DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ome and DPP6

DIOPT Version :9

Sequence 1:	NP_001097606.1	Gene:	ome / 44297	FlyBaseID:	FBgn0259175	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_570629.2	Gene:	DPP6 / 1804	HGNCID:	3010	Length:	865	Species:	Homo sapiens

Alignment Length:	866	Identity:	229/866 - (26%)
Similarity:	409/866 - (47%)	Gaps:	108/866 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 GGGGVGRHQHPPYYYKAAVGRRSSAKLHESMLGGGSSLEDDDGTSAGSFGEGMSRFKNLMHTKEK 262
            ||||.|....|.:.|:|    ||.....:.::|......:..|
Human    57 GGGGGGAGGRPRFQYQA----RSDGDEEDELVGSNPPQRNWKG---------------------- 95

  Fly   263 KRRVRIILTVVTTVIAVALLATALVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSW 327
                 |.:.::..::..:|:.|:::.:     ..|:|:..:....:.:||:.|...........|
Human    96 -----IAIALLVILVICSLIVTSVILL-----TPAEDNSLSQKKKVTVEDLFSEDFKIHDPEAKW 150

  Fly   328 SNGNSLIYKENT-SIMEFDAKTGERSILLE----DAQHYVLYEKSADGEFLLLAKNYKKNFRYSF 387
            .:....||:|.. ::..::.:|...::|:|    ::...:.||.|.|.|:.|.:.|.:..:::|:
Human   151 ISDTEFIYREQKGTVRLWNVETNTSTVLIEGKKIESLRAIRYEISPDREYALFSYNVEPIYQHSY 215

  Fly   388 LAEY--------DLYNLNTKEFIQLTIQNEQHYLSMVQWSPVGNALVINYDRNLYYKESALAQEI 444
            ...|        |..:|:..|     :.|.:  |....|.|.|..|:..::.|:||......|.|
Human   216 TGYYVLSKIPHGDPQSLDPPE-----VSNAK--LQYAGWGPKGQQLIFIFENNIYYCAHVGKQAI 273

  Fly   445 ALTSDEQAGIL-NGIPDWVYEEEVFSSNVATWFNPSGTQLAFIKFDDSSTHLINFPYYGDAGDLR 508
            .:.|..:.|:: ||:.||:||||:..:::|.|::|.||:||:...:||...::..|.|  .|.:
Human   274 RVVSTGKEGVIYNGLSDWLYEEEILKTHIAHWWSPDGTRLAYAAINDSRVPIMELPTY--TGSI- 335

  Fly   509 YQYPLHQVIAYPKAGSSNPRVELVMVDLKRAVAGGDFVTVMPVPSALNTETDYIVTVVSWVDDDN 573
              ||..:...||||||.||.:.|.::.|......   :.:||.......|  |.:|:|.|.....
Human   336 --YPTVKPYHYPKAGSENPSISLHVIGLNGPTHD---LEMMPPDDPRMRE--YYITMVKWATSTK 393

  Fly   574 VLSIWMNRIQNAAYVVTFDGLNRKVIYSAESKT-GWVDLYT-APFRNRNGSRLAFV--LP---HN 631
            |...|:||.||.:.:...|..........|.:: .|:.... .|..:::|.:..|:  :|   ..
Human   394 VAVTWLNRAQNVSILTLCDATTGVCTKKHEDESEAWLHRQNEEPVFSKDGRKFFFIRAIPQGGRG 458

  Fly   632 NYKHVQLLSSTVASSEPQA----LEPLTEGKYVVDSILHWDGKNDIIFYTANTEDHPEQLHLYAI 692
            .:.|:     ||:||:|.:    ::.:|.|.:.|..||.:|.|.:.|:: .:|||.|.:..||:.
Human   459 KFYHI-----TVSSSQPNSSNDNIQSITSGDWDVTKILAYDEKGNKIYF-LSTEDLPRRRQLYSA 517

  Fly   693 RALAKQSPKCLTCNLIKSGDVQQTYFSATFNDN-NHIVITSLGPGIPTTHIYEWKYENSQVVISK 756
            ..:...:.:||:|:|:::    .|||||:|:.: :..::...|||:|...::....:      .|
Human   518 NTVGNFNRQCLSCDLVEN----CTYFSASFSHSMDFFLLKCEGPGVPMVTVHNTTDK------KK 572

  Fly   757 VLDWETNESLRAKLKGVALPSHKILTVDIDGGFQAKVLLQLPPNLDTSGATKYPMLVDVYGGPDS 821
            :.|.||||.::..:....:|..:...::||.......:|:.....||   |.||:|:.|.|.|.|
Human   573 MFDLETNEHVKKAINDRQMPKVEYRDIEIDDYNLPMQILKPATFTDT---THYPLLLVVDGTPGS 634

  Fly   822 YSVTNKWMVDWGTYLSSNQSVIYAKIDGRGSGLRGESLLHAIYLKLGTVEISDQINVTQKLSTLF 886
            .||..|:.|.|.|.:.|:...:..|.||||||.:|..|||.:..:||.:|..||:   :.:.|:.
Human   635 QSVAEKFEVSWETVMVSSHGAVVVKCDGRGSGFQGTKLLHEVRRRLGLLEEKDQM---EAVRTML 696

  Fly   887 --NYIDPDHVGIWGWSYGGYAAAMAL---ANDEAKVFKCAASIAPVTDWAYYDSIYTERYMGLPN 946
              .|||...|.::|..||||.:...|   ..::.:.|.|.::::|:||:..|.|.::|||:||..
Human   697 KEQYIDRTRVAVFGKDYGGYLSTYILPAKGENQGQTFTCGSALSPITDFKLYASAFSERYLGLHG 761

  Fly   947 TNELGYANSRLSTMAVKLRGKKYLLVHGTLDDNVHYQQAMILAKNLERQDILFKQISYADEDHGL 1011
            .:...|..::::.....|..:::|::|.|.|:.:|:|....|...|.|....:....|.||.|..
Human   762 LDNRAYEMTKVAHRVSALEEQQFLIIHPTADEKIHFQHTAELITQLIRGKANYSLQIYPDESHYF 826

  Fly  1012 --SNVRPHLYHSLDRFFGECF 1030
              |:::.|||.|:..||.|||
Human   827 TSSSLKQHLYRSIINFFVECF 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ome	NP_001097606.1	DPPIV_N	367..739	CDD:279298	108/392 (28%)
		Peptidase_S9	828..1033	CDD:278741	68/210 (32%)
		FrsA	<882..1028	CDD:223999	45/152 (30%)
DPP6	NP_570629.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..88		11/34 (32%)
		DPPIV_N	195..561	CDD:279298	108/392 (28%)
		Abhydrolase	641..850	CDD:304388	68/210 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12225
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm42292
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1793
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.810