DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ome and SPACUNK4.08

DIOPT Version :9

Sequence 1:	NP_001097606.1	Gene:	ome / 44297	FlyBaseID:	FBgn0259175	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_593970.1	Gene:	SPACUNK4.08 / 2542415	PomBaseID:	SPACUNK4.08	Length:	793	Species:	Schizosaccharomyces pombe

Alignment Length:	846	Identity:	249/846 - (29%)
Similarity:	379/846 - (44%)	Gaps:	125/846 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 SLEDDDGTSAGSFGEGMSRFKNLMHTKEKKRRVRIILTVVTTVIAVALLATALVFILRTDEKDAD 298
            |.||....|...||               .|.||.:      |.|:||:.:.|:..|..    ::
pombe     5 SFEDKGLISRSGFG---------------SRHVRRV------VKALALIFSLLILYLTI----SN 44

  Fly   299 DSDS-NSNNAIDLEDVLSGQLYAKRFNG-SWSNGNSLIYKENTSIMEFDAKTGERSILLEDAQH- 360
            .||| ...:::.|:|::. |.|...:.. :|.:...|   ::|    |..|.|: .|.::|..:
pombe    45 VSDSPPKRDSLSLDDIVL-QKYKPSYKQVNWIDSQGL---KDT----FLVKYGD-LINIQDPYNL 100

  Fly   361 ------------------YVLYEKSADGEFLLLAKNYKKNFRYSFLAEYDLYNLNTKEFIQLTIQ 407
                              |..|..|.|.:::|::.|..:.:|:|..|:|.|||..||:...|...
pombe   101 NKTLFSVSDLVYNGIQLDYDSYSISFDAKYVLVSVNKSQRWRHSSFAQYYLYNTETKDVNMLGQD 165

  Fly   408 NEQHYLSMVQWSPVGNALVINYDRNLYY-KESALAQEIALTSDEQAGILNGIPDWVYEEEVFSSN 471
            ||...:|:.:|||.|:.|...|:.:||. |.....|.  ||.|....:.||:.||:|||||.||.
pombe   166 NEHWTISLAEWSPTGHQLSFVYNNDLYVRKNDGNVQR--LTYDGTVDVFNGLTDWIYEEEVLSSP 228

  Fly   472 VATWFNPSGTQLAFIKFDDSSTHLINFPYYG---DAGDLRYQYPLHQVIAYPKAGSSNPRVELVM 533
            ...|::|...::||:|.::|.....::|.|.   |.....:.|.....|.|||.|:.||.|.|.:
pombe   229 STIWWSPDSDKIAFLKLNESEIPTYHYPLYTAELDPSLPEFDYNKDMAIKYPKPGNPNPSVSLFV 293

  Fly   534 VDLKRAVAGGDFVTVMPVPSALNTETDYIVTVVSWVDDDNVLSIWMNRIQNAAYVVTFDGLNRKV 598
            .|| .:.|..:|......|.|     :.:|..|.||:..:||..:.||..........| ...|.
pombe   294 ADL-NSNASSNFSLWHNEPLA-----EPVVQNVLWVNTSSVLVQFTNRNSTCITARLLD-TELKS 351

  Fly   599 IYSAES---KTGWVDLYTA----PFRN----RNGSRLAF-VLPHNNYKHVQLL----SSTVASSE 647
            |::.::   :.||.::..:    |..|    .|.|...| :|..::|.|:..:    ||.:.
pombe   352 IHTVKTECLEEGWYEVQQSAKMFPLNNSLVWENWSDGYFDILALDDYNHLAFIPFNGSSPIY--- 413

  Fly   648 PQALEPLTEGKY-VVDSILHWDGKNDIIFYTANTEDHPEQLHLYAIRALAKQSPKCLTCNLIKSG 711
                  ||.|.: |.|..:|.||....:::.|..:|..|: |||.:      |...|....|...
pombe   414 ------LTSGAWDVTDGPIHIDGDFGNVYFLATLKDSTER-HLYYV------SLDTLEIYGITDN 465

  Fly   712 DVQQTYFSATFND-NNHIVITSLGPGIPTTHIYEWKYENSQVVISKVLDWETNESLRAKLKGVAL 775
            ...:.|:|.:|:. .:..|:...||.:|      |:...|.......|..|||..|:.:|..:.|
pombe   466 GEDEGYYSTSFSPFGDFYVLNYHGPDVP------WQELRSTKDKDYCLSLETNSRLKQQLSSITL 524

  Fly   776 PS---HKILTVDIDGGFQAKVLLQLPPNLDTSGATKYPMLVDVYGGPDSYSVTNKWMVDWGTYLS 837
            ||   .|:...|....|..:    .|.|.|.:  .|||:|...||||.|..|...:.||:..||:
pombe   525 PSVEYGKLTFNDTTFNFMER----RPRNFDVN--KKYPVLFFAYGGPGSQQVAKLFRVDFQAYLA 583

  Fly   838 SNQ--SVIYAKIDGRGSGLRGESLLHAIYLKLGTVEISDQINVTQKLSTLFNYIDPDHVGIWGWS 900
            |:.  ..|...:||||:|..|.:..:::...||..|..|| ....|......::|.:||||||||
pombe   584 SHPDFEFIVVTLDGRGTGFNGNAFRYSVSRHLGEWESYDQ-GQAGKFWADLPFVDENHVGIWGWS 647

  Fly   901 YGGYAAAMALANDEAKVFKCAASIAPVTDWAYYDSIYTERYMGLPNTNELGYANSRLSTMAVKLR 965
            ||||.....|...:  ||....::||||||..|||:||||||.||..|:.||.||::.......:
pombe   648 YGGYLTLKTLETQD--VFSYGMAVAPVTDWRLYDSVYTERYMDLPQYNKEGYKNSQIHDYEKFKQ 710

  Fly   966 GKKYLLVHGTLDDNVHYQQAMILAKNLERQDIL-FKQISYADEDHGLS--NVRPHLYHSLDRFFG 1027
            .|::.:.|||.|||||:|.:|.|...|...:.. :....:.|..|.:|  |....:||.|..:.|
pombe   711 LKRFFVAHGTGDDNVHFQHSMHLMDGLNLANCYNYDMAVFPDSAHSISYHNASLSIYHRLSEWIG 775

  Fly  1028 E 1028
            :
pombe   776 D 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ome	NP_001097606.1	DPPIV_N	367..739	CDD:279298	112/393 (28%)
		Peptidase_S9	828..1033	CDD:278741	77/206 (37%)
		FrsA	<882..1028	CDD:223999	58/148 (39%)
SPACUNK4.08	NP_593970.1	DPPIV_N	125..494	CDD:279298	113/399 (28%)
SPACUNK4.08	NP_593970.1	Peptidase_S9	574..779	CDD:278741	77/206 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	136	1.000	Domainoid score	I1258
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	303	1.000	Inparanoid score	I594
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm47377
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1793
SonicParanoid	1	1.000	-	-		X274
TreeFam	0	0.000	Not matched by this tool.
	10	9.890