DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ome and SPAC14C4.15c

DIOPT Version :9

Sequence 1:	NP_001097606.1	Gene:	ome / 44297	FlyBaseID:	FBgn0259175	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_594920.2	Gene:	SPAC14C4.15c / 2542105	PomBaseID:	SPAC14C4.15c	Length:	853	Species:	Schizosaccharomyces pombe

Alignment Length:	922	Identity:	223/922 - (24%)
Similarity:	361/922 - (39%)	Gaps:	202/922 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 RSSAKLH-ESMLGGGSSLEDDDGTSAGSFGEGMSRFKN--------LMHTKEKKRRVRIILTVVT 274
            :||.:.| .......||||      ..|:.|..|..:|        :...|.::::.|.|...|.
pombe    14 KSSTRQHWRKRSAVSSSLE------FSSYEESNSPIENTEVLKVSEIEAKKRRRKKHRYIYLAVC 72

  Fly   275 TVIAVALLATALV--FILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSWSNGNSLIYKE 337
            .....::|:.|::  |.|.|:.   ::.....|::...::.::...:.:.....:......|...
pombe    73 LFFLASVLSCAIIFRFYLHTNR---ENFSLFKNDSYKQKEPITVSHFGESIFLPYHQDIEWITST 134

  Fly   338 NTSIMEFDAKTGERSILLEDAQHYVLYEKSADGEFLLLAKNYKKNFRYSFLAEY----------- 391
            ..:::.:|..|...|:...|.:.|.....|....|:|..||..:. |||...||
pombe   135 EGTVLYYDQSTFSLSLFYPDGKEYGSNVDSLITSFVLTCKNLHRK-RYSSDMEYIAFSCSKDRRW 198

  Fly   392 ------DLYNLNTKEFIQLTIQNEQHYLS-------MVQWSPVGNALVINYDRNLYYKESALAQE 443
                  |:|      .::......:|..|       :.:|||:|:.||.....||:..||.....
pombe   199 RHSYYEDVY------LVERATGRIEHLASDQSKKIVVAEWSPIGHKLVYGLGSNLFIWESFSEPP 257

  Fly   444 IALTSDEQA-GILNGIPDWVYEEEVFSSNVATWFNPSGTQLAFIKFDDSSTHLINFPYYGDAGDL 507
            :.:|..... |:.||..|||||||:..|:.|.|::|.|..|:::..|||...:...|:......:
pombe   258 VCITDQSDLDGLFNGNSDWVYEEEILQSSKAVWWSPDGNCLSYLSIDDSKVPVHVLPFEQLDSKV 322

  Fly   508 RYQYPLHQVIAYPKAGSSNPR--VELVMVDLKRAVAGGDFVTV---MPVPSALNTETDYIVTVVS 567
            ..|..::....|     |.|:  :..|.:.:......|:.:.|   .|    |:|:..|| |.|:
pombe   323 EDQNRVNNFFHY-----STPKDPIPFVKLFVNCFTDSGESIEVDSSFP----LSTQHRYI-TDVA 377

  Fly   568 WVDDDNVLSIWMNRIQNAAYVVTFDGLNRKVIYSAESKTGWVDLYTAPFRNRNGSRLAFVLPHNN 632
            |..::.::.:.:.|.........||..:||                ....|...|.....|  .:
pombe   378 WAGNEKLMFVEVLRGNYERVTSLFDLSSRK----------------TTIENTEVSEHPLAL--TS 424

  Fly   633 YKHVQLLSSTVASSEPQALEPLTEGKYVVDSILHWDGKNDIIFYTANTEDHPEQLH--------- 688
            ..|::.||.       ::|..|.| :||....|  ..|..|..|..   |:|..::
pombe   425 SLHLKYLSF-------ESLGNLKE-RYVRQYFL--SNKKRIAIYEL---DNPVPIYLTPVNISFL 476

  Fly   689 --LYAIR------ALAKQSP-----KCLTCNLIKSGDVQQTYFSATF-----NDNNHIVITSLGP 735
              ||.|.      |::..||     :..|.:||.| ::.....|..|     ||.|::::..|||
pombe   477 SDLYLINNTLYFTAISSGSPFSRVYRLCTKSLILS-EINIQIGSGLFGIKVSNDQNYLLVNYLGP 540

  Fly   736 GIPTTHIY---EWKY-------------ENSQVVISKVL-----DWETNESLRAKLKGVALPS-- 777
            .||...||   |.|.             ::|...:.||.     ..||||.|....:..|.||
pombe   541 EIPKQFIYSIHEDKVSTSNDHSKNNLPSDSSSTSLGKVKLELCNSLETNEELIITKEKFAFPSVF 605

  Fly   778 HKILTVDIDGGFQAKVLLQLPPNLDTSGATKYPMLVDVYGGPDSYSVTNKWMVDWGTYLSSNQSV 842
            .|::.|.   ...|.:....|||.:.  ..:||.:..:||.|.|..||.|:.:|....::|..:.
pombe   606 FKVIKVK---NITAYIQEIRPPNFNP--RKRYPTVFHLYGAPQSALVTGKYEMDINELMASVYNF 665

  Fly   843 IYAKIDGRG-SGLRGESLL---HAIYLKLGTVEISDQINVTQKLSTLFNYIDPDHVGIWGWSYGG 903
            :..|:|... |.:.|:.|.   |.:.:|.....:...::..        |||...|||||||:||
pombe   666 LVIKVDIVDISDVSGQHLFSDSHELIIKSWIELLRSYVDTP--------YIDRHRVGIWGWSFGG 722

  Fly   904 YAAAMALANDEAKVFKCAASIAPVTDWAYYDSIYTERYMGLPNTNELGYANSRLST-----MAV- 962
            |.....|.|  |...|..|.:||||||.|||:.|:|..:|         |.|:.:|     .||
pombe   723 YLTLKILEN--ADFIKTGAVVAPVTDWRYYDAYYSENLLG---------AYSKQTTAIYDKTAVH 776

  Fly   963 ------KLRGKKYLLVHGTLDDNVHYQQAMILAKNLERQDIL-FKQISYADEDHGLSN------- 1013
                  ||.|  .|::|||.|||||.:..|.|.|.:..:.:. :......:.:|..|:
pombe   777 YSENFRKLCG--LLVLHGTSDDNVHIENTMQLTKAMVEKGVYNYYPFIVPNANHEFSDPTDYTFL 839

  Fly  1014 ---VRPHLYHSL 1022
               :..|.:|:|
pombe   840 REKLSGHFHHAL 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ome	NP_001097606.1	DPPIV_N	367..739	CDD:279298	101/428 (24%)
		Peptidase_S9	828..1033	CDD:278741	64/222 (29%)
		FrsA	<882..1028	CDD:223999	55/164 (34%)
SPAC14C4.15c	NP_594920.2	DPPIV_N	182..543	CDD:279298	93/408 (23%)
SPAC14C4.15c	NP_594920.2	Abhydrolase	680..846	CDD:304388	56/186 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910