DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment arr and VLDLR

DIOPT Version :9

Sequence 1:	NP_524737.2	Gene:	arr / 44279	FlyBaseID:	FBgn0000119	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	NP_003374.3	Gene:	VLDLR / 7436	HGNCID:	12698	Length:	873	Species:	Homo sapiens

Alignment Length:	455	Identity:	135/455 - (29%)
Similarity:	205/455 - (45%)	Gaps:	71/455 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 ELIDTPKAPN---SVRAW-DPSLQPYEDNPCAHNNGNCSHLC--LLATNSQGFSCACPTGVKLIS 393
            |.||..|..|   ..|.| |..|:....|.|..|||.|||:|  |:.    |:.|.|..|.:||.
Human   330 ECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVI----GYECDCAAGFELID 390

  Fly   394 ANTC-----------------------------------------ANGSQEMMFIVQRTQISKIS 417
            ..||                                         |.|.:..:....|..|.||.
Human   391 RKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIG 455

  Fly   418 LDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHAD---GTGVTDFVTSEVRHP 479
            |:..:|...   :.:::..:|:|.|...:.::|:|:....|..|..|   |..|.  :...|.:|
Human   456 LERKEYIQL---VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVK--MIDNVYNP 515

  Fly   480 DGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERKP 544
            ..:|:||:.:.:||||..:..|.|..||||.||.|....|.||.:|||.|..|:::||||.| ..
Human   516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGE-PA 579

  Fly   545 KVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVIS--DNL 607
            |:|:|.::|.:|..||:.::.|||||.||:....:||.|.|...:...:::|..||:|:.  :.|
Human   580 KIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFL 644

  Fly   608 KHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGLKV-TRLREVRGQNACA-- 669
            .|...|:|.:|.:||.|.:..::..|:|.||:....:|:...|...:.| ..|.:..|:|.|.
Human   645 AHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEED 709

  Fly   670 VRNGGCSHLCLNRPR------DYVCRCAIDYELANDKRTCVVPAAFLLFSRQEHIGRISIEYNEG 728
            :.||||.:|||..|:      .|.|.|...|.:..:.|.|...|..:.:|..:......|....|
Human   710 MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSG 774

Fly 729 728
Human 775 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arr	NP_524737.2	LY	162..201	CDD:214531
		NHL	168..503	CDD:302697	55/217 (25%)
		NHL repeat	172..237	CDD:271320
		LY	252..293	CDD:214531
		NHL repeat	261..298	CDD:271320
		NHL repeat	303..339	CDD:271320	2/3 (67%)
		NHL repeat	341..419	CDD:271320	30/124 (24%)
		NHL repeat	428..476	CDD:271320	10/50 (20%)
		LY	472..511	CDD:214531	15/38 (39%)
		NHL repeat	477..503	CDD:271320	9/25 (36%)
		Ldl_recept_b	534..573	CDD:278487	17/38 (45%)
		LY	558..599	CDD:214531	14/40 (35%)
		LY	600..641	CDD:214531	14/42 (33%)
		FXa_inhibition	668..703	CDD:291342	14/42 (33%)
		LY	739..773	CDD:214531
		LY	776..818	CDD:214531
		LY	819..860	CDD:214531
		FXa_inhibition	973..1010	CDD:291342
		LY	1122..1164	CDD:214531
		FXa_inhibition	1273..1313	CDD:291342
		LDLa	1319..1362	CDD:238060
		LDLa	1365..1399	CDD:238060
		LDLa	1399..1433	CDD:197566
VLDLR	NP_003374.3	LDLa	33..67	CDD:238060
		LDLa	71..103	CDD:197566
		Ldl_recept_a	111..149	CDD:278486
		LDLa	154..188	CDD:238060
		Ldl_recept_a	192..224	CDD:278486
		Ldl_recept_a	237..273	CDD:278486
		Ldl_recept_a	276..312	CDD:278486
		Ldl_recept_a	320..350	CDD:278486	7/19 (37%)
		FXa_inhibition	360..394	CDD:291342	15/37 (41%)
		EGF_CA	396..426	CDD:214542	0/29 (0%)
		Ldl_recept_b	481..521	CDD:278487	10/41 (24%)
		LY	505..547	CDD:214531	16/43 (37%)
		Ldl_recept_b	568..608	CDD:278487	18/40 (45%)
		LY	592..634	CDD:214531	14/41 (34%)
		Ldl_recept_b	655..694	CDD:278487	10/38 (26%)
		FXa_inhibition	706..749	CDD:291342	14/42 (33%)
		Mucin	<751..813	CDD:250634	4/24 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155338
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740