DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ome and Dpp4

DIOPT Version :9

Sequence 1:	NP_001097606.1	Gene:	ome / 44297	FlyBaseID:	FBgn0259175	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_036921.2	Gene:	Dpp4 / 25253	RGDID:	2515	Length:	767	Species:	Rattus norvegicus

Alignment Length:	795	Identity:	262/795 - (32%)
Similarity:	415/795 - (52%)	Gaps:	68/795 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 ILTVVTTVIAVALLATALVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSWSNGNSL 333
            :|..:..|.|:..:.|..|.:|..||..||     |.....|.|.|......|.::..|.:.:..
  Rat     7 VLLGLLGVAALVTIITVPVVLLNKDEAAAD-----SRRTYTLADYLKNTFRVKSYSLRWVSDSEY 66

  Fly   334 IYKENTSIMEFDAKTGERSILLEDAQHYVL------YEKSADGEFLLLAKNYKKNFRYSFLAEYD 392
            :||:..:|:.|:|:.|..||.||::...:.      |..|.|..|:||..||.|.:|:|:.|.|.
  Rat    67 LYKQENNILLFNAEHGNSSIFLENSTFEIFGDSISDYSVSPDRLFVLLEYNYVKQWRHSYTASYS 131

  Fly   393 LYNLNTKEFI-QLTIQNEQHYLSMVQWSPVGNALVINYDRNLYYK-ESALAQEIALTSDEQAGIL 455
            :|:||.::.| :..|.|...:::   ||..|:.|...:..::|.| |..|......::.::..|.
  Rat   132 IYDLNKRQLITEEKIPNNTQWIT---WSQEGHKLAYVWKNDIYVKIEPHLPSHRITSTGKENVIF 193

  Fly   456 NGIPDWVYEEEVFSSNVATWFNPSGTQLAFIKFDDSSTHLINFPYYGDAGDLRYQYPLHQVIAYP 520
            |||.|||||||:|.:..|.|::|:||.||:.:|:|:...||.:.:|.|..   .|||....|.||
  Rat   194 NGINDWVYEEEIFGAYSALWWSPNGTFLAYAQFNDTGVPLIEYSFYSDES---LQYPKTVWIPYP 255

  Fly   521 KAGSSNPRVELVMVDLKRAVAGGDFVTVMPV----PSALNTETDYIVTVVSWVDDDNVLSIWMNR 581
            |||:.||.|:..:|:....   ....|.:|:    |:::.|...|:.. |:||.:|.:...|:.|
  Rat   256 KAGAVNPTVKFFIVNTDSL---SSTTTTIPMQITAPASVTTGDHYLCD-VAWVSEDRISLQWLRR 316

  Fly   582 IQNAAYVVTFDGLNRKVIYSA--------ESKTGWVDLY--TAPFRNRNGSRL-AFVLPHNNYKH 635
            |||.:.:...|.....::::.        .|.||||..:  ..|....:||.. ..|...:.|||
  Rat   317 IQNYSVMAICDYDKTNLVWNCPTTQEHIETSATGWVGRFRPAEPHFTSDGSSFYKIVSDKDGYKH 381

  Fly   636 VQLLSSTVASSEP-QALEPLTEGKYVVDSILHWDGKNDIIFYTANT-EDHPEQLHLYAIRALAKQ 698
            :.....   ..:| |....:|:|.:.|.||...  .:|.::|.:|. ::.|...:||.|:.....
  Rat   382 ICQFQK---DRKPEQDCTFITKGAWEVISIEAL--TSDYLYYISNEYKEMPGGRNLYKIQLTDHT 441

  Fly   699 SPKCLTCNLIKSGDVQQTYFSATFN-DNNHIVITSLGPGIPTTHIYEWKYENSQVVISKVLDWET 762
            :.|||:|:|   ...:..|:|.:.: :..:..:...|||:|   :|.......|..: :||  |.
  Rat   442 NKKCLSCDL---NPERCQYYSVSLSKEAKYYQLGCRGPGLP---LYTLHRSTDQKEL-RVL--ED 497

  Fly   763 NESLRAKLKGVALPSHKILTVDIDGGFQAKVLLQ--LPPNLDTSGATKYPMLVDVYGGPDSYSVT 825
            |.:|...|:.|.:||.|:..:.::   :.:...|  |||:.|.|  .|||:|:|||.||.|....
  Rat   498 NSALDKMLQDVQMPSKKLDFIVLN---ETRFWYQMILPPHFDKS--KKYPLLIDVYAGPCSQKAD 557

  Fly   826 NKWMVDWGTYLSSNQSVIYAKIDGRGSGLRGESLLHAIYLKLGTVEISDQINVTQKLSTLFNYID 890
            ..:.::|.|||:|.:::|.|..||||||.:|:.::|||..:|||:|:.|||...::...: .::|
  Rat   558 AAFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINKRLGTLEVEDQIEAARQFLKM-GFVD 621

  Fly   891 PDHVGIWGWSYGGYAAAMALANDEAKVFKCAASIAPVTDWAYYDSIYTERYMGL--PNTNELGYA 953
            ...|.|||||||||..:|.|.:... ||||..::|||:.|.||||:||||||||  |..|...|.
  Rat   622 SKQVAIWGWSYGGYVTSMVLGSGSG-VFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYR 685

  Fly   954 NSRLSTMAVKLRGKKYLLVHGTLDDNVHYQQAMILAKNLERQDILFKQISYADEDHGL--SNVRP 1016
            ||.:.:.|...:..:|||:|||.|||||:||:..::|.|....:.|:.:.|.|||||:  |....
  Rat   686 NSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDAGVDFQAMWYTDEDHGIASSTAHQ 750

  Fly  1017 HLYHSLDRFFGECFA 1031
            |:|..:..|..:||:
  Rat   751 HIYSHMSHFLQQCFS 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ome	NP_001097606.1	DPPIV_N	367..739	CDD:279298	115/391 (29%)
		Peptidase_S9	828..1033	CDD:278741	91/208 (44%)
		FrsA	<882..1028	CDD:223999	65/149 (44%)
Dpp4	NP_036921.2	DPPIV_rep	36..56	CDD:408582	6/24 (25%)
		DPPIV_N	106..479	CDD:395744	115/390 (29%)
		Peptidase_S9	560..764	CDD:395257	89/205 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335167
Domainoid	1	1.000	194	1.000	Domainoid score	I3074
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm46442
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.750