DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Idh and idh2

DIOPT Version :9

Sequence 1:	NP_001137910.2	Gene:	Idh / 44291	FlyBaseID:	FBgn0001248	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_955858.1	Gene:	idh2 / 386951	ZFINID:	ZDB-GENE-031118-95	Length:	449	Species:	Danio rerio

Alignment Length:	449	Identity:	275/449 - (61%)
Similarity:	329/449 - (73%)	Gaps:	20/449 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 KISMDNERMSAVSEHSSVVCSPE--------------QMAQKIKAGPVVDVLGDEMTRIIWDSIK 90
            |:.....|.:|....|..|.:|.              |:||     |||::.|||||||||:.||
Zfish     6 KVLSSLSRSAATLSKSPAVLAPACQSLQQRNYADKRIQVAQ-----PVVEMDGDEMTRIIWEFIK 65

  Fly    91 SQLILPFLDIELHTYDLGIENRDKTEDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFNLKKMW 155
            .:|||..::::|..||||:..||:|:||||||.|.|.|||||.:|||||||||.|||||.|||||
Zfish    66 EKLILTNVNVDLKYYDLGLPYRDQTDDQVTIDSAIATKKYNVAVKCATITPDEARVEEFKLKKMW 130

  Fly   156 KSPNGTIRNILGGTVFREAIICKNVPRLVTGWQKPIVIGRHAHADQYKAVDYVVPGPGKLTLTWK 220
            ||||||||||||||||||.|||||:||||.||.:.|.|||||..|||||.|:||..|||..:.:.
Zfish   131 KSPNGTIRNILGGTVFREPIICKNIPRLVPGWTQAITIGRHAFGDQYKATDFVVNQPGKFKMVFT 195

  Fly   221 GTDGQVIDE-VINDFKGPGIALGMFNTDDSIVDFAHASFKYALDRKLPLYMSTKNTILKKYDGRF 284
            ..||....| .:.||.|.|..:||:|||:||..|||:.|:||:.:|.||||||||||||.|||||
Zfish   196 PADGSKNKEWEVYDFPGGGCGMGMYNTDESITGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRF 260

  Fly   285 KDIFEDLYNKQYKKEYEAAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSL 349
            ||||:|::.|.||.|::...|||||||||||||..:||.|.|||||||||||||||.:|||:|||
Zfish   261 KDIFQDIFEKNYKPEFDKLKIWYEHRLIDDMVAQVLKSSGAFVWACKNYDGDVQSDILAQGFGSL 325

  Fly   350 GLMTSVLLCPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNEPLK 414
            |||||||:||||||:||||||||||||:|.:|:|:.||||||||||||||||.||.|||.|..|.
Zfish   326 GLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNPDLI 390

  Fly   415 QFADTLEQVCIDTIESGAMTKDLAICIKGNINAVTRRDYQETFEFINTLAKNLEGALAK 473
            :|:.|||:||::|:|||.||||||.||.|..|......|..|.:|::.:..||:.||.|
Zfish   391 KFSQTLERVCVETVESGVMTKDLAGCIHGLANCKLNEHYVNTTDFLDAIKTNLDKALGK 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Idh	NP_001137910.2	PTZ00435	63..474	CDD:240417	269/412 (65%)
idh2	NP_955858.1	PTZ00435	37..449	CDD:240417	268/416 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248894at33208
OrthoFinder	1	1.000	-	-		FOG0001185
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5145
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850