DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ome and dpp4

DIOPT Version :9

Sequence 1:	NP_001097606.1	Gene:	ome / 44297	FlyBaseID:	FBgn0259175	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	XP_012825865.2	Gene:	dpp4 / 548987	XenbaseID:	XB-GENE-976654	Length:	810	Species:	Xenopus tropicalis

Alignment Length:	780	Identity:	276/780 - (35%)
Similarity:	421/780 - (53%)	Gaps:	68/780 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 VVTTVIA--VALLATALVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSWSNGNSLI 334
            ||.||:|  ||||||          |..:|    :.....|||....:..||.|...|.:.|..:
Frog    75 VVVTVVAVPVALLAT----------KGKED----TRKTFTLEDYFGDEYRAKSFGLKWVSENEFL 125

  Fly   335 YKENTSIMEFDAKTGERSILLEDAQHY----VLYEKSADGEFLLLAKNYKKNFRYSFLAEYDLYN 395
            ::...:::.::....:.:.::.:...|    ..|..|.:..:.||..||:|.:|:|:.|.|.:|:
Frog   126 FRTKDNVLIYNVDNEKTTEMISNTTIYNSNSSFYTLSDNRNYALLQYNYEKLWRHSYTASYHIYD 190

  Fly   396 LNTKEFIQLTIQNEQHYLSMVQWSPVGNALVINYDRNLYYKESALAQEIALTSD-EQAGILNGIP 459
            ....|.:...:...|  :..:.||||||.|...::.|:|.||:.....|.:|:: |...||||||
Frog   191 TVKGEIVTANVLPNQ--IQYITWSPVGNKLAYVWENNIYIKETPGGSSIQITTNGEHNKILNGIP 253

  Fly   460 DWVYEEEVFSSNVATWFNPSGTQLAFIKFDDSSTHLINFPYYGDAGDLRYQYPLHQVIAYPKAGS 524
            |||||||:||:|.|.|::|....||:::|:|:....|.:.:||:..|   |||...||.|||||:
Frog   254 DWVYEEEMFSTNYALWWSPDAASLAYVEFNDTDVPAIEYSFYGEDSD---QYPKTVVIPYPKAGA 315

  Fly   525 SNPRVELVMVDLKRAVAGGDFVTV-MPVPSALNTETDYIVTVVSWVDDDNVLSIWMNRIQNAAYV 588
            .||.|.|.:|:.....|   |.:| :|.|:.|.| .||.:..::||.:..:...|:.||||.:.:
Frog   316 KNPTVRLFVVNTASLPA---FNSVEIPPPAELRT-IDYYINGMNWVTNGKMAVQWLRRIQNVSLL 376

  Fly   589 VTFD----GLNRKVIYSAESKTGWVDLY--TAPFRNRNGSRLAFVLPH-NNYKHVQLLSSTVASS 646
            ...|    ..|.:.....:|.||||..:  ::|:..::|.:...|:.: ..:||:.|..   .:.
Frog   377 TVCDFAAPAWNCQPPVYEQSTTGWVGYFQPSSPYFTQDGQKYYKVISNKEGFKHIHLFE---GAK 438

  Fly   647 EPQALEPLTEGKYVVDSILHWDGKNDIIFYTANTEDHPEQLHLYAIRA-LAKQSPKCLTCNLIKS 710
            ||.|   :|.||:.|.||.  ...:::::|.:| |..|.:..||.||. ....|.:|:||| |:.
Frog   439 EPVA---ITSGKWEVTSIT--TVASNLLYYISN-EGFPGRRQLYKIRLDGGSNSAQCVTCN-IRQ 496

  Fly   711 GDVQQ--TYFSATFNDNNHIVITSLGPGIPTTHIYEWKYENSQVVISKVLDWETNESLRAKLKGV 773
            ...||  .|||   .|:.:..:...|||:|...:|....:....::      |.||.|:..|..|
Frog   497 ERCQQYSAYFS---KDSKYYALNCNGPGVPIYTLYNSSNDKEMHIM------EDNEELKLLLDEV 552

  Fly   774 ALPSHKILTVDIDGGFQAKVLLQLPPNLDTSGATKYPMLVDVYGGPDSYSVTNKWMVDWGTYLSS 838
            .:|:.:..::.|| ||:....|.||||.|.|  .|||:|:||||||.|..|...:.::|.|||:|
Frog   553 QMPTKENKSIIID-GFELWYQLTLPPNFDKS--KKYPLLIDVYGGPCSQKVDQYFRLNWATYLAS 614

  Fly   839 NQSVIYAKIDGRGSGLRGESLLHAIYLKLGTVEISDQINVTQKLSTLFNYIDPDHVGIWGWSYGG 903
            .:.:|.|..||||||.:|:.::|.:|.||||:|:.|||...:...|| .::||..:.||||||||
Frog   615 TEKIIVASFDGRGSGYQGDKIMHQLYHKLGTLEVQDQIAAARYFITL-GFVDPKRIAIWGWSYGG 678

  Fly   904 YAAAMALANDEAKVFKCAASIAPVTDWAYYDSIYTERYMGL--PNTNELGYANSRLSTMAVKLRG 966
            |..:|.|.:... :|||..::|||:.|.|||||||||||||  |..|...|.:|.:...|.|.:.
Frog   679 YVTSMVLGSGSG-LFKCGIAVAPVSSWEYYDSIYTERYMGLPTPEDNLENYLSSTVMARAQKFKD 742

  Fly   967 KKYLLVHGTLDDNVHYQQAMILAKNLERQDILFKQISYADEDHGL-SNVRPHLYHSLDRFFGECF 1030
            .:|||:|||.|||||:|||..::|.|....:.|..:.|.|:|||: .....|:|..:..:..:||
Frog   743 VEYLLIHGTADDNVHFQQAAHISKALVDAQVDFDTMWYTDKDHGIGGTANRHIYTHMSHYLKQCF 807

Fly 1031 1030
Frog 808 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ome	NP_001097606.1	DPPIV_N	367..739	CDD:279298	130/383 (34%)
		Peptidase_S9	828..1033	CDD:278741	91/206 (44%)
		FrsA	<882..1028	CDD:223999	65/148 (44%)
dpp4	XP_012825865.2	DPPIV_rep	94..114	CDD:408582	6/23 (26%)
		DPPIV_N	162..524	CDD:395744	130/383 (34%)
		Peptidase_S9	604..810	CDD:395257	91/206 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	195	1.000	Domainoid score	I3093
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	444	1.000	Inparanoid score	I1600
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm49522
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.970