Protein Alignment arr and DGCR2

DIOPT Version :10

• Sequence 1: NP_524737.2
• Gene: arr / 44279
• FlyBaseID: FBgn0000119
• Length: 1678
• Species: Drosophila melanogaster
• Sequence 2: NP_005128.1
• Gene: DGCR2 / 9993
• HGNCID: 2845
• Length: 550
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 97/564 - (17%)
• Similarity: 136/564 - (24%)
• Gaps: 273/564 - (48%)

  Fly  1319 CGPDHFTCAAPVSGISDVNKDCIPASWRCDGQKDCPDKSDEVGCPTCRAD--------------- 1368
            |.|..|.|.   ||    ...|||..|:|||...|.|:|||..||....:
Human    30 CNPGQFACR---SG----TIQCIPLPWQCDGWATCEDESDEANCPEVTGEVRPHHGKEAVDPRQG 87

  Fly  1369 -------------------QFSCQSGECIDKSLVCDGTTNC-------------------ANG-- 1393
                               :||...|:|.......:||.:|                   .||
Human    88 RARGGDPSHFHAVNVAQPVRFSSFLGKCPTGWHHYEGTASCYRVYLSGENYWDAAQTCQRLNGSL 152

  Fly  1394 ----------------------------------------------------------------- 1393
                                                                             
Human   153 ATFSTDQELRFVLAQEWDQPERSFGWKDQRKLWVGYQYVITGRNRSLEGRWEVAFKGSSEVFLPP 217

  Fly  1394 -----------------------------HD----EADCCKRPGEFQCPINKLCIS--------- 1416
                                         ||    .|:.|.....|.|..::.|:.
Human   218 DPIFASAMSENDNVFCAQLQCFHFPTLRHHDLHSWHAESCYEKSSFLCKRSQTCVDIKDNVVDEG 282

  Fly  1417 ------------------------AALLCDGWENCADGADESSDICLQRRMAP----ATDKRAFM 1453
                                    .|.||:..:.|.....:..:.|....:.|    ..|..|..
Human   283 FYFTPKGDDPCLSCTCHGGEPEMCVAALCERPQGCQQYRKDPKECCKFMCLDPDGNSLFDSMASG 347

  Fly  1454 ILIGATMITIFSIVYLLQFCRTRIGKSRTEPKDDQATDPLSPSTLSKSQRVSKIASVADAVRMST 1518
            :.:..:.|:.|.|:.||.|...|:.:.|.|                      :|.|:..| .:..
Human   348 MRLVVSCISSFLILSLLLFMVHRLRQRRRE----------------------RIESLIGA-NLHH 389

  Fly  1519 LNSRNSMNSYDRNHITGASSSTT------NGSSMVAYPINPPPSPATRSRRPYRHYKI--INQ-- 1573
            .|....:..:|... .|..:..|      :|.....:..:|||        ||..||.  |.|
Human   390 FNLGRRIPGFDYGP-DGFGTGLTPLHLSDDGEGGTFHFHDPPP--------PYTAYKYPDIGQPD 445

  Fly  1574 -PPPPTPCST-------DICDESDSNYTSKSNSNNSNGGATKHSSSSAAACLQYGYDSEPYPPPP 1630
             ||||...|.       |..|:........|.....:||       |..|.|:     ....|.|
Human   446 DPPPPYEASIHPDSVFYDPADDDAFEPVEVSLPAPGDGG-------SEGALLR-----RLEQPLP 498

  Fly  1631 TPRSHYHSDVRIVPESSCPPSPSSRSSTYFSPLPPPPSPVQSPS 1674
            |..:.. :|:....:||             |.|..||.|.||.|
Human   499 TAGASL-ADLEDSADSS-------------SALLVPPDPAQSGS 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
arr	NP_524737.2	LY	162..201	CDD:214531
		NHL	168..503	CDD:302697
		NHL repeat	172..237	CDD:271320
		LY	252..293	CDD:214531
		NHL repeat	261..298	CDD:271320
		NHL repeat	303..339	CDD:271320
		NHL repeat	341..419	CDD:271320
		NHL repeat	428..476	CDD:271320
		LY	472..511	CDD:214531
		NHL repeat	477..503	CDD:271320
		Ldl_recept_b	534..574	CDD:459654
		LY	558..599	CDD:214531
		LY	600..641	CDD:214531
		FXa_inhibition	668..703	CDD:464251
		YncE	<736..886	CDD:442618
		LY	776..818	CDD:214531
		LY	905..946	CDD:214531
		FXa_inhibition	973..1010	CDD:464251
		YncE	<1047..1191	CDD:442618
		LDLa	1319..1362	CDD:238060	18/42 (43%)
		LDLa	1365..1399	CDD:238060	12/186 (6%)
		LDLa	1399..1433	CDD:197566	8/66 (12%)
DGCR2	NP_005128.1	LDLa	30..66	CDD:238060	18/42 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	69..92		0/22 (0%)
		CLECT_DGCR2_like	115..267	CDD:153069	12/151 (8%)
		VWC	271..329	CDD:214564	5/57 (9%)
		PHA03247	<428..537	CDD:223021	36/135 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..550		11/43 (26%)