DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Idh and IDH1

DIOPT Version :9

Sequence 1:	NP_001137910.2	Gene:	Idh / 44291	FlyBaseID:	FBgn0001248	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_001269315.1	Gene:	IDH1 / 3417	HGNCID:	5382	Length:	414	Species:	Homo sapiens

Alignment Length:	412	Identity:	297/412 - (72%)
Similarity:	357/412 - (86%)	Gaps:	3/412 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 MAQKIKAGPVVDVLGDEMTRIIWDSIKSQLILPFLDIELHTYDLGIENRDKTEDQVTIDCAEAIK 128
            |::||..|.||::.|||||||||:.||.:||.|:::::||:|||||||||.|.||||.|.|||||
Human     1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIK 65

  Fly   129 KYNVGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVTGWQKPIVI 193
            |:|||:|||||||||||||||.||:||||||||||||||||||||||||||:||||:||.|||:|
Human    66 KHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIII 130

  Fly   194 GRHAHADQYKAVDYVVPGPGKLTLTWKGTDG-QVIDEVINDF-KGPGIALGMFNTDDSIVDFAHA 256
            ||||:.|||:|.|:|||||||:.:|:..:|| |.:..::::| :|.|:|:||:|.|.||.||||:
Human   131 GRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHS 195

  Fly   257 SFKYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLYNKQYKKEYEAAGIWYEHRLIDDMVAYAMK 321
            ||:.||.:..|||:||||||||||||||||||:::|:||||.::||..|||||||||||||.|||
Human   196 SFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMK 260

  Fly   322 SEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDGKTVEAEAAHGTVTRHFRFYQQGKET 386
            |||||:|||||||||||||||||||||||:|||||:|||||||||||||||||||:|.||:|:||
Human   261 SEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQET 325

  Fly   387 STNPIASIFAWTRGLLHRAKLDNNEPLKQFADTLEQVCIDTIESGAMTKDLAICIKGNINAVTRR 451
            |||||||||||||||.||||||||:.|..||:.||:|.|:|||:|.||||||.||||..| |.|.
Human   326 STNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPN-VQRS 389

  Fly   452 DYQETFEFINTLAKNLEGALAK 473
            ||..||||::.|.:||:..||:
Human   390 DYLNTFEFMDKLGENLKIKLAQ 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Idh	NP_001137910.2	PTZ00435	63..474	CDD:240417	297/412 (72%)
IDH1	NP_001269315.1	PTZ00435	1..411	CDD:240417	296/410 (72%)
IDH1	NP_001269315.1	Substrate binding. /evidence=ECO:0000269\|PubMed:15173171, ECO:0007744\|PDB:1T0L	94..100		5/5 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152209
Domainoid	1	1.000	582	1.000	Domainoid score	I210
eggNOG	1	0.900	-	-		E1_COG0538
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21195
Inparanoid	1	1.050	617	1.000	Inparanoid score	I895
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62611
OrthoDB	1	1.010	-	-		D248894at33208
OrthoFinder	1	1.000	-	-		FOG0001185
OrthoInspector	1	1.000	-	-		oto90897
orthoMCL	1	0.900	-	-		OOG6_100639
Panther	1	1.100	-	-	LDO	PTHR11822
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5145
SonicParanoid	1	1.000	-	-		X809
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800