DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flw and PPP3CC

DIOPT Version :9

Sequence 1:	NP_727418.1	Gene:	flw / 44289	FlyBaseID:	FBgn0000711	Length:	461	Species:	Drosophila melanogaster
Sequence 2:	NP_001230903.1	Gene:	PPP3CC / 5533	HGNCID:	9316	Length:	521	Species:	Homo sapiens

Alignment Length:	267	Identity:	105/267 - (39%)
Similarity:	165/267 - (61%)	Gaps:	19/267 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 IFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLLLA 239
            |..|:..::|::||:.:|||||||:.||::|||.||.|....|||||||||||..|:|.:..|.:
Human    67 ILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWS 131

  Fly   240 YKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNVKLWKTFTDCFNCLPVAAIIDEKIFCCHG 304
            .||.:|:..|||||||||..:...:.|..||:.:|:.:::....:.|:|||:||:::::..|.||
Human   132 LKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHG 196

  Fly   305 GLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPDKD------VQGWGEND-RGVSFTFGVDVV 362
            |:||::..::.||:|.|.|:.|..|.:||||||||.:|      ::.:..|. ||.|:.:....|
Human   197 GMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGNEKTLEHYTHNTVRGCSYFYSYPAV 261

  Fly   363 SKFLNRHELDLICRAHQVVEDGYEFFARRQ------LVTLFSAPNYCGEFDNAGGMMTVDDTLM- 420
            .:||..:.|..|.|||:..:.||..:.:.|      |:|:||||||...::|...::..::.:|
Human   262 CEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMN 326

  Fly   421 -----CS 422
                 ||
Human   327 IRQFNCS 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flw	NP_727418.1	MPP_PP1_PPKL	149..428	CDD:277359	105/267 (39%)
flw	NP_727418.1	PP2Ac	160..430	CDD:197547	105/267 (39%)
PPP3CC	NP_001230903.1	MPP_PP2B	37..341	CDD:277361	105/267 (39%)
		Catalytic. /evidence=ECO:0000305	52..343		105/267 (39%)
		PP2Ac	54..325	CDD:197547	102/257 (40%)
		SAPNY motif. /evidence=ECO:0000250\|UniProtKB:Q08209	303..307		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000250\|UniProtKB:P16298	344..366
		Calmodulin-binding. /evidence=ECO:0000250\|UniProtKB:P16298	395..409
		Autoinhibitory segment. /evidence=ECO:0000250\|UniProtKB:P16298	410..417
		Autoinhibitory domain. /evidence=ECO:0000250\|UniProtKB:P16298	468..490
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	480..521
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820