DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment flw and Ppp3ca

DIOPT Version :9

Sequence 1:	NP_727418.1	Gene:	flw / 44289	FlyBaseID:	FBgn0000711	Length:	461	Species:	Drosophila melanogaster
Sequence 2:	NP_032939.1	Gene:	Ppp3ca / 19055	MGIID:	107164	Length:	521	Species:	Mus musculus

Alignment Length:	334	Identity:	120/334 - (35%)
Similarity:	183/334 - (54%)	Gaps:	42/334 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 PPSETMISA---DGDQITVHHPREEPKKSRLKLRDFFVAEFVRSCRTGKQVQMTEAEVRGLCLKS 172
            |||..:.:.   |.|    ..||.:..|:.|.                |:.::.|:....:..:.
Mouse    24 PPSHRLTAKEVFDND----GKPRVDILKAHLM----------------KEGRLEESVALRIITEG 68

  Fly   173 REIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLL 237
            ..|..|:..||:::||:.:|||||||:.||::|||.||.|....|||||||||||..|:|.:..|
Mouse    69 ASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYL 133

  Fly   238 LAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNVKLWKTFTDCFNCLPVAAIIDEKIFCC 302
            .|.||.||:..|||||||||..:...:.|..|||.:|:.:::....|.|:|||:||:::::..|.
Mouse   134 WALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCV 198

  Fly   303 HGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDP------DKDVQGWGEND-RGVSFTFGVD 360
            ||||||::..::.||:|.|..:.|..|.:||:|||||      :|..:.:..|. ||.|:.:...
Mouse   199 HGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYP 263

  Fly   361 VVSKFLNRHELDLICRAHQVVEDGYEFFARRQ------LVTLFSAPNYCGEFDNAGGMMTVDDTL 419
            .|..||..:.|..|.|||:..:.||..:.:.|      |:|:||||||...::|...::..::.:
Mouse   264 AVCDFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNV 328

  Fly   420 M------CS 422
            |      ||
Mouse   329 MNIRQFNCS 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flw	NP_727418.1	MPP_PP1_PPKL	149..428	CDD:277359	111/293 (38%)
flw	NP_727418.1	PP2Ac	160..430	CDD:197547	110/282 (39%)
Ppp3ca	NP_032939.1	MPP_PP2B	41..345	CDD:277361	115/313 (37%)
		Catalytic. /evidence=ECO:0000305	56..340		110/282 (39%)
		SAPNY motif. /evidence=ECO:0000250\|UniProtKB:Q08209	307..311		3/3 (100%)
		Interaction with PxIxIF motif in substrate. /evidence=ECO:0000250\|UniProtKB:Q08209	327..336		1/8 (13%)
		Calcineurin B binding. /evidence=ECO:0000269\|PubMed:26794871	341..369
		Calmodulin-binding. /evidence=ECO:0000269\|PubMed:26794871	392..406
		Autoinhibitory segment. /evidence=ECO:0000269\|PubMed:26794871	407..414
		Autoinhibitory domain. /evidence=ECO:0000269\|PubMed:26794871	465..487
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..521
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820