Protein Alignment flw and PPEF2

DIOPT Version :9

• Sequence 1: NP_727418.1
• Gene: flw / 44289
• FlyBaseID: FBgn0000711
• Length: 461
• Species: Drosophila melanogaster
• Sequence 2: NP_006230.2
• Gene: PPEF2 / 5470
• HGNCID: 9244
• Length: 753
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 129/512 - (25%)
• Similarity: 203/512 - (39%)
• Gaps: 147/512 - (28%)

  Fly    88 SSHDPLDDLTEQQRRLLQQYSISPPSETMISADGDQITVHHPREEPKKSRLKLRDFFVAEFVRSC 152
            |||:..|.||    |:..:...:..||....:|.:.|.|......|:.|...|.|...| .|.:.
Human    76 SSHNDRDFLT----RIFTEDRFAQDSEMKKCSDYESIEVPDSYTGPRLSFPLLPDHATA-LVEAF 135

  Fly   153 RTGKQVQMTEAEVRGLCLKSREIFLQQPILLELEA----PLIICGDIHGQYTDLLRLFEYGGFP- 212
            |. || |:....|..|..::::..:|.|.:..:..    .:.:|||:|||..||:.:|...|.|
Human   136 RL-KQ-QLHARYVLNLLYETKKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLIFIFYKNGLPS 198

  Fly   213 PAANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNV- 276
            |..:|:|.||:|||||.|:|.:.:|.|:.:.||:.|.|.|||||...:|..|||..|...:|.|
Human   199 PERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVH 263

  Fly   277 --KLWKTFTDCFNCLPVAAIIDEKIFCCHGGLS--PDLQGMEQIRR------------------- 318
              ::.:|..|.|..||:|.:||||:...|||:|  .||:.:::|.|
Human   264 GKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITDLELLDKIERSKIVSTMRCKTRQKSEKQM 328

  Fly   319 ----------------------------------------LMRPTDVPDTGLL------------ 331
                                                    ..|.:.:|.:|.|
Human   329 EEKRRANQKSSAQGPIPWFLPESRSLPSSPLRLGSYKAQKTSRSSSIPCSGSLDGRELSRQVRSS 393

  Fly   332 -------C-----------------------------------------DLLWSDPDKDVQGWGE 348
                   |                                         |:|||||... :|...
Human   394 VELELERCRQQAGLLVTGEKEEPSRSASEADSEAGELRKPTQEEWRQVVDILWSDPMAQ-EGCKA 457

  Fly   349 ND-RGVSFTFGVDVVSKFLNRHELDLICRAHQVVEDGYEFFARRQLVTLFSAPNYCGEFDNAGGM 412
            |. ||....||.||..:.|.::.:..:.|:|:...:||||...|:::|:|||.||.....|.|..
Human   458 NTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAY 522

  Fly   413 MTVDDTL---MCSFQILKPS------EKKAKYLYSGMNSSRPTTPQRSAPMLATNKK 460
            :.:...|   :..:|..|.:      ::.::...|.:.:.|......|:.:|:..||
Human   523 VKLGPALTPHIVQYQANKVTHTLTMRQRISRVEESALRALREKLFAHSSDLLSEFKK 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
flw	NP_727418.1	MPP_PP1_PPKL	149..428	CDD:277359	105/411 (26%)
		PP2Ac	160..430	CDD:197547	101/408 (25%)
PPEF2	NP_006230.2	MPP_RdgC	122..537	CDD:277364	107/418 (26%)
		Catalytic	128..540		106/415 (26%)
		PP2Ac	141..540	CDD:197547	100/399 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	318..382		3/63 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..435		0/25 (0%)
		EFh	657..722	CDD:238008
		EF-hand_7	657..721	CDD:290234
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	732..753

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000018
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810