DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ome and dpp6a

DIOPT Version :9

Sequence 1:	NP_001097606.1	Gene:	ome / 44297	FlyBaseID:	FBgn0259175	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	XP_009295542.1	Gene:	dpp6a / 100007104	ZFINID:	ZDB-GENE-090918-4	Length:	810	Species:	Danio rerio

Alignment Length:	814	Identity:	242/814 - (29%)
Similarity:	410/814 - (50%)	Gaps:	75/814 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 EGMSRF-KNLMHTKEKKRRVRIILTVVTTVIAVALLATALVFILRTDEKDADDSDSNSNNAIDLE 311
            |...:| |.|:.:...:|..:.|...:..::.:..|....|.:|...|   |||.:..      |
Zfish    22 ESAKKFWKELVGSNPPQRNWKGIAIALLVILVICSLIVTSVILLTPGE---DDSLAFK------E 77

  Fly   312 DVLSGQLYAKRF-----NGSWSNGNSLIYK-ENTSIMEFDAKTGERSILLEDAQHYVL----YEK 366
            .|...:::.|.|     |..|.:.|.|:|: ....::.|:.:|.|.:||:.:.:..:.    ||.
Zfish    78 KVTVEEIFKKDFKVHDPNAKWISNNELLYRTREGDVVRFNMETNESTILVTNRKFEMYKASKYEV 142

  Fly   367 SADGEFLLLAKNYKKNFRYSFLAEYDLYNLNTKEFIQLT---IQNEQHYLSMVQWSPVGNALVIN 428
            |.|.:.:|||.|.:..:.:||.|:|.:.:|.|.|...|.   ::|.  :|....|.|.|..|:..
Zfish   143 SPDMKLVLLAYNVQLVYEHSFTADYIICSLETPETWILNPPEVRNA--HLQYAGWGPRGQQLIFI 205

  Fly   429 YDRNLYYKESALAQEIALTSDEQAGIL-NGIPDWVYEEEVFSSNVATWFNPSGTQLAFIKFDDSS 492
            ::.|:||:.:...:.|.|.|..:.|:: ||:.||:||.|:|.|::|.|::|.|.:||:...:|:.
Zfish   206 FENNIYYRATVENRSIRLVSTGKEGVIFNGLTDWLYEAEIFKSHIAHWWSPDGARLAYATINDTL 270

  Fly   493 THLINFPYYGDAGDLRYQYPLHQVIAYPKAGSSNPRVELVMVDLKRAVAGGDFVTV---MPVPSA 554
            ...:..|.:  .|.|   ||..:...|||||..||.:.|.:|:|     .|...|:   .|....
Zfish   271 VPRMEIPMF--TGSL---YPTARQYHYPKAGEENPVISLYVVNL-----NGPLHTIEMRRPEDQR 325

  Fly   555 LNTETDYIVTVVSWVDDDNVLSIWMNRIQNAAYV---VTFDGLNRKVIYSAESKTGWVDLYT-AP 615
            :.   :|.||:|.|.....:...|:||.||.:.:   |...|:..|. :..||: ||:.... .|
Zfish   326 IG---EYYVTMVKWATSTKLAVNWLNRAQNISILTLCVATTGVCTKK-HEDESE-GWLHRQNEEP 385

  Fly   616 FRNRNGSRLAF--VLP---HNNYKHVQLLSSTVASSEPQALEPLTEGKYVVDSILHWDGKNDIIF 675
            ..:::|.||.|  .:|   ...:.|:. :|.:..:|....|:.:|.|.:.|..:|.:|.::.:|:
Zfish   386 LFSKDGLRLFFTRAIPQGGRGKFFHIS-MSISQPNSSTDTLQSITSGDWDVTQVLAYDEESQLIY 449

  Fly   676 YTANTEDHPEQLHLYAIRALAKQSPKCLTCNLIKSGDVQQTYFSATFNDNNHIVITSLGPGIPTT 740
            : .:|||.|::.|||:...:...:.:||:|:...|.......||.|.   ::.::...|||:|..
Zfish   450 F-LSTEDDPKRRHLYSADTVGTFNRRCLSCDFTDSCGYVSGSFSPTM---DYFLLNCKGPGVPYA 510

  Fly   741 HIYEWKYENSQVVISKVLDWETNESLRAKLKGVALPSHKILTVDIDGGFQAKVLLQLPPNLDTSG 805
            .:|...|.      .||.|.|.|.:||.|:..:.:|..:...::|:....:..:|:....:|||
Zfish   511 AVYSTHYR------QKVQDIELNLNLRRKVNSMQMPRVEYREINIEDYSLSVQILKPAGFIDTS- 568

  Fly   806 ATKYPMLVDVYGGPDSYSVTNKWMVDWGTYLSSNQSVIYAKIDGRGSGLRGESLLHAIYLKLGTV 870
              .||:|:.|.|.|.|.||:.::.:||.:.|.|:..|:..:.||||||.:|.:|||.:..:||..
Zfish   569 --HYPLLLLVDGTPGSQSVSEQFHIDWASVLVSSFGVVAVRFDGRGSGFQGTNLLHKVQRRLGMF 631

  Fly   871 EISDQINVTQKLSTLF--NYIDPDHVGIWGWSYGGYAAAMALANDEAKVFKCAASIAPVTDWAYY 933
            |..||::|   ||.:.  .|||...:|.:|..||||..::.|::::: :.||||.::|:||:|.|
Zfish   632 EEKDQLDV---LSIMMQEQYIDKTRIGAFGQVYGGYITSLLLSSEDS-MLKCAAVLSPITDFALY 692

  Fly   934 DSIYTERYMGLPNTNELGYANSRLSTMAVKLRGKKYLLVHGTLDDNVHYQQAMILAKNLERQDIL 998
            .|.::|||:|.|..:...|..:.|:..|.:...||:|::|.|.|:.||:|........|..:...
Zfish   693 ASAFSERYLGPPKPDRRAYEMANLAYRASQFIDKKFLIIHPTADEKVHFQHTAKFISRLISERAN 757

  Fly   999 FKQISYADEDHGLSN--VRPHLYHSLDRFFGECF 1030
            :....|.||.|.:.|  .|.||..||..||.|||
Zfish   758 YSLQIYPDEGHFIHNELTRQHLSQSLVNFFEECF 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ome	NP_001097606.1	DPPIV_N	367..739	CDD:279298	111/387 (29%)
		Peptidase_S9	828..1033	CDD:278741	76/207 (37%)
		FrsA	<882..1028	CDD:223999	52/149 (35%)
dpp6a	XP_009295542.1	DPPIV_N	143..509	CDD:279298	111/387 (29%)
dpp6a	XP_009295542.1	Abhydrolase	589..791	CDD:304388	74/205 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920