DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Idh and idp1

DIOPT Version :9

Sequence 1:	NP_001137910.2	Gene:	Idh / 44291	FlyBaseID:	FBgn0001248	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_594105.2	Gene:	idp1 / 2542598	PomBaseID:	SPAC6G10.08	Length:	439	Species:	Schizosaccharomyces pombe

Alignment Length:	457	Identity:	259/457 - (56%)
Similarity:	325/457 - (71%)	Gaps:	25/457 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QAVFRANFAISAADPKTHKISMDNERMSAVSEHSSVVCSPEQMAQKIKA-GPVVDVLGDEMTRII 85
            :|..:|.|.::||..     ...|.||::           .:..|||.. .|||::.||||||:|
pombe     5 RAAVKAPFKLAAAGR-----GFMNMRMAS-----------SKSFQKITVKNPVVEMDGDEMTRVI 53

  Fly    86 WDSIKSQLILPFLDIELHTYDLGIENRDKTEDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFN 150
            |..|:.:|:||::||:|..||||||.||||.||:|:|.|:||.|.:||||||||||||.||:|:|
pombe    54 WKIIREKLVLPYMDIKLDYYDLGIEARDKTNDQITVDAAKAILKNDVGIKCATITPDEARVKEYN 118

  Fly   151 LKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVTGWQKPIVIGRHAHADQYKAVDYVVPGPGKL 215
            ||||||||||||||||.||||||.|:.||:|:.:.||..||.|||||..||||:.|.|..|||||
pombe   119 LKKMWKSPNGTIRNILNGTVFREPILIKNIPKYIPGWTNPICIGRHAFGDQYKSTDLVASGPGKL 183

  Fly   216 TLTWKGTDGQVIDEVIN--DFKGPGIALGMFNTDDSIVDFAHASFKYALDRKLPLYMSTKNTILK 278
            .|::.........|..|  :|.|.|:|:.|:||||||..|||:||:.||.:|:|||:||||||||
pombe   184 ELSFTPKGNPSAKETYNVYEFNGSGVAMSMYNTDDSIRGFAHSSFQMALQKKMPLYLSTKNTILK 248

  Fly   279 KYDGRFKDIFEDLYNKQYKKEYEAAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVA 343
            ||||||||.|:::|...||:::|..|:||:|||||||||.|:||.||||||||||||||.||.||
pombe   249 KYDGRFKDTFQEVYESDYKQKFEELGLWYQHRLIDDMVAQAIKSNGGFVWACKNYDGDVMSDVVA 313

  Fly   344 QGYGSLGLMTSVLLCPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLD 408
            |.|||||||||||:.|:|:|.|:|||||||.||:..|.:||:||||.|||||||||||.||.:||
pombe   314 QAYGSLGLMTSVLIHPNGRTFESEAAHGTVQRHYMQYLKGKKTSTNSIASIFAWTRGLAHRGRLD 378

  Fly   409 NNEPLKQFADTLEQVCIDTIESGAMTKDLAICIKGNINAVTRRDYQETFEFINTLAKNLEGALAK 473
            .||.|.:||:.||..|:..:|.|.|||||.:..|      :...|.:||||::.:...|:..|..
pombe   379 GNERLVKFANALEHACVRCVEKGIMTKDLYLLSK------SPNGYVDTFEFLDAVKSELDSELVN 437

  Fly   474 NA 475
            .|
pombe   438 IA 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Idh	NP_001137910.2	PTZ00435	63..474	CDD:240417	250/413 (61%)
idp1	NP_594105.2	PTZ00435	31..435	CDD:240417	249/409 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	500	1.000	Domainoid score	I57
eggNOG	1	0.900	-	-		E1_COG0538
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21195
Inparanoid	1	1.050	511	1.000	Inparanoid score	I232
OMA	1	1.010	-	-		QHG62611
OrthoFinder	1	1.000	-	-		FOG0001185
OrthoInspector	1	1.000	-	-		oto101729
orthoMCL	1	0.900	-	-		OOG6_100639
Panther	1	1.100	-	-	LDO	PTHR11822
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5145
SonicParanoid	1	1.000	-	-		X809
TreeFam	1	0.960	-	-
	14	13.860