DRSC/TRiP Functional Genomics Resources

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Protein Alignment arr and Lrp1b

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:XP_006498522.1 Gene:Lrp1b / 94217 MGIID:2151136 Length:4668 Species:Mus musculus


Alignment Length:1528 Identity:452/1528 - (29%)
Similarity:722/1528 - (47%) Gaps:207/1528 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 ATLLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECAQTNSS 151
            |.::|:.||:|:..::.:    ....::|..|...:|:||::.::|:.|||...:.|...:.:.|
Mouse  1291 AFIIFSIRHEIRRIDLHK----GDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSES 1351

  Fly   152 ALQPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPR 216
            .....:    :.|:..||..||||.:||....|||.|...::|||:.|||..:..|....::.||
Mouse  1352 GGVSAI----EVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVSKLDGSLRATLIAGAMEHPR 1412

  Fly   217 AVAVVPARKLLIWTDW-GEYPKIERASMDGDPLSRMTLVKEHV--FWPNGLAVDLKNELIYWTDG 278
            |:|:.|...:|.|||| ..:|:||.|||.|  ..|.|:.|:..  .|||||.||.....|.|||.
Mouse  1413 AIALDPRYGILFWTDWDANFPRIESASMSG--AGRKTIYKDMKTGAWPNGLTVDHFERRIVWTDA 1475

  Fly   279 KHHFIDVMRLDGSSRRTIVNN---LKYPFSLTFYDDRLYWTDWQRGSLNALDLQTRELKELID-T 339
            :...|.....||::...|:..   |.:||:::.|...:|||||:..:|...:..|.:...:|. |
Mouse  1476 RSDAIYSAFYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLAKANKWTGQNVSVIQKT 1540

  Fly   340 PKAPNSVRAWDPSLQPYEDNPCAHNNGN--CSHLCLLATNSQGFSCACPTGVKLISANTCANGSQ 402
            ...|..::.:.||.||...||||.|.|.  ||||||: .:::..:||||..:||.|........:
Mouse  1541 SAQPFDLQIYHPSRQPQAPNPCAANEGRGPCSHLCLI-NHNRSAACACPHLMKLSSDKKTCYEMK 1604

  Fly   403 EMMFIVQRTQISKISLDSPDY----TIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHA 463
            :.:...:|::|..:.:|:| |    |.|.:|  .:.....||:|..||.:||:|::|.||.||..
Mouse  1605 KFLLYARRSEIRGVDIDNP-YVNFITAFTVP--DIDDVAVIDFDASEERLYWTDIKTQTITRAFI 1666

  Fly   464 DGTGVTDFVTSEVRHPDGLALDWLARNLYWTDTVTD--RIEVCRLDGTARKVLIYEHLEEPRAIA 526
            :|||:...::.:::...|||:||::|||||..:..|  :|.|.||||:.:..:|: .:::|:.:|
Mouse  1667 NGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIH-GIDKPQCLA 1730

  Fly   527 VAPSLGWMFWSDWNERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEV 591
            ..|..|.::|:|.|    .:..|::|||...:|. :|...|.|:::|.....:||.......|..
Mouse  1731 AHPVRGKLYWTDGN----TINMANMDGSNSKILF-QNQKEPVGLSIDYVENKLYWISSGNGTINR 1790

  Fly   592 ANMDGSGRRVV--ISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGL 654
            .|:||....|:  :.:.|.....|:|:|..|:|.|.....:...:|..|.|..::.::...::.:
Mouse  1791 CNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCNKRDGRNPSILRNKTSGVVHM 1855

  Fly   655 KVTRLREVRGQNACAVRNGGCSHLCL-NRPRDYVCRCAIDYELANDKRTCVVPAAFLLFSRQEHI 718
            ||......:|.|:|.|.|||||.||| .......|.|.:.|.|..::.:|....:||::|..|.|
Mouse  1856 KVYDKEAQQGSNSCQVNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIESFLMYSVHEGI 1920

  Fly   719 GRISIEYNEGNHNDERIPFKDVRDAHALDVSVAERRIYWTDQKSKCIFRAFLNGSYVQRIVDSGL 783
            ..|.:|..:  ..|..:|......|..:|.......|||||.....|.||..:.::.:.:|.:||
Mouse  1921 RGIPLEPRD--KVDALMPISGAAFAVGIDFHAENDTIYWTDMGLNKISRAKRDQTWKEDVVTNGL 1983

  Fly   784 IGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTE-SP 847
            ...:||||||:|.||||:|.....||||||:||.|.|::.:|:::|||:.:.|.:|:::||| ..
Mouse  1984 GRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGFLFWTEWGQ 2048

  Fly   848 TDSIRRAAMDGSDLQTIVA-GANHAAGLTFDQETRRLYWATQSRPAKIESADWD-GKKRQILV-G 909
            ...|.:|.:|||:...||: |.....|::.|.|..:|||. .:|..|||..|.| |..|::|: |
Mouse  2049 VPCIGKARLDGSEKVMIVSVGITWPNGISIDYEENKLYWC-DARSDKIERIDLDTGANREVLLSG 2112

  Fly   910 SDMDEPYAVSLYQDYVYWSD--WNTGDIERVHKTTGQNRSLVHSGM-TYITSLLVFNDKRQTGVN 971
            |::| .::|:::..|:||||  ...|.:.|.||........:.:|: ..:..:.:||..|:.|.|
Mouse  2113 SNVD-LFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETVTMRTGLGVNLKEIKIFNRVREKGTN 2176

  Fly   972 PCKVNNGGCSHLCLAQPGRRGMTCACPTHYQLAKDGVSCIPPRNYIIFSQRNCFGRLLPNTTDCP 1036
            .|...||||..|||.: |....|||| .|..||.|||:|:....|:::|.|.....:  :.:|..
Mouse  2177 VCAKENGGCQQLCLYR-GNSRRTCAC-AHGYLAGDGVTCLRHEGYLLYSGRTILKSI--HLSDET 2237

  Fly  1037 NIPLPVSG-------KNIRAVDYD-----PITHHIYWIEGRSHSIKRSLAN-GTKVSLLANSGQP 1088
            |:..||..       |||.|:.:|     ..|:.|::.:....:|:....| ..:..::.|.|..
Mouse  2238 NLNSPVRPYENPNYFKNIIALAFDYNQRREGTNRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSV 2302

  Fly  1089 FDLAIDIIGRLLFWTCSQSNSINVTSFLGESVGVID------TGDSEKPRNIAVHAMKRLLFWTD 1147
            ..||.......|:||.|.::||...:......|.||      ..:.:.|..:|:...:.|:|||:
Mouse  2303 EGLAYHRAWDTLYWTSSSTSSITRHTVDQTRPGAIDREAVITMSEDDHPHVLALDECQNLMFWTN 2367

  Fly  1148 VG-SHQAIIRARVDG-NERVELAYKLEGVTALALDQQSDMIYYAHGK--RIDAIDINGKNKKTLV 1208
            .. .|.:|:||.:.| |..|.::..:.....|.:|.:::.:|::.|.  :|:..:.:|..:..:|
Mouse  2368 WNEQHPSIMRATLTGKNAHVVVSTDILTPNGLTIDHRAEKLYFSDGSLGKIERCEYDGSQRHVIV 2432

  Fly  1209 SMHISQVINIAALGGFVYWLD----------DKTGVER--------------ITVNGERRSAELQ 1249
            .......:::|....:::|.|          ..||.|.              |.|..:..|.||.
Mouse  2433 KSGPGTFLSLAVYDSYIFWSDWGRRAILRSNKYTGGETKILRSDIPHQPMGIIAVANDTNSCELS 2497

  Fly  1250 RLPQIT----DIRAVWTPDPKV----------LRNHTCMHSRTKCSHI---------C---IASG 1288
            ....:.    |: .:.|||.:|          |.|:.|:...:.|:..         |   :.:.
Mouse  2498 PCALLNGGCHDL-CLLTPDGRVNCSCRGDRVLLANNRCVTKNSSCNIYSEFECGNGDCVDYVLTC 2561

  Fly  1289 EGIARTRD-------VCS---------------CPKHLMLLEDKENCG--------AFPACGPDH 1323
            :||...:|       .|.               |..|..|.:...:||        ....|....
Mouse  2562 DGIPHCKDKSDEKLLYCENRSCRSGFKPCYNRRCVPHGKLCDGTNDCGDSSDELDCKVSTCSTVE 2626

  Fly  1324 FTCA----APVSGISDVNKDCIPA------------------------------------SWRCD 1348
            |.||    .|.|...:.|.||..|                                    ||.||
Mouse  2627 FRCADGTCIPRSARCNQNMDCSDASDEKGCNNTDCTHFYKLGVKSTGFIRCNSTSLCVLPSWICD 2691

  Fly  1349 GQKDCPDKSDEVGCPT-----CRADQFSCQSGECIDKSLVCDGTTNCANGHDEADC---CKRPGE 1405
            |..||.|.|||:.||.     |..:.|.|.||.||..:.||||..:|.:|.||..|   |.. .:
Mouse  2692 GSNDCGDYSDELKCPVQNKHKCEENYFGCPSGRCILNTWVCDGQKDCEDGLDELHCDSSCSW-NQ 2755

  Fly  1406 FQCPINKLCISAALLCDGWENCADGADESSDIC 1438
            |.|.:.| |||...:|||.::|.|..|||..||
Mouse  2756 FACSVKK-CISKHWICDGEDDCGDSLDESDSIC 2787

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 17/38 (45%)
NHL 168..503 CDD:302697 127/349 (36%)
NHL repeat 172..237 CDD:271320 27/65 (42%)
LY 252..293 CDD:214531 16/42 (38%)
NHL repeat 261..298 CDD:271320 14/36 (39%)
NHL repeat 303..339 CDD:271320 11/36 (31%)
NHL repeat 341..419 CDD:271320 26/79 (33%)
NHL repeat 428..476 CDD:271320 17/47 (36%)
LY 472..511 CDD:214531 17/40 (43%)
NHL repeat 477..503 CDD:271320 12/27 (44%)
Ldl_recept_b 534..573 CDD:278487 11/38 (29%)
LY 558..599 CDD:214531 11/40 (28%)
LY 600..641 CDD:214531 10/42 (24%)
FXa_inhibition 668..703 CDD:291342 14/35 (40%)
LY 739..773 CDD:214531 10/33 (30%)
LY 776..818 CDD:214531 23/41 (56%)
LY 819..860 CDD:214531 14/41 (34%)
FXa_inhibition 973..1010 CDD:291342 19/36 (53%)
LY 1122..1164 CDD:214531 14/49 (29%)
FXa_inhibition 1273..1313 CDD:291342 10/73 (14%)
LDLa 1319..1362 CDD:238060 21/82 (26%)
LDLa 1365..1399 CDD:238060 15/33 (45%)
LDLa 1399..1433 CDD:197566 13/36 (36%)
Lrp1bXP_006498522.1 LDLa 1167..1202 CDD:238060
FXa_inhibition 1207..1243 CDD:373209
LY 1311..1352 CDD:214531 10/40 (25%)
LY 1358..1398 CDD:214531 18/39 (46%)
LY 1402..1445 CDD:214531 18/44 (41%)
LY <1457..1489 CDD:214531 14/31 (45%)
LY 1635..1670 CDD:214531 14/34 (41%)
LY 1672..1714 CDD:214531 16/41 (39%)
LY 1716..1755 CDD:214531 11/43 (26%)
LY <1766..1797 CDD:214531 9/30 (30%)
FXa_inhibition 1869..1905 CDD:373209 14/35 (40%)
NHL 1944..2169 CDD:302697 81/226 (36%)
NHL repeat 1944..1983 CDD:271320 10/38 (26%)
LY 1978..2018 CDD:214531 23/39 (59%)
NHL repeat 1988..2025 CDD:271320 22/36 (61%)
NHL repeat 2029..2070 CDD:271320 15/40 (38%)
Ldl_recept_b 2039..2079 CDD:278487 13/39 (33%)
LY 2064..2106 CDD:214531 16/42 (38%)
NHL repeat 2073..2111 CDD:271320 15/38 (39%)
NHL repeat 2120..2159 CDD:271320 11/38 (29%)
FXa_inhibition 2178..2213 CDD:373209 19/36 (53%)
Ldl_recept_b 2361..2402 CDD:278487 12/40 (30%)
LY 2386..2428 CDD:214531 7/41 (17%)
LDLa 2545..2574 CDD:238060 4/28 (14%)
LDLa 2583..2617 CDD:238060 5/33 (15%)
LDLa 2622..2656 CDD:238060 10/33 (30%)
LDLa 2676..2705 CDD:238060 11/28 (39%)
LDLa 2713..2747 CDD:238060 15/33 (45%)
LDLa 2751..2784 CDD:238060 14/34 (41%)
LDLa 2791..2824 CDD:197566
LDLa 2875..2908 CDD:197566
LDLa 2922..2956 CDD:238060
LDLa 63..95 CDD:238060
LDLa 107..140 CDD:197566
FXa_inhibition 194..224 CDD:373209
LY 314..346 CDD:214531
LY 350..392 CDD:214531
LY 394..435 CDD:214531
FXa_inhibition 514..547 CDD:373209
LY 580..621 CDD:214531
LY 622..661 CDD:214531
LY 668..717 CDD:214531
LY 718..760 CDD:214531
FXa_inhibition 829..864 CDD:373209
LDLa 917..950 CDD:238060
LDLa 957..989 CDD:197566
LDLa 1000..1033 CDD:238060
LDLa 1037..1070 CDD:238060
LDLa 1084..1119 CDD:238060
Ldl_recept_a 1131..1162 CDD:365841
cEGF 2979..3002 CDD:372248
EGF_CA 2999..3033 CDD:214542
LY 3066..3110 CDD:214531
LY 3111..3149 CDD:214531
LY 3154..3195 CDD:214531
LY 3198..3237 CDD:214531
FXa_inhibition 3308..3344 CDD:373209
LDLa 3348..3379 CDD:197566
LDLa 3388..3422 CDD:238060
LDLa 3427..3462 CDD:238060
LDLa 3467..3502 CDD:238060
LDLa 3507..3541 CDD:238060
LDLa 3546..3580 CDD:238060
LDLa 3584..3618 CDD:238060
LDLa 3625..3659 CDD:238060
LDLa 3663..3698 CDD:238060
LDLa 3705..3737 CDD:238060
LDLa 3746..3782 CDD:238060
LDLa 3793..3827 CDD:238060
EGF_CA 3875..3909 CDD:214542
NHL 3972..4204 CDD:302697
NHL repeat 4002..4039 CDD:271320
NHL repeat 4060..4098 CDD:271320
Ldl_recept_b 4070..4110 CDD:393440
LY 4094..4133 CDD:214531
NHL repeat 4148..4186 CDD:271320
EGF_CA 4281..4315 CDD:238011
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167845808
Domainoid 1 1.000 56 1.000 Domainoid score I10969
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.640

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