Protein Alignment Idh and IDP1

DIOPT Version :10

• Sequence 1: NP_001137910.2
• Gene: Idh / 44291
• FlyBaseID: FBgn0001248
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_010217.1
• Gene: IDP1 / 851493
• SGDID: S000002224
• Length: 428
• Species: Saccharomyces cerevisiae
• Alignment Length: 433
• Identity: 263/433 - (60%)
• Similarity: 327/433 - (75%)
• Gaps: 17/433 - (3%)

  Fly    41 ISMDNERMSAVSEHSSVVCSPEQMAQKIKA-GPVVDVLGDEMTRIIWDSIKSQLILPFLDIELHT 104
            :||.:.|:.:.|..::.        .|||. .|||::.||||||||||.||.:||||:||::|..
Yeast     1 MSMLSRRLFSTSRLAAF--------SKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKY 57

  Fly   105 YDLGIENRDKTEDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGT 169
            |||.:|:||.|.|::|.|.|||||||.||||||||||||.||:||||.|||||||||||||||||
Yeast    58 YDLSVESRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGT 122

  Fly   170 VFREAIICKNVPRLVTGWQKPIVIGRHAHADQYKAVDYVVPGPGKLTLTWKGTD---GQVIDEVI 231
            ||||.|:...:||||..|:|||:||||||.|||||.|.::||||.|.|.:|.:|   .|.....:
Yeast   123 VFREPIVIPRIPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKV 187

  Fly   232 NDFKGPGIALGMFNTDDSIVDFAHASFKYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLYNKQY 296
            .|:||.|:|:.|:|||:||..|||:|||.|:|:||.|::||||||||||||||||||:::|..||
Yeast   188 YDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQY 252

  Fly   297 KKEYEAAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDG 361
            |.::|..||.|||||||||||..:||:|||:.|.||||||||||.||||:||||||||:|:.|||
Yeast   253 KSKFEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDG 317

  Fly   362 KTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNEPLKQFADTLEQVCID 426
            ||.|:||||||||||:|.||:|:|||||.|||||||:||||.|.:|||...|.:||:.||...::
Yeast   318 KTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLN 382

  Fly   427 TI-ESGAMTKDLAICIKGNINAVTRRDYQETFEFINTLAKNLE 468
            |: :.|.||||||:....|    .|..|..|.||::.:.|.|:
Yeast   383 TVQQDGIMTKDLALACGNN----ERSAYVTTEEFLDAVEKRLQ 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Idh	NP_001137910.2	PTZ00435	63..474	CDD:240417	259/411 (63%)
IDP1	NP_010217.1	PRK08299	18..424	CDD:236226	259/408 (63%)