DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ome and Dpp8

DIOPT Version :9

Sequence 1:	NP_001097606.1	Gene:	ome / 44297	FlyBaseID:	FBgn0259175	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_001381020.1	Gene:	Dpp8 / 315758	RGDID:	1310901	Length:	892	Species:	Rattus norvegicus

Alignment Length:	991	Identity:	214/991 - (21%)
Similarity:	352/991 - (35%)	Gaps:	324/991 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 RVRIILTVVTTVIAVALLATALVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSWSN 329
            |..:...:.|..:.|.:..||          :.::.:..|.:...||     ..|.:|:  |||.
  Rat     7 RCNMAAAMETEQLGVEIFETA----------ECEEGNGESQDRPKLE-----PFYVERY--SWSQ 54

  Fly   330 GNSLIYKENTSIMEFDAKTGERSILLEDAQHYVLYEKSADGEFLLLAKNYKKNFRYSFLAEYDLY 394
            ...|:    |...::      ...::..|.|..::.|.||       .:...:.|..:||.....
  Rat    55 LKKLL----TDTRKY------HGYMMAKAPHDFMFVKRAD-------PDGPHSDRVYYLAMSGEN 102

  Fly   395 NLNTKEFIQLTIQNEQHYLSMVQWSPVGNALVINYDRNLYYKESALAQE------IALTSDE--- 450
            ..||..:.::.....:..:.|:.|.|:.:......|..:|.:|..|.:|      :.:.:.:
  Rat   103 RENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIAAYDYHP 167

  Fly   451 -------QAGILNGI--------------------------------------PDWV-------- 462
                   |||  :||                                      |||:
  Rat   168 GSGTFLFQAG--SGIYHIKDGGPHGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDI 230

  Fly   463 ----------------------YEEEVFSSNVAT-------------WF------NPSGTQLAFI 486
                                  .||:..|:.|||             |:      .|||.::..|
  Rat   231 WISNLVTREERRLTYVHNELASMEEDPRSAGVATFVLQEEFDRYSGYWWCPQAERTPSGGKILRI 295

  Fly   487 KF---DDSSTHLINFPYYGDAGDLRYQYPLHQV-----IAYPKAGSSNPRVELVMVDLKRAVAGG 543
            .:   |:|...:|:           ...|:.:.     ..|||.|::||:|...|.::.....||
  Rat   296 LYEENDESEVEIIH-----------VTSPMLETRRADSFRYPKTGTANPKVTFKMSEIVVDAEGG 349

  Fly   544 -----DFVTVMPVPSALNTETDYIVTVVSWVDDDN-VLSIWMNRIQNAAYVVTF----------D 592
                 |...|.|. ..|....:||.. ..|..:.. ..||.::|.|....:|..          |
  Rat   350 IIDVIDKELVQPF-EILFEGVEYIAR-AGWTPEGKYAWSILLDRSQTHLQIVLISPELFIPVEDD 412

  Fly   593 GLNRK-------------VIYSAESKTGWVDLYTA--PFRNRNGSRLAFVLP---HNNYKHVQLL 639
            .::|:             :||. |:...|::::..  .|...:...:.|:..   ...::|:..:
  Rat   413 AMDRQRLIESVPDSVTPLIIYE-ETTDIWINIHDIFHVFPQTHEDEIEFIFASECKTGFRHLYKI 476

  Fly   640 SSTVASSE----------PQALE-------PLTEGKYVV-----DSILHWDGKNDIIFYTANTED 682
            :|.:..|:          |...:       .:|.|::.|     .:|  |..:...:.|...|:|
  Rat   477 TSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNI--WVDEARKLVYFEGTKD 539

  Fly   683 HPEQLHLYAIRALA--------------------------------KQSPKCLTCNLIKSGD--- 712
            .|.:.||| :.:.|                                ::||.|::...:.|.|
  Rat   540 SPLEHHLY-VTSYANPGDVVRLTDRGYSHSCCLSRHCDFFISKYSNQKSPHCVSLYKLSSPDDDP 603

  Fly   713 VQQT-YFSATFNDNNHIVITSLGPGIPTTHIYEWKYENSQVVISKVLDWETNESLRAKLKGVALP 776
            |.:| .|.||       ::.|.||                                       ||
  Rat   604 VHKTKEFWAT-------ILDSAGP---------------------------------------LP 622

  Fly   777 SH---KILTVDIDGGFQAKVLLQLPPNLDTSGATKYPMLVDVYGGPDSYSVTNKWMVDWGT-YLS 837
            .:   :|.:.:...||....:|..|.:|..  ..|||.::.:||||....|.|::.   |. |..
  Rat   623 DYTPPEIFSFESTTGFTLYGMLYKPHDLQP--GKKYPTVLFIYGGPQVQLVNNRFK---GVKYFR 682

  Fly   838 SNQ----SVIYAKIDGRGSGLRGESLLHAIYLKLGTVEISDQINVTQKLSTLFNYIDPDHVGIWG 898
            .|.    ..:...||.|||..||.....|...|:|.:||.||:...|.|::.:::||.|.|||.|
  Rat   683 LNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASQYDFIDLDRVGIHG 747

  Fly   899 WSYGGYAAAMALANDEAKVFKCAASIAPVTDWAYYDSIYTERYMGLPNTNELGYANSRLSTMAVK 963
            ||||||.:.|||. ..:.:|:.|.:.||||.|.:||:.|||||||.|:.||.||....::..|.|
  Rat   748 WSYGGYLSLMALM-QRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEK 811

  Fly   964 LRGK--KYLLVHGTLDDNVHYQQAMILAKNLERQDILFKQISYADEDHGL------SNVRPHLYH 1020
            ...:  :.||:||.||:|||:....||...|.|....:....|..|.|.:      .:...||.|
  Rat   812 FPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLH 876

  Fly  1021 SLDRFFGECFASSRLM 1036
            .|....|...|:.::|
  Rat   877 YLQENLGSRIAALKVM 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ome	NP_001097606.1	DPPIV_N	367..739	CDD:279298	98/574 (17%)
		Peptidase_S9	828..1033	CDD:278741	80/217 (37%)
		FrsA	<882..1028	CDD:223999	60/153 (39%)
Dpp8	NP_001381020.1	DPPIV_N	169..589	CDD:395744	71/438 (16%)
Dpp8	NP_001381020.1	Peptidase_S9	680..885	CDD:395257	78/205 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810