DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ome and Fap

DIOPT Version :9

Sequence 1:	NP_001097606.1	Gene:	ome / 44297	FlyBaseID:	FBgn0259175	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_620205.1	Gene:	Fap / 192203	RGDID:	621253	Length:	761	Species:	Rattus norvegicus

Alignment Length:	798	Identity:	267/798 - (33%)
Similarity:	432/798 - (54%)	Gaps:	85/798 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 VTTVIAVALLATALVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSWSNGNSLIYK- 336
            |||::|:||:...:|  ||...  ....:.|:..::.|:|:|:|....|.:..:|.:....:::
  Rat    11 VTTLVALALVVICIV--LRPSR--VYSPEGNTGRSLTLKDILNGTFSYKTYFPNWISEQEYLHQS 71

  Fly   337 ENTSIMEFDAKTGERSILLEDAQ----HYVLYEKSADGEFLLLAKNYKKNFRYSFLAEYDLYNLN 397
            |:.:|:.::.:|.|..|:|.::.    :...|..|.|.:|:.|..:|.|.:|||:.|.|.:|:|.
  Rat    72 EDDNIVFYNIETRESYIILSNSTMKSVNATDYGLSPDRQFIYLESDYSKLWRYSYTATYYIYDLQ 136

  Fly   398 TKEFIQ-LTIQNEQHYLSMVQWSPVGNALVINYDRNLYYKESALAQEIALT-SDEQAGILNGIPD 460
            ..||:: ..:.....||.   |||||:.|...|..|:|.|:........:| :..:..|.|||||
  Rat   137 NGEFVRGYELPRPIQYLC---WSPVGSKLAYVYQNNIYLKQRPGDPPFQITYTGRENRIFNGIPD 198

  Fly   461 WVYEEEVFSSNVATWFNPSGTQLAFIKFDDSSTHLINFPYYGDAGDLRYQYPLHQVIAYPKAGSS 525
            ||||||:.::..|.|::|.|..||:::|:||...:|.:.||||.     |||....|.|||||:.
  Rat   199 WVYEEEMLATKYALWWSPDGKYLAYVEFNDSDIPIIAYSYYGDG-----QYPRTINIPYPKAGAK 258

  Fly   526 NPRVELVMVDLKRAVAGGDFVTV---------MPVPSALNTETDYIVTVVSWVDDDNVLSIWMNR 581
            ||.|.:.:||           |:         :|||..: ..:||..|.::||.::.|...|:.|
  Rat   259 NPIVRVFIVD-----------TIYPHHVGPIEVPVPEMI-ASSDYYFTWLTWVTNERVCLQWLKR 311

  Fly   582 IQNAAYVVTFD----------GLNRKVIYSAESKTGWVD---LYTAPFRNRNGSRLAFVLPHNNY 633
            :||.:.:...|          ..|::.|  .||:|||..   :.|..|.....|........:.|
  Rat   312 VQNVSVLSICDFREDWHAWDCPKNQEHI--EESRTGWAGGFFVSTPAFSQDAASYYKIFSDKDGY 374

  Fly   634 KHVQLLSSTVASSEPQALEPLTEGKYVVDSILHWDGKNDIIFYTANT-EDHPEQLHLYAIRALAK 697
            ||:..:..||.:    |:: :|.||:  ::|..:....|.:||::|. |.:|.:.::|.| ::..
  Rat   375 KHIHYIKDTVEN----AIQ-ITSGKW--EAIYIFRVTQDSLFYSSNEFEGYPGRRNIYRI-SIGN 431

  Fly   698 QSP--KCLTCNLIKSGDVQQTYFSATFN-DNNHIVITSLGPGIPTTHIYEWKYENSQVVISKVLD 759
            ..|  ||:||:|.|.   :..|::|:|: ...:..:...|||:|.:.:::.:.:....|:
  Rat   432 SPPSKKCVTCHLRKE---RCQYYTASFSYKAKYYALICYGPGLPISTLHDGRTDQEIQVL----- 488

  Fly   760 WETNESLRAKLKGVALPSHKILTVDIDGGFQAKVLLQLPPNLDTSGATKYPMLVDVYGGPDSYSV 824
             |.|:.|...|:.:.||:.:|..:: |||......:.|||..|.|  .|||:|:.|||||.|.||
  Rat   489 -EENKELENALRNIQLPAVEIKKLE-DGGMTFWYKMILPPQFDRS--KKYPLLIQVYGGPCSQSV 549

  Fly   825 TNKWMVDWGTYLSSNQSVIYAKIDGRGSGLRGESLLHAIYLKLGTVEISDQINVTQKLSTLFNYI 889
            .:.:.|:|.|||:|.:.::.|.:||||:..:|:..|||:|.|||..|:.||:...:|...: .:|
  Rat   550 KSVFSVNWITYLASKEGIVVALVDGRGTAFQGDKFLHAVYRKLGVYEVEDQLTAVRKFIEM-GFI 613

  Fly   890 DPDHVGIWGWSYGGYAAAMALANDEAKVFKCAASIAPVTDWAYYDSIYTERYMGLP--NTNELGY 952
            |...:.|||||||||.:::|||:... :|||..::|||:.|.||.||||||:||||  :.|...|
  Rat   614 DEGRIAIWGWSYGGYVSSLALASGTG-LFKCGIAVAPVSSWEYYASIYTERFMGLPTKDDNLEHY 677

  Fly   953 ANSRLSTMAVKLRGKKYLLVHGTLDDNVHYQQAMILAKNLERQDILFKQISYADEDHGLSNVRP- 1016
            .||.:...|...|...|||:|||.|||||:|.:..:||.|....:.|:.:.|:|::||:|:.|.
  Rat   678 KNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGISSGRSQ 742

  Fly  1017 -HLYHSLDRFFGECFASS 1033
             |||..:..|..:||:.|
  Rat   743 NHLYTHMTHFLKQCFSLS 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ome	NP_001097606.1	DPPIV_N	367..739	CDD:279298	124/399 (31%)
		Peptidase_S9	828..1033	CDD:278741	90/208 (43%)
		FrsA	<882..1028	CDD:223999	65/149 (44%)
Fap	NP_620205.1	DPPIV_N	106..473	CDD:279298	124/399 (31%)
Fap	NP_620205.1	Peptidase_S9	553..760	CDD:278741	90/208 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3074
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H48282
Inparanoid	1	1.050	421	1.000	Inparanoid score	I1733
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm46442
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770