCLTCALYED---RCQYNSAYFSLNASYFRMDCYGPGLP---LFTMMDNRGPAKETQVL- 479

  Fly   760 WETNESLRAKL-KGVALPSHKILTVDIDGGFQAKVLLQLPPNLDTSGATKYPMLVDVYGGPDSYS 823
             |.|:.|...| ..:.:|:.|..|:.| .||.....:..|||.|:|  .|||:|:||||||.|.:
Zfish   480 -EDNKKLENILTTELLMPTKKRGTLKI-AGFDLWYQMMFPPNFDSS--KKYPLLIDVYGGPASQN 540

  Fly   824 VTNKWMVDWGTYLSSNQSVIYAKIDGRGSGLRGESLLHAIYLKLGTVEISDQINVTQKLSTLFNY 888
            :...:.::|.|||.|.:.:|.|..||||||.:|:.::||||.:|||.|:.|||...:|...: .:
Zfish   541 IDYVFRLEWATYLCSTERIIVASFDGRGSGFQGDEIMHAIYERLGTYEVEDQITAVRKFIEM-GF 604

  Fly   889 IDPDHVGIWGWSYGGYAAAMALANDEAKVFKCAASIAPVTDWAYYDSIYTERYMGLPNTNELGYA 953
            ||.|.:.:||||||||..:|||.:... :|||..::|||..|.|||::||||||..|..|...|.
Zfish   605 IDKDRIAMWGWSYGGYVTSMALGSGSG-LFKCGIAVAPVAKWEYYDAVYTERYMHRPQDNFESYK 668

  Fly   954 NSRLSTMAVKLRGKKYLLVHGTLDDNVHYQQAMILAKNLERQDILFKQISYADEDHGLS-NVRPH 1017
            ||.::..|...:..:|||||||.|||||:|||..::|.|....:.|:.:.|.|:||.|| ..|.|
Zfish   669 NSTVTDRAKNFKSVQYLLVHGTADDNVHFQQAAQISKALVENQVDFEAMWYTDKDHSLSGKARYH 733

  Fly  1018 LYHSLDRFFGECFASSR 1034
            ||..|:.|...|||..:
Zfish   734 LYTHLNHFLKNCFAEKK 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ome	NP_001097606.1	DPPIV_N	367..739	CDD:279298	136/390 (35%)
		Peptidase_S9	828..1033	CDD:278741	95/205 (46%)
		FrsA	<882..1028	CDD:223999	66/146 (45%)
fap	XP_001920834.4	DPPIV_N	103..462	CDD:279298	136/389 (35%)
		FrsA	492..740	CDD:223999	113/252 (45%)
		Peptidase_S9	549..746	CDD:278741	92/198 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	203	1.000	Domainoid score	I2930
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	448	1.000	Inparanoid score	I1602
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm26370
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1793
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.900