DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment flw and PPP2CB

DIOPT Version :9

Sequence 1:	NP_727418.1	Gene:	flw / 44289	FlyBaseID:	FBgn0000711	Length:	461	Species:	Drosophila melanogaster
Sequence 2:	NP_001009552.1	Gene:	PPP2CB / 5516	HGNCID:	9300	Length:	309	Species:	Homo sapiens

Alignment Length:	289	Identity:	138/289 - (47%)
Similarity:	191/289 - (66%)	Gaps:	7/289 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 EFVRSCRTGKQVQMTEAEVRGLCLKSREIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGF 211
            |.:..|:     |:.|.:||.||.|::||..::..:.|:..|:.:|||:|||:.||:.||..||.
Human    15 EQLNECK-----QLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGK 74

  Fly   212 PPAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY-N 275
            .|..||||:|||||||..|:||:.||:|.|::|||...:||||||...|.::|||||||.|:| |
Human    75 SPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGN 139

  Fly   276 VKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDPD 340
            ..:||.|||.|:.||:.|::|.:|||.||||||.:..::.||.|.|..:||..|.:|||||||||
Human   140 ANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPD 204

  Fly   341 KDVQGWGENDRGVSFTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGE 405
             |..|||.:.||..:|||.|:...|.:.:.|.|:.||||:|.:||.:...|.:||:|||||||..
Human   205 -DRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYR 268

  Fly   406 FDNAGGMMTVDDTLMCSFQILKPSEKKAK 434
            ..|...:|.:||||..||....|:.::.:
Human   269 CGNQAAIMELDDTLKYSFLQFDPAPRRGE 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flw	NP_727418.1	MPP_PP1_PPKL	149..428	CDD:277359	136/279 (49%)
flw	NP_727418.1	PP2Ac	160..430	CDD:197547	135/270 (50%)
PPP2CB	NP_001009552.1	MPP_PP2A_PP4_PP6	9..293	CDD:277360	138/283 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000018
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820