DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ome and FAP

DIOPT Version :9

Sequence 1:	NP_001097606.1	Gene:	ome / 44297	FlyBaseID:	FBgn0259175	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_004451.2	Gene:	FAP / 2191	HGNCID:	3590	Length:	760	Species:	Homo sapiens

Alignment Length:	824	Identity:	277/824 - (33%)
Similarity:	441/824 - (53%)	Gaps:	119/824 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 KRRVRIILTVVTTVIAVALLATALVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSW 327
            |..|:|:..|.|:.: :|||...:|  ||...  ..:|:.|:..|:.|:|:|:|....|.|..:|
Human     2 KTWVKIVFGVATSAV-LALLVMCIV--LRPSR--VHNSEENTMRALTLKDILNGTFSYKTFFPNW 61

  Fly   328 SNGNSLIYKE-NTSIMEFDAKTGERSILLE-------DAQHYVLYEKSADGEFLLLAKNYKKNFR 384
            .:|...:::. :.:|:.::.:||:...:|.       :|.:|.|   |.|.:|:.|..:|.|.:|
Human    62 ISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGL---SPDRQFVYLESDYSKLWR 123

  Fly   385 YSFLAEYDLYNLNTKEFIQLTIQNEQ----HYLSMVQWSPVGNALVINYDRNLYYKESALAQEIA 445
            ||:.|.|.:|:|:..||::   .||.    .||.   |||||:.|...|..|:|.|:........
Human   124 YSYTATYYIYDLSNGEFVR---GNELPRPIQYLC---WSPVGSKLAYVYQNNIYLKQRPGDPPFQ 182

  Fly   446 LT-SDEQAGILNGIPDWVYEEEVFSSNVATWFNPSGTQLAFIKFDDSSTHLINFPYYGDAGDLRY 509
            :| :..:..|.|||||||||||:.::..|.|::|:|..||:.:|:|:...:|.:.||||.
Human   183 ITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDE----- 242

  Fly   510 QYPLHQVIAYPKAGSSNPRVELVMVDLK-RAVAGGDFVTVMPVPSALNTETDYIVTVVSWVDDDN 573
            |||....|.|||||:.||.|.:.::|.. .|..|...|   ||| |:...:||..:.::||.|:.
Human   243 QYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEV---PVP-AMIASSDYYFSWLTWVTDER 303

  Fly   574 VLSIWMNRIQNAAYVVTFD--------GLNRKVIYSAESKTGWVD--------------LYTAPF 616
            |...|:.|:||.:.:...|        ...:...:..||:|||..              .|...|
Human   304 VCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIF 368

  Fly   617 RNRNGSRLAFVLPHNNYKHVQLLSSTVASSEPQALEPLTEGKYVVDSILHWDGKN------DIIF 675
            .:::|           |||:..:..||.:    |:: :|.||        |:..|      |.:|
Human   369 SDKDG-----------YKHIHYIKDTVEN----AIQ-ITSGK--------WEAINIFRVTQDSLF 409

  Fly   676 YTANT-EDHPEQLHLYAIRALAKQSP--KCLTCNLIKSGDVQQTYFSATFND-NNHIVITSLGPG 736
            |::|. |::|.:.::|.| ::....|  ||:||:|.|.   :..|::|:|:| ..:..:...|||
Human   410 YSSNEFEEYPGRRNIYRI-SIGSYPPSKKCVTCHLRKE---RCQYYTASFSDYAKYYALVCYGPG 470

  Fly   737 IPTTHIYEWKYENSQVVISKVLDWETNESLRAKLKGVALPSHKILTVDIDGGFQAKVLLQ----L 797
            ||.:.:::.:.:..    .|:|  |.|:.|...||.:.||..:|..:::|     ::.|.    |
Human   471 IPISTLHDGRTDQE----IKIL--EENKELENALKNIQLPKEEIKKLEVD-----EITLWYKMIL 524

  Fly   798 PPNLDTSGATKYPMLVDVYGGPDSYSVTNKWMVDWGTYLSSNQSVIYAKIDGRGSGLRGESLLHA 862
            ||..|.|  .|||:|:.|||||.|.||.:.:.|:|.:||:|.:.::.|.:||||:..:|:.||:|
Human   525 PPQFDRS--KKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYA 587

  Fly   863 IYLKLGTVEISDQINVTQKLSTLFNYIDPDHVGIWGWSYGGYAAAMALANDEAKVFKCAASIAPV 927
            :|.|||..|:.|||...:|...: .:||...:.|||||||||.:::|||:... :|||..::|||
Human   588 VYRKLGVYEVEDQITAVRKFIEM-GFIDEKRIAIWGWSYGGYVSSLALASGTG-LFKCGIAVAPV 650

  Fly   928 TDWAYYDSIYTERYMGLP--NTNELGYANSRLSTMAVKLRGKKYLLVHGTLDDNVHYQQAMILAK 990
            :.|.||.|:||||:||||  :.|...|.||.:...|...|...|||:|||.|||||:|.:..:||
Human   651 SSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAK 715

  Fly   991 NLERQDILFKQISYADEDHGLSNVRP-HLYHSLDRFFGECFASS 1033
            .|....:.|:.:.|:|::||||.:.. |||..:..|..:||:.|
Human   716 ALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLS 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ome	NP_001097606.1	DPPIV_N	367..739	CDD:279298	128/409 (31%)
		Peptidase_S9	828..1033	CDD:278741	89/207 (43%)
		FrsA	<882..1028	CDD:223999	64/148 (43%)
FAP	NP_004451.2	DPPIV_N	106..472	CDD:366374	127/408 (31%)
FAP	NP_004451.2	Peptidase_S9	553..756	CDD:366030	87/204 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	192	1.000	Domainoid score	I3219
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H48282
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm42292
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1793
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.750