Protein Alignment arr and LRP8

DIOPT Version :10

• Sequence 1: NP_524737.2
• Gene: arr / 44279
• FlyBaseID: FBgn0000119
• Length: 1678
• Species: Drosophila melanogaster
• Sequence 2: NP_004622.2
• Gene: LRP8 / 7804
• HGNCID: 6700
• Length: 963
• Species: Homo sapiens
• Alignment Length: 45
• Identity: 10/45 - (22%)
• Similarity: 22/45 - (48%)
• Gaps: 16/45 - (35%)

  Fly     7 KDHQAKQAAKKEDQE-------------RRRKEAIMSANELTQNL 38
            |...:::.|::|::|             .|:||.:   :::|.||
Human   207 KRKASRKGAEEEEEEEDDDSEEEIKAIRERQKEEL---SKVTSNL 248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
arr	NP_524737.2	LY	162..201	CDD:214531
		NHL	168..503	CDD:302697
		NHL repeat	172..237	CDD:271320
		LY	252..293	CDD:214531
		NHL repeat	261..298	CDD:271320
		NHL repeat	303..339	CDD:271320
		NHL repeat	341..419	CDD:271320
		NHL repeat	428..476	CDD:271320
		LY	472..511	CDD:214531
		NHL repeat	477..503	CDD:271320
		Ldl_recept_b	534..574	CDD:459654
		LY	558..599	CDD:214531
		LY	600..641	CDD:214531
		FXa_inhibition	668..703	CDD:464251
		YncE	<736..886	CDD:442618
		LY	776..818	CDD:214531
		LY	905..946	CDD:214531
		FXa_inhibition	973..1010	CDD:464251
		YncE	<1047..1191	CDD:442618
		LDLa	1319..1362	CDD:238060
		LDLa	1365..1399	CDD:238060
		LDLa	1399..1433	CDD:197566
LRP8	NP_004622.2	LDLa	47..81	CDD:238060
		LDLa	85..117	CDD:197566
		LDLa	127..163	CDD:238060
		LDLa	206..240	CDD:197566	6/32 (19%)
		Ldl_recept_a	262..294	CDD:395011
		Ldl_recept_a	298..333	CDD:395011
		FXa_inhibition	340..374	CDD:464251
		EGF_CA	376..406	CDD:214542
		LY	445..480	CDD:214531
		LDL-receptor class B 1	462..508
		LY	489..531	CDD:214531
		LDL-receptor class B 2	509..551
		LDL-receptor class B 3	552..595
		Ldl_recept_b	552..592	CDD:459654
		LY	576..618	CDD:214531
		LDL-receptor class B 4	596..639
		Ldl_recept_b	639..679	CDD:459654
		LDL-receptor class B 5	640..681
		FXa_inhibition	697..734	CDD:464251
		Clustered O-linked oligosaccharides	740..798
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	754..815