DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ome and CG11319

DIOPT Version :9

Sequence 1:	NP_001097606.1	Gene:	ome / 44297	FlyBaseID:	FBgn0259175	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_001285682.1	Gene:	CG11319 / 33923	FlyBaseID:	FBgn0031835	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	930	Identity:	293/930 - (31%)
Similarity:	440/930 - (47%)	Gaps:	181/930 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 LMHTKEKKRRVR-IILTVVTTVIAVALLATALVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLY 319
            |:.:...:|..| |::.::..:|.:||:.|::|.:...||     ........|.|:|::.|...
  Fly    11 LVSSNPNQRNWRGILIALLVIIIVLALIVTSVVLLTPPDE-----GPRVKGQRIKLQDIVDGLFV 70

  Fly   320 AKRFNGSWSNGNSLIYKENTS-IMEFDAKTGERSILLEDAQHYVL----YEKSADGEFLLLAKNY 379
            .:..||||.:|...:|:::.. |...:|......:|:.:.....|    :..|||..:||||:|.
  Fly    71 PQHSNGSWIDGEEFLYQDHLGRICLLNAANRSERVLMSNVTFKTLSPFTFTISADKRYLLLAQNV 135

  Fly   380 KKNFRYSFLAEYDLYNLNTKEFIQL---TIQNEQHYLSMVQWSPVGNALVINYDRNLYYKESALA 441
            .|.||:|:||:|.||::.|.|.|:|   ..|:|..||...:::|.|||||.....::||:|...:
  Fly   136 VKLFRHSYLAQYTLYDIQTSESIKLRHSPHQDEWPYLHYARFTPAGNALVWVQSYDIYYREEVRS 200

  Fly   442 QEI-ALTSDEQAGIL-NGIPDWVYEEEVFSSNVATWFNPSGTQLAFIKFDDSSTHLINFPYYGDA 504
            ..: .:|.|...|:: ||||||:||||:..:|.|.|.:.:|..:.:..|:|:.....:|.:||..
  Fly   201 ASVHRITHDAVPGVVYNGIPDWLYEEEILHANNAIWMSDNGQLMLYATFNDTHVQEQHFAWYGTT 265

  Fly   505 GDL----------------------------RYQYPLHQVIAYPKAGSSNPRVELVMVDLKRAVA 541
            |..                            ...||..:.:.|||.|:.||.|.|.:.|||..:.
  Fly   266 GPSAGGAAAAAAVGAGGAGTGSPGAGGSNPHASLYPEIRSLRYPKPGTQNPTVTLRVADLKDPLK 330

  Fly   542 GGDFVTVMPVPSALNTETDYIVTVVSWVDDDNVLSIWMNRIQNAAYV---------------VTF 591
              ..:|.:..|..:..| |:..:..|||....:..:|:||.||.:.|               |:.
  Fly   331 --VHITDLHPPQIIANE-DHYFSSASWVSHSKIAVVWLNRPQNISVVSVCKAPLFQCIETHRVSG 392

  Fly   592 DGLNRKVIYSAESKTGWVDLYTAPFRNRNGSRLAFVLPHNN-----YKHVQLLSSTVASSEPQAL 651
            ||            .||||....|....|.|....:.|..:     ::|:     .....:...:
  Fly   393 DG------------RGWVDTVAVPLFAANASIYVAISPLRDGLFGYFRHI-----VHVDIDKNRV 440

  Fly   652 EPLTEGKYVVDSILHWDGKNDIIFYTANTEDHPEQLHLYAIRAL------AKQSPKCLTC----- 705
            .|||.|.|.|:.:||||..::.|::....|..|.|.|||.:.||      |.:||.||||
  Fly   441 LPLTHGPYEVNRLLHWDQLDNWIYFLGTPERLPSQQHLYRVSALPARQGQALRSPDCLTCPAVSQ 505

  Fly   706 --------------NLIKSGD-------------------VQQ------------------TYFS 719
                          .|:.:.|                   |:|                  .|..
  Fly   506 WSEGYDEGHTKSPPKLVTAWDDDWEDSEEAEAQPPQPALPVEQQPPGRGQSAPLPPPPSDCLYHE 570

  Fly   720 ATF---NDNNHIVITSLGPGIPTTHIYEWK-----------------------------YENSQV 752
            |.|   ....:::|..|||.:||:.:|..|                             .|....
  Fly   571 AKFPISRQAKYVLIDCLGPVVPTSILYGLKSAAADSAKTKRHSTQQEEPPTEGGDEKPGEEPKSQ 635

  Fly   753 VISKVLDWETNESLRAKLKGVALPSHKILTVDIDGGFQAKVLLQLPPNLDTSGATKYPMLVDVYG 817
            .:..::..:.|..|:.|:...|:|..|...|.|.||:.|:|.|.|||.|.....|:||.::.||.
  Fly   636 FLELLVIVQNNTRLKEKMAKTAMPQIKTFPVMISGGYHAQVRLYLPPVLREDEITRYPTILHVYS 700

  Fly   818 GPDSYSVTNKWMVDWGTYLSSNQSVIYAKIDGRGSGLRGESLLHAIYLKLGTVEISDQINVTQKL 882
            ||.|..||:.|.|||.||||.::..|..:||||||..:|..|||.:|.:||:||:|||:.|::.|
  Fly   701 GPGSQLVTDHWHVDWNTYLSGSKDYIVVEIDGRGSAGQGYQLLHEVYKRLGSVEVSDQLEVSEYL 765

  Fly   883 STLFNYIDPDHVGIWGWSYGGYAAAMALANDEAKVFKCAASIAPVTDWAYYDSIYTERYMGLPNT 947
            ....::||...:|:||||||||.||:|||..:: :|:|..|::|||:|..|||.|.|||:..||.
  Fly   766 RDNLHFIDSRRMGVWGWSYGGYTAALALAGQQS-IFQCGISVSPVTNWKLYDSTYAERYLSFPNV 829

  Fly   948 --NELGYANSRLSTMAVKLRGKKYLLVHGTLDDNVHYQQAMILAKNLERQDILFKQISYADEDHG 1010
              |..||..|.||.....||.:::||||||.|||||.||:|:||::|..:.:|:||..|.||.|.
  Fly   830 TDNYKGYEESDLSKYVDNLRDRQFLLVHGTADDNVHVQQSMVLARSLTSKGVLYKQQIYPDEGHS 894

  Fly  1011 LSNVRPHLYHSLDRFFGECF 1030
            ||.|:.|||.|:..||.:||
  Fly   895 LSGVKRHLYRSMTAFFEDCF 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ome	NP_001097606.1	DPPIV_N	367..739	CDD:279298	132/489 (27%)
		Peptidase_S9	828..1033	CDD:278741	104/205 (51%)
		FrsA	<882..1028	CDD:223999	74/147 (50%)
CG11319	NP_001285682.1	DPPIV_N	123..504	CDD:279298	121/400 (30%)
		DAP2	<641..916	CDD:224423	131/275 (48%)
		Peptidase_S9	711..916	CDD:278741	104/205 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	201	1.000	Domainoid score	I2961
eggNOG	1	0.900	-	-		E1_COG1506
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	303	1.000	Inparanoid score	I594
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		mtm8410
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	P	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
	10	9.870