DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Idh and IDP1

DIOPT Version :9

Sequence 1:	NP_001137910.2	Gene:	Idh / 44291	FlyBaseID:	FBgn0001248	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_010217.1	Gene:	IDP1 / 851493	SGDID:	S000002224	Length:	428	Species:	Saccharomyces cerevisiae

Alignment Length:	433	Identity:	263/433 - (60%)
Similarity:	327/433 - (75%)	Gaps:	17/433 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ISMDNERMSAVSEHSSVVCSPEQMAQKIKA-GPVVDVLGDEMTRIIWDSIKSQLILPFLDIELHT 104
            :||.:.|:.:.|..::.        .|||. .|||::.||||||||||.||.:||||:||::|..
Yeast     1 MSMLSRRLFSTSRLAAF--------SKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKY 57

  Fly   105 YDLGIENRDKTEDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGT 169
            |||.:|:||.|.|::|.|.|||||||.||||||||||||.||:||||.|||||||||||||||||
Yeast    58 YDLSVESRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGT 122

  Fly   170 VFREAIICKNVPRLVTGWQKPIVIGRHAHADQYKAVDYVVPGPGKLTLTWKGTD---GQVIDEVI 231
            ||||.|:...:||||..|:|||:||||||.|||||.|.::||||.|.|.:|.:|   .|.....:
Yeast   123 VFREPIVIPRIPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKV 187

  Fly   232 NDFKGPGIALGMFNTDDSIVDFAHASFKYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLYNKQY 296
            .|:||.|:|:.|:|||:||..|||:|||.|:|:||.|::||||||||||||||||||:::|..||
Yeast   188 YDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQY 252

  Fly   297 KKEYEAAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDG 361
            |.::|..||.|||||||||||..:||:|||:.|.||||||||||.||||:||||||||:|:.|||
Yeast   253 KSKFEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDG 317

  Fly   362 KTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNEPLKQFADTLEQVCID 426
            ||.|:||||||||||:|.||:|:|||||.|||||||:||||.|.:|||...|.:||:.||...::
Yeast   318 KTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLN 382

  Fly   427 TI-ESGAMTKDLAICIKGNINAVTRRDYQETFEFINTLAKNLE 468
            |: :.|.||||||:....|    .|..|..|.||::.:.|.|:
Yeast   383 TVQQDGIMTKDLALACGNN----ERSAYVTTEEFLDAVEKRLQ 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Idh	NP_001137910.2	PTZ00435	63..474	CDD:240417	259/411 (63%)
IDP1	NP_010217.1	PRK08299	18..424	CDD:236226	259/408 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344746
Domainoid	1	1.000	508	1.000	Domainoid score	I48
eggNOG	1	0.900	-	-		E1_COG0538
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21195
Inparanoid	1	1.050	520	1.000	Inparanoid score	I193
Isobase	1	0.950	-	0	Normalized mean entropy	S172
OMA	1	1.010	-	-		QHG62611
OrthoFinder	1	1.000	-	-		FOG0001185
OrthoInspector	1	1.000	-	-		otm46900
orthoMCL	1	0.900	-	-		OOG6_100639
Panther	1	1.100	-	-	LDO	PTHR11822
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5145
SonicParanoid	1	1.000	-	-		X809
TreeFam	1	0.960	-	-
	16	15.740