Protein Alignment ome and Dpp4

DIOPT Version :10

• Sequence 1: NP_001097606.1
• Gene: ome / 44297
• FlyBaseID: FBgn0259175
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: NP_034204.1
• Gene: Dpp4 / 13482
• MGIID: 94919
• Length: 760
• Species: Mus musculus
• Alignment Length: 795
• Identity: 254/795 - (31%)
• Similarity: 415/795 - (52%)
• Gaps: 75/795 - (9%)

  Fly   269 ILTVVTTVIAVALLATALVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSWSNGNSL 333
            :|..:..|.|:..:.|..:.:|..||..||     |.....|.|.|......|.::..|.:....
Mouse     7 VLLGLLGVAALVTIITVPIVLLSKDEAAAD-----SRRTYSLADYLKSTFRVKSYSLWWVSDFEY 66

  Fly   334 IYKENTSIMEFDAKTGERSILLEDA--QHYVLYEKSADGEFLLLAKNYKKNFRYSFLAEYDLYNL 396
            :||:..:|:..:|:.|..||.||::  :.:..:..|.|..|:||..||.|.:|:|:.|.|::|::
Mouse    67 LYKQENNILLLNAEHGNSSIFLENSTFESFGYHSVSPDRLFVLLEYNYVKQWRHSYTASYNIYDV 131

  Fly   397 NTKEFI-QLTIQNEQHYLSMVQWSPVGNALVINYDRNLYYK-ESALAQEIALTSDEQAGILNGIP 459
            |.::.| :..|.|...:::   |||.|:.|...:..::|.| |..|......::.|:..|.|||.
Mouse   132 NKRQLITEEKIPNNTQWIT---WSPEGHKLAYVWKNDIYVKVEPHLPSHRITSTGEENVIYNGIT 193

  Fly   460 DWVYEEEVFSSNVATWFNPSGTQLAFIKFDDSSTHLINFPYYGDAGDLRYQYPLHQVIAYPKAGS 524
            |||||||||.:..|.|::|:.|.||:.:|:|:...||.:.:|.|..   .|||....|.|||||:
Mouse   194 DWVYEEEVFGAYSALWWSPNNTFLAYAQFNDTGVPLIEYSFYSDES---LQYPKTVWIPYPKAGA 255

  Fly   525 SNPRVELVMVDLKRAVAGGDFVTV-MPVPSALNTETDYIVTVVSWVDDDNVLSIWMNRIQNAAY- 587
            .||.|:..:|::....:......: :|.|:::.....|:..|| |..::.:...|:.||||.:.
Mouse   256 VNPTVKFFIVNIDSLSSSSSAAPIQIPAPASVARGDHYLCDVV-WATEERISLQWLRRIQNYSVM 319

  Fly   588 -VVTFDGLNRKVIYSAE------SKTGWVDLY--TAPFRNRNGSRL-AFVLPHNNYKHV------ 636
             :..:|.:|......:|      |.||||..:  ..|....:||.. ..:...:.|||:
Mouse   320 AICDYDKINLTWNCPSEQQHVEMSTTGWVGRFRPAEPHFTSDGSSFYKIISDKDGYKHICHFPKD 384

  Fly   637 --QLLSSTVASSEPQALEPLTEGKYVVDSILHWDGKNDIIFYTANT-EDHPEQLHLYAIRALAKQ 698
              .....|..:.|..::|.||               :|.::|.:|. ::.|...:||.|:.....
Mouse   385 KKDCTFITKGAWEVISIEALT---------------SDYLYYISNQYKEMPGGRNLYKIQLTDHT 434

  Fly   699 SPKCLTCNLIKSGDVQQTYFSATFN-DNNHIVITSLGPGIPTTHIYEWKYENSQVVISKVLDWET 762
            :.|||:|:|   ...:..|::.:|: :..:..:...|||:|...::. ..::.::   :||  |.
Mouse   435 NVKCLSCDL---NPERCQYYAVSFSKEAKYYQLGCWGPGLPLYTLHR-STDHKEL---RVL--ED 490

  Fly   763 NESLRAKLKGVALPSHKILTVDIDGGFQAKVLLQ--LPPNLDTSGATKYPMLVDVYGGPDSYSVT 825
            |.:|...|:.|.:||.|:..:.::   :.:...|  |||:.|.|  .|||:|:|||.||.|....
Mouse   491 NSALDRMLQDVQMPSKKLDFIVLN---ETRFWYQMILPPHFDKS--KKYPLLLDVYAGPCSQKAD 550

  Fly   826 NKWMVDWGTYLSSNQSVIYAKIDGRGSGLRGESLLHAIYLKLGTVEISDQINVTQKLSTLFNYID 890
            ..:.::|.|||:|.:::|.|..||||||.:|:.::|||..:|||:|:.|||...::...: .::|
Mouse   551 ASFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTLEVEDQIEAARQFVKM-GFVD 614

  Fly   891 PDHVGIWGWSYGGYAAAMALANDEAKVFKCAASIAPVTDWAYYDSIYTERYMGL--PNTNELGYA 953
            ...|.|||||||||..:|.|.:... ||||..::|||:.|.||||:||||||||  |..|...|.
Mouse   615 SKRVAIWGWSYGGYVTSMVLGSGSG-VFKCGIAVAPVSRWEYYDSVYTERYMGLPIPEDNLDHYR 678

  Fly   954 NSRLSTMAVKLRGKKYLLVHGTLDDNVHYQQAMILAKNLERQDILFKQISYADEDHGL--SNVRP 1016
            ||.:.:.|...:..:|||:|||.|||||:||:..::|.|....:.|:.:.|.|||||:  |....
Mouse   679 NSTVMSRAEHFKQVEYLLIHGTADDNVHFQQSAQISKALVDAGVDFQAMWYTDEDHGIASSTAHQ 743

  Fly  1017 HLYHSLDRFFGECFA 1031
            |:|..:..|..:||:
Mouse   744 HIYSHMSHFLQQCFS 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ome	NP_001097606.1	DPPIV_N	367..739	CDD:395744	112/395 (28%)
		Peptidase_S9	828..1033	CDD:459761	91/208 (44%)
Dpp4	NP_034204.1	DPPIV_rep	36..56	CDD:465875	6/24 (25%)
		DPPIV_N	102..472	CDD:395744	112/394 (28%)
		Peptidase_S9	553..757	CDD:459761	89/205 (43%)