DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Idh and ICDH

DIOPT Version :9

Sequence 1:	NP_001137910.2	Gene:	Idh / 44291	FlyBaseID:	FBgn0001248	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_175836.1	Gene:	ICDH / 841875	AraportID:	AT1G54340	Length:	416	Species:	Arabidopsis thaliana

Alignment Length:	413	Identity:	269/413 - (65%)
Similarity:	322/413 - (77%)	Gaps:	8/413 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 QKIKA-GPVVDVLGDEMTRIIWDSIKSQLILPFLDIELHTYDLGIENRDKTEDQVTIDCAEAIKK 129
            :|||. .|||::.||||||:||..||.:||.|||::::..:|||:.|||.|:|:|||:.|||..|
plant     4 EKIKVINPVVEMDGDEMTRVIWKFIKDKLIFPFLELDIKYFDLGLPNRDFTDDKVTIETAEATLK 68

  Fly   130 YNVGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVTGWQKPIVIG 194
            |||.||||||||||.||.||.|||||:||||||||||.||||||.|||:|:||||.||.|||.||
plant    69 YNVAIKCATITPDEARVREFGLKKMWRSPNGTIRNILNGTVFREPIICRNIPRLVPGWTKPICIG 133

  Fly   195 RHAHADQYKAVDYVVPGPGKLTLTWK--GTDGQVIDEVINDFKGPGIALGMFNTDDSIVDFAHAS 257
            |||..|||:|.|.:|..||||.|.::  |:..:...||.| |.|.|:||.|:|||:||..||.:|
plant   134 RHAFGDQYRATDLIVNEPGKLKLVFEPSGSSQKTEFEVFN-FTGGGVALAMYNTDESIRAFAESS 197

  Fly   258 FKYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLYNKQYKKEYEAAGIWYEHRLIDDMVAYAMKS 322
            ...|..:|.|||:||||||||.|||||||||:::|...::.:|||||||||||||||||||||||
plant   198 MYTAYQKKWPLYLSTKNTILKIYDGRFKDIFQEVYEANWRSKYEAAGIWYEHRLIDDMVAYAMKS 262

  Fly   323 EGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDGKTVEAEAAHGTVTRHFRFYQQGKETS 387
            |||:||||||||||||||.:||||||||:|||||:||||||:||||||||||||:|.:|:|.|||
plant   263 EGGYVWACKNYDGDVQSDFLAQGYGSLGMMTSVLVCPDGKTIEAEAAHGTVTRHYRVHQKGGETS 327

  Fly   388 TNPIASIFAWTRGLLHRAKLDNNEPLKQFADTLEQVCIDTIESGAMTKDLAICIKGNINAVTRRD 452
            ||.|||||||:|||.||||||:|..|..:.:.||..|:.|:|||.||||||:.|.|   |..|||
plant   328 TNSIASIFAWSRGLAHRAKLDSNAALLSYTEKLEAACMGTVESGKMTKDLALLIHG---AKVRRD 389

  Fly   453 -YQETFEFINTLAKNLEGALAKN 474
             |..|.|||:.:|..|:..|..|
plant   390 QYVNTEEFIDAVAWELKRRLLGN 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Idh	NP_001137910.2	PTZ00435	63..474	CDD:240417	268/411 (65%)
ICDH	NP_175836.1	PLN00103	1..409	CDD:177720	267/408 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	533	1.000	Domainoid score	I60
eggNOG	1	0.900	-	-		E1_COG0538
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	553	1.000	Inparanoid score	I253
OMA	1	1.010	-	-		QHG62611
OrthoDB	1	1.010	-	-		D769322at2759
OrthoFinder	1	1.000	-	-		FOG0001185
OrthoInspector	1	1.000	-	-		otm2951
orthoMCL	1	0.900	-	-		OOG6_100639
Panther	1	1.100	-	-	O	PTHR11822
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X809
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840