DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and mgl

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:NP_001096924.2 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster


Alignment Length:1541 Identity:429/1541 - (27%)
Similarity:693/1541 - (44%) Gaps:256/1541 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 NTPATLLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNL----VCWTDSGREIIE 144
            :|.|.|:.:.||.|.||:: :..|..::.:||.::...       |.|:    :.|:|       
  Fly  1558 HTAAFLIISNRHSILVADL-KEQGLERVPIIVENVVAT-------ASNMHTGTIFWSD------- 1607

  Fly   145 CAQTNSSALQPLLRAPK----QTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQK 205
                  ..|:.:.|..:    |.:|:||||..||||.||....:||.|.:.|.|||:..:|..:.
  Fly  1608 ------MKLKKISRLDRGMEPQEIINTGLDLVEGLAYDWIAQNLYWLDSKLNTIEVSAENGSNRL 1666

  Fly   206 VLFWTDLDQPRAVAV--VPARKLLIWTDWGEYPKIERASMDGDPLSRMTLVKEHVFWPNGLAVDL 268
            ||...::.|||.:.:  .|..:.:.||||||.|::||..|||  ..|.|::...::|||||.:|:
  Fly  1667 VLVRENITQPRGMCIDPSPGARWIFWTDWGENPRVERIGMDG--TMRKTIINTKIYWPNGLTLDI 1729

  Fly   269 KNELIYWTDGKHHFIDVMRLDGSSRRTIV---NNLKYPFSLTFYDDRLYWTDWQRGSLNALDLQT 330
            ..:.:|:.|.|..|||....:|:.|:.::   :.|.:|.||:.::|.|||||             
  Fly  1730 ATKRVYFADSKLDFIDFCYYNGTGRQQVLASSHYLLHPHSLSLFEDTLYWTD------------- 1781

  Fly   331 RELKELIDTPK--------------APNSVRAWDPSLQPYEDNPCAHNNGNCSHLCLLATNS-QG 380
            |:|..::...|              .|.|:.....||||...||||  ...|.|||||:.:: :|
  Fly  1782 RQLNRVLSANKFRGKNQTVVSHLISQPLSIHVHHASLQPMTPNPCA--GSRCQHLCLLSPSAPEG 1844

  Fly   381 FSCACPTGVKLISANTCANGSQEMMFIVQRTQISKISLDSPDYTIFPL-PLGKVKYAIAIDYDPV 444
            :||.|..|.||:|...|.......:.:|:.|||..:.|:..|.....| |:..::.:..:|:|..
  Fly  1845 YSCKCRPGFKLLSEGRCIEEENPFLMVVKGTQIVDLPLNGGDARAGALAPVIGIESSTGLDFDRK 1909

  Fly   445 EEHIYW-----SDVETYTIKRAHADGTGVTDFVTSE---VRHPDGLALDWLARNLYWTDTVTDRI 501
            .|.:||     .|.|..||......|...|.|:..|   |..|..:|.|||.||||..:.|...|
  Fly  1910 GETLYWVQGREDDDENCTIYTTPYGGGNKTLFLGIENGIVGAPYTIAFDWLGRNLYIGNRVASNI 1974

  Fly   502 EVCRLDGTAR-KVLIYEH------LEEPRAIAVAPSLGWMFWSDWN--ERKPKVERASLDGSERV 557
            |..|:||..: :.:|..:      :..|:.||:.|:.|.:||.|..  |...|:.|..::|...:
  Fly  1975 EAVRVDGKQKYRTIILANDGYPNSVSRPKQIALDPTEGKLFWIDEGVLEVPIKIGRVDMNGQNPI 2039

  Fly   558 VLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVI---SDNLKHLFGLSILDDY 619
            |:..| ...|..:|:|.|.|.:|:.......|.|.:.:|....:::   |..:.....|.|||..
  Fly  2040 VVFQE-FAHPESLAVDTEKKMVYYSASNPAVIGVMDYNGDDHTLILMKDSHPMAKPRSLGILDHR 2103

  Fly   620 LYWTD--WQR-RSIDRAHKITGNNRIVVVDQYPDLMGLKVTRLREVRGQNACAVRNGGCSHLCLN 681
            ||:.|  ::| ..||..|   |:|...:||...||..:.:.:.|.:. |:.|...||||.|||:.
  Fly  2104 LYYLDPLYERIVRIDLPH---GDNPKTIVDNESDLRSMMIYKKRALM-QHPCQTNNGGCKHLCIP 2164

  Fly   682 RP-RDYVCRCAIDYELANDKRTCVVPAAFLLFSRQEHIGRISIEYNEGNHNDERIPFKDVRDAHA 745
            .| ....|.|.|.|...|: ..||....|.:.|:.:.|.    .|:..:.::..:|... ...|.
  Fly  2165 GPGATRTCACGIGYRKENE-INCVAYKIFAVVSQLDMIR----GYSLSDSSEAMVPISG-PGHHI 2223

  Fly   746 L--DVSVAERRIYWTDQKS---KCIFRAFLNGSYVQRIVDSGLIGPDGI---AVDWLANNIYWSD 802
            |  ||...|:.|||.:...   ..|||:..||:.:|.:|..| ||.:||   .:||:|.|:|:::
  Fly  2224 LHVDVMYREQWIYWAEYNRGYWNGIFRSRPNGTDLQHVVKDG-IGSNGIRGLTIDWVAGNMYFTN 2287

  Fly   803 A--EARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTE-SPTDSIRRAAMDGSDLQTI 864
            .  ....:||..||||:|:||:....:.||.|.:.|.:..:||.: .....|.:|.:|||....:
  Fly  2288 VYPHENYVEVCWLDGSNRKVLVKTTTDAPRELAVNPIKRLLYWIDYGQHPRIGKALLDGSKWTPL 2352

  Fly   865 V-AGANHAAGLTFDQETRRLYWATQSRPAKIESADWDGKKRQILVGSDMDEPYAVSLYQDYVYWS 928
            | :|.:....||.|.:|..:|| ..|:...|:...::|..|:| :..|:..|..:::|.:.|||.
  Fly  2353 VTSGISLPRDLTIDMQTHDIYW-VDSKLDTIQKISYNGANRKI-IRRDLPNPMGIAVYLNDVYWV 2415

  Fly   929 DWNTGDIERVHK-TTGQNRSLVHSGMTYITSLLVF--NDKRQTGVNPC-KVNNGGCSHLCLAQP- 988
            |.|...:.:..| :..:..:.|.:.:..:..:.::  |::.|...||| .:.||||..||.:.| 
  Fly  2416 DRNLMTVFKASKHSANETATSVRTNLEKLRDIAIYNINNQPQDDTNPCAHLGNGGCDQLCFSFPP 2480

  Fly   989 --------GRRGMTCACPTHYQLAKDGVSCIPPRNYIIFSQRNCFG--RLLPNTTDCPNIPLPVS 1043
                    |.|...|.|.|. :|:.|...|.....|::|:.|....  .|.|::|:.|..|| .:
  Fly  2481 DGGASGTSGGRNFRCECATG-KLSADERKCEVVNEYLVFATRTEIRAVNLDPHSTEVPFTPL-TN 2543

  Fly  1044 GKNIRAVDYDPITHHIYWIEGRSHS----IKRSLANGTKVSLLANSG-QPFDLAIDIIGRLLFWT 1103
            ..|:..:|:|...:.:.:.:.|..:    .|.:......::::.|.| .|..:|.|...:.::||
  Fly  2544 LTNVVGLDFDFAHNRMLYTQIRPWAKIAYTKANKPGHDDITVVLNKGINPEGIAYDWTQQKIYWT 2608

  Fly  1104 CSQSNSINVTSFLGESVGVIDTGDSEKPRNIAVHAMKRLLFWTD---VGSHQAIIRARVDGN-ER 1164
            .|.:|||...:..|..:.:|  ...|:||.|.:......||:||   .|:...|.|..:.|: :|
  Fly  2609 DSSNNSIYAMNLDGSELVMI--ARVERPRAIVLDPCNGTLFFTDWGRFGTSGKIFRTTMAGSLKR 2671

  Fly  1165 VELAYKLEGVTALALDQQSDMIYY--AHGKRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYW 1227
            ..:...|...:.||:|.....:|:  |..::|:..|::|:|::.||:..| ....|.....::||
  Fly  2672 AIVDKDLSQPSGLAIDYDERRLYWTDAVREKIERSDLDGQNRELLVAATI-YPFAITVFRNYIYW 2735

  Fly  1228 LD-DKTGVERITVNGERRSAEL-QRL---PQITDIRAVWTPDPKVLRNHTCMHSRTKCSHIC--- 1284
            .| ...||.|...:......|: :||   |:  ||| :::.|.:....:.|..:...|:..|   
  Fly  2736 TDLQLRGVYRAEKHTGANMVEMVKRLEDSPR--DIR-IYSSDRQKCNVNPCRINNGGCAQSCHPA 2797

  Fly  1285 ---------------IASGEGIARTRDVCS----------CPKHLMLLEDKENCG---------- 1314
                           :..|...|...:.|.          |...:...:..::||          
  Fly  2798 PNGKAECKCDDSTKVVNEGRMCAPRNNTCEASKFYCKNGRCISRMWSCDGDDDCGDNSDEDPNYC 2862

  Fly  1315 AFPACGPDHFTCAAPVSGISDVNKDCIPASWRCDGQKDCPDKSDEVGC--PTCRADQFSCQSGEC 1377
            |:.:|.|:.|.|.         |..||..||:||.:.||.|.|||:||  |.|...:|:|.:|.|
  Fly  2863 AYHSCSPNEFRCN---------NGRCIFKSWKCDHENDCKDGSDELGCVYPPCVDGEFTCANGRC 2918

  Fly  1378 IDKSLVCDG-------------------TTNCANGH---DEADCCKRP----------------- 1403
            |.::.||:|                   .|.|...|   ::.:.|..|                 
  Fly  2919 IPQAQVCNGVNDCKDNATSDETHERCPMNTTCPANHLKCEKTNICVEPYWLCDGDNDCGDNSDED 2983

  Fly  1404 -----------GEFQCPINKLCISAALLCDGWENCADGADESSDIC 1438
                       ..|:|| |..||.|...|||.::|.|||||..|.|
  Fly  2984 PLHCGQRTCPTNSFRCP-NHRCIPATWYCDGDDDCGDGADEPPDYC 3028

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 19/38 (50%)
NHL 168..503 CDD:302697 122/363 (34%)
NHL repeat 172..237 CDD:271320 26/66 (39%)
LY 252..293 CDD:214531 14/40 (35%)
NHL repeat 261..298 CDD:271320 13/39 (33%)
NHL repeat 303..339 CDD:271320 11/35 (31%)
NHL repeat 341..419 CDD:271320 30/92 (33%)
NHL repeat 428..476 CDD:271320 15/56 (27%)
LY 472..511 CDD:214531 17/41 (41%)
NHL repeat 477..503 CDD:271320 11/25 (44%)
Ldl_recept_b 534..573 CDD:278487 11/40 (28%)
LY 558..599 CDD:214531 11/40 (28%)
LY 600..641 CDD:214531 13/46 (28%)
FXa_inhibition 668..703 CDD:291342 14/35 (40%)
LY 739..773 CDD:214531 12/38 (32%)
LY 776..818 CDD:214531 18/46 (39%)
LY 819..860 CDD:214531 12/41 (29%)
FXa_inhibition 973..1010 CDD:291342 15/46 (33%)
LY 1122..1164 CDD:214531 13/45 (29%)
FXa_inhibition 1273..1313 CDD:291342 7/67 (10%)
LDLa 1319..1362 CDD:238060 17/42 (40%)
LDLa 1365..1399 CDD:238060 12/55 (22%)
LDLa 1399..1433 CDD:197566 16/61 (26%)
mglNP_001096924.2 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:294047
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:291342
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:278486
LDLa 1227..1259 CDD:197566
LDLa 1268..1303 CDD:238060
LDLa 1308..1343 CDD:238060
LDLa 1356..1387 CDD:238060
LDLa 1391..1423 CDD:197566
LDLa 1435..1469 CDD:197566
FXa_inhibition 1478..1513 CDD:291342
FXa_inhibition 1522..1553 CDD:291342
LY 1625..1665 CDD:214531 19/39 (49%)
LY 1667..1711 CDD:214531 18/45 (40%)
Ldl_recept_b 1690..1728 CDD:278487 19/39 (49%)
LY 1712..1754 CDD:214531 14/41 (34%)
LY 1986..2037 CDD:214531 13/50 (26%)
FXa_inhibition 2151..>2179 CDD:291342 12/27 (44%)
LY 2259..2305 CDD:214531 18/46 (39%)
Ldl_recept_b 2326..2366 CDD:278487 11/39 (28%)
LY 2352..2392 CDD:214531 11/40 (28%)
NHL 2579..>2711 CDD:302697 34/133 (26%)
NHL repeat 2593..2622 CDD:271320 9/28 (32%)
NHL repeat 2634..2678 CDD:271320 12/43 (28%)
LY 2671..2713 CDD:214531 10/41 (24%)
LDLa 2867..2901 CDD:238060 17/42 (40%)
LDLa 2906..2941 CDD:238060 9/34 (26%)
LDLa 2950..2983 CDD:238060 4/32 (13%)
LDLa 3034..3066 CDD:197566
LDLa 3080..3115 CDD:197566
LDLa 3128..3159 CDD:238060
LDLa 3170..3204 CDD:238060
LDLa 3210..3242 CDD:197566
cEGF 3269..3292 CDD:289433
vWFA <3284..3324 CDD:294047
LY 3362..3394 CDD:214531
LY 3406..3448 CDD:214531
LY 3498..3536 CDD:214531
LY 3536..3578 CDD:214531
FXa_inhibition 3607..3659 CDD:291342
LDLa 3663..3696 CDD:238060
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4390 CDD:278487
NHL repeat 4376..4422 CDD:271320
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45461708
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.640

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