Protein Alignment Idh and idh-1

DIOPT Version :9

• Sequence 1: NP_001137910.2
• Gene: Idh / 44291
• FlyBaseID: FBgn0001248
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_001255392.1
• Gene: idh-1 / 177775
• WormBaseID: WBGene00010317
• Length: 435
• Species: Caenorhabditis elegans
• Alignment Length: 405
• Identity: 302/405 - (74%)
• Similarity: 348/405 - (85%)
• Gaps: 3/405 - (0%)

  Fly    65 AQKIKAGPVVDVLGDEMTRIIWDSIKSQLILPFLDIELHTYDLGIENRDKTEDQVTIDCAEAIKK 129
            ||||:.|.:|::.||||||||||.||.:||||::|:.:|.:|||||:||.|:||||||.|.|..|
 Worm    26 AQKIQGGDIVEMQGDEMTRIIWDLIKEKLILPYVDLNVHFFDLGIEHRDATDDQVTIDAANATLK 90

  Fly   130 YNVGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVTGWQKPIVIG 194
            |||.:|||||||||.|||||.|||||||||||||||||||||||.||.|||||||..|.|||:||
 Worm    91 YNVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRLVNTWSKPIIIG 155

  Fly   195 RHAHADQYKAVDYVVPGPGKLTLTWKGTDG-QVIDEVINDFKGPGIALGMFNTDDSIVDFAHASF 258
            ||||||||||.|:||||.|||.:.:...|| |.|.|.:.||||||::|.|:||||||.|||||||
 Worm   156 RHAHADQYKATDFVVPGAGKLEIKFVSADGTQTIQETVFDFKGPGVSLSMYNTDDSIRDFAHASF 220

  Fly   259 KYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLYNKQYKKEYEAAGIWYEHRLIDDMVAYAMKSE 323
            ||||.||.|||:||||||||||||||||||.::| .:|:.|::||||||||||||||||.||||:
 Worm   221 KYALQRKFPLYLSTKNTILKKYDGRFKDIFAEIY-PEYEAEFKAAGIWYEHRLIDDMVAQAMKSD 284

  Fly   324 GGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDGKTVEAEAAHGTVTRHFRFYQQGKETST 388
            |||||||||||||||||||||||||||||||||:|||||||||||||||||||:|.:|:|:||||
 Worm   285 GGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLVCPDGKTVEAEAAHGTVTRHYRMHQKGQETST 349

  Fly   389 NPIASIFAWTRGLLHRAKLDNNEPLKQFADTLEQVCIDTIESGAMTKDLAICIK-GNINAVTRRD 452
            |||||||||:|||.|||.||.|..|:.||:.||.|||:|:|:|.:|||||||:| ||.:||||.|
 Worm   350 NPIASIFAWSRGLAHRATLDKNSALETFANNLEAVCIETMEAGFLTKDLAICVKGGNASAVTRTD 414

  Fly   453 YQETFEFINTLAKNL 467
            |..||||::.||:||
 Worm   415 YLNTFEFLDKLAENL 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Idh	NP_001137910.2	PTZ00435	63..474	CDD:240417	302/405 (75%)
idh-1	NP_001255392.1	PTZ00435	27..432	CDD:240417	301/404 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162405
Domainoid	1	1.000	573	1.000	Domainoid score	I106
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21195
Inparanoid	1	1.050	624	1.000	Inparanoid score	I474
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62611
OrthoDB	1	1.010	-	-		D248894at33208
OrthoFinder	1	1.000	-	-		FOG0001185
OrthoInspector	1	1.000	-	-		oto18068
orthoMCL	1	0.900	-	-		OOG6_100639
Panther	1	1.100	-	-	LDO	PTHR11822
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5145
SonicParanoid	1	1.000	-	-		X809
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940