Protein Alignment Idh and IDH2

DIOPT Version :9

• Sequence 1: NP_001137910.2
• Gene: Idh / 44291
• FlyBaseID: FBgn0001248
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_002159.2
• Gene: IDH2 / 3418
• HGNCID: 5383
• Length: 452
• Species: Homo sapiens
• Alignment Length: 410
• Identity: 267/410 - (65%)
• Similarity: 326/410 - (79%)
• Gaps: 2/410 - (0%)

  Fly    66 QKIK-AGPVVDVLGDEMTRIIWDSIKSQLILPFLDIELHTYDLGIENRDKTEDQVTIDCAEAIKK 129
            ::|| |.|||::.|||||||||..||.:||||.:||:|..:|||:.|||:|:||||||.|.|.:|
Human    42 KRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQK 106

  Fly   130 YNVGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVTGWQKPIVIG 194
            |:|.:|||||||||.|||||.|||||||||||||||||||||||.|||||:||||.||.|||.||
Human   107 YSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIG 171

  Fly   195 RHAHADQYKAVDYVVPGPGKLTLTWKGTDGQVIDE-VINDFKGPGIALGMFNTDDSIVDFAHASF 258
            ||||.|||||.|:|....|...:.:...||..:.| .:.:|...|:.:||:|||:||..|||:.|
Human   172 RHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCF 236

  Fly   259 KYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLYNKQYKKEYEAAGIWYEHRLIDDMVAYAMKSE 323
            :||:.:|.||||||||||||.|||||||||:::::|.||.:::...|||||||||||||..:||.
Human   237 QYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSS 301

  Fly   324 GGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDGKTVEAEAAHGTVTRHFRFYQQGKETST 388
            |||||||||||||||||.:|||:||||||||||:||||||:||||||||||||:|.:|:|:.|||
Human   302 GGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTST 366

  Fly   389 NPIASIFAWTRGLLHRAKLDNNEPLKQFADTLEQVCIDTIESGAMTKDLAICIKGNINAVTRRDY 453
            |||||||||||||.||.|||.|:.|.:||..||:||::|:||||||||||.||.|..|......:
Human   367 NPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHF 431

  Fly   454 QETFEFINTLAKNLEGALAK 473
            ..|.:|::|:..||:.||.:
Human   432 LNTTDFLDTIKSNLDRALGR 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Idh	NP_001137910.2	PTZ00435	63..474	CDD:240417	267/410 (65%)
IDH2	NP_002159.2	PTZ00435	39..451	CDD:240417	267/408 (65%)
		Substrate binding. /evidence=ECO:0000250	134..140		5/5 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62611
OrthoDB	1	1.010	-	-		D248894at33208
OrthoFinder	1	1.000	-	-		FOG0001185
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100639
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5145
SonicParanoid	1	1.000	-	-		X809
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.760