DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ome and Dpp9

DIOPT Version :9

Sequence 1:	NP_001097606.1	Gene:	ome / 44297	FlyBaseID:	FBgn0259175	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	XP_217309.6	Gene:	Dpp9 / 301130	RGDID:	1588575	Length:	921	Species:	Rattus norvegicus

Alignment Length:	958	Identity:	207/958 - (21%)
Similarity:	357/958 - (37%)	Gaps:	287/958 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 ESMLGGGSSLEDDDGTSAGSFGEGMSRF----------KNLMHTKEKKRRVRIILTVVTTVIAVA 280
            :.|.||.|.:|.   .:||...:..:||          :|::|...|           ::.:.|:
  Rat    58 QRMSGGVSPVEQ---VAAGDMDDTAARFCVQKHSWDGLRNIIHGSRK-----------SSGLIVS 108

  Fly   281 LLATALVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSWSNGNSLIYKENTSIMEFD 345
            .......|:.:.||     |..:|:....|     |..|..|       .|||:|.      |..
  Rat   109 KAPHDFQFVQKPDE-----SGPHSHRLYYL-----GMPYGSR-------ENSLLYS------EIP 150

  Fly   346 AKTGERSILL----------EDAQHYVLYEK----------------------SADGEFLLLAKN 378
            .|..:.::||          :...|:.:|.:                      |..|.||..|.|
  Rat   151 KKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASN 215

  Fly   379 Y--------KKNFR-----------------------------YSFLAEYDLY--NLNTKEFIQL 404
            .        |..|.                             :||:...||:  |:.|.|..:|
  Rat   216 SLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNNDLWVANIETGEERRL 280

  Fly   405 TIQNEQHYLSMVQWSPVGNALVINYDRNLYYKESALAQEIALTSDEQAGILNGIPDWVYEEEVFS 469
            |..::            |:|.|::..::.                       |:..:|.:|| |.
  Rat   281 TFCHQ------------GSASVLDNPKSA-----------------------GVATFVIQEE-FD 309

  Fly   470 SNVATWFNPSGT----------QLAFIKFDDSSTHLINFPYYGDAGDLR----YQYPLHQVIAYP 520
            .....|:.|:.:          ::.:.:.|:|...:|:.|  ..|.:.|    |:        ||
  Rat   310 RFTGCWWCPTASWEGSGGLKTLRILYEEVDESEVEVIHVP--SPALEERKTDSYR--------YP 364

  Fly   521 KAGSSNPRVELVMVDLK-----RAVAGGDFVTVMPVPSALNTETDYIVTVVSWVDDDN-VLSIWM 579
            :.||.||::.|.:.:|:     :.|:..:...|.|. |:|..:.:||.. ..|..|.. ..::::
  Rat   365 RTGSKNPKIALKLAELQTDHQGKIVSSCEKELVQPF-SSLFPKVEYIAR-AGWTRDGRYAWAMFL 427

  Fly   580 NRIQN---------AAYVVTFD--------------GLNRKVIYSAESKTGWVDLYTA--PFRNR 619
            :|.|.         |.::.|.:              .:...:||. |....|::::..  ||...
  Rat   428 DRPQQRLQLVLLPPALFIPTLESEAQWQEAARAIPKNVQPFIIYE-EVTNVWINVHDIFHPFPQA 491

  Fly   620 NGSRLAFVLPHNNYK----HVQLLSSTVASSEPQALEP-----------------LTEGKYVVDS 663
            .|.:....|..|..|    |:..::..:.:::....||                 ||.|::.|.|
  Rat   492 EGQQDFCFLRANECKTGFCHLYRVTVDLKTNDYDWTEPLSPAEDEFKCPIKEEVALTSGEWEVLS 556

  Fly   664 ILH----WDGKNDIIFYTANTEDHPEQLHLYAIRALAKQSPKCLT-------CNLIKSGDVQQTY 717
             .|    |..:...:.|...|:|.|.:.|||.:...:......||       |::.::.|:..::
  Rat   557 -RHGSKIWVNEQTKLVYFQGTKDTPLEHHLYVVSYESAGEIVRLTTPGFSHSCSMSQNFDMFVSH 620

  Fly   718 FSATFNDNNHIVITSLGPGIPTTHIYEWKYENSQVVISKVLDWETNESLRAKLKGVALPS----- 777
            :|:....             |..|:|:....:...:..:...|      .:.::..:.|.
  Rat   621 YSSVSTP-------------PCVHVYKLSGPDDDPLHKQPRFW------ASMMEAASCPPDYVPP 666

  Fly   778 -----HKILTVDIDGGFQAKVLLQLPPNLDTSGATKYPMLVDVYGGPDSYSVTNKWMVDWGTYLS 837
                 |....|.:.|      ::..|..|..  ..|:|.::.|||||....|.|.:.......|:
  Rat   667 EIFHFHTRADVQLYG------MIYKPHTLQP--GRKHPTVLFVYGGPQVQLVNNSFKGIKYLRLN 723

  Fly   838 SNQSVIYA--KIDGRGSGLRGESLLHAIYLKLGTVEISDQINVTQKLSTLFNYIDPDHVGIWGWS 900
            :..|:.||  .||||||..||.....|:..::|.|||.||:...|.::..:.:||...|.|.|||
  Rat   724 TLASLGYAVVVIDGRGSCQRGLHFEGALKNQMGQVEIEDQVEGLQYVAEKYGFIDLSRVAIHGWS 788

  Fly   901 YGGYAAAMALANDEAKVFKCAASIAPVTDWAYYDSIYTERYMGLPNTNELGYANSRLSTMAVKLR 965
            |||:.:.|.|.: :.:|||.|.:.||||.|..||:.||||||.:|..|:.||....::....||.
  Rat   789 YGGFLSLMGLIH-KPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQQGYEAGSVALHVEKLP 852

  Fly   966 GK--KYLLVHGTLDDNVHYQQAMILAKNLERQDILFKQISYADEDHGL 1011
            .:  :.|::||.||:|||:.....|...|.|....::...|.:|.|.:
  Rat   853 NEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSI 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ome	NP_001097606.1	DPPIV_N	367..739	CDD:279298	87/487 (18%)
		Peptidase_S9	828..1033	CDD:278741	69/188 (37%)
		FrsA	<882..1028	CDD:223999	49/132 (37%)
Dpp9	XP_217309.6	DPPIV_N	204..628	CDD:279298	87/486 (18%)
		FrsA	671..921	CDD:223999	83/239 (35%)
		Peptidase_S9	720..921	CDD:278741	69/182 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810