Sequence 1: | NP_524737.2 | Gene: | arr / 44279 | FlyBaseID: | FBgn0000119 | Length: | 1678 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_003096.2 | Gene: | SORL1 / 6653 | HGNCID: | 11185 | Length: | 2214 | Species: | Homo sapiens |
Alignment Length: | 1599 | Identity: | 332/1599 - (20%) |
---|---|---|---|
Similarity: | 501/1599 - (31%) | Gaps: | 642/1599 - (40%) |
- Green bases have known domain annotations that are detailed below.
Fly 91 FTTRHDIQ---VANITRPTGGPQIDVIVRD--------LAEAMAIDFYYA-KNLVCWTDSGREII 143
Fly 144 ECAQTNSSALQPLLRAPKQTVISTGLDKP-------EGLAMDWYTDKIYWTDGEKNRIEVATLDG 201
Fly 202 RYQKVLFWTDLDQPRAVAVVPARKLLIWTDWGE----------------------------YPKI 238
Fly 239 ERASMDG-----DPLSRMTLVKEHVFWPNGLAVDLKNEL---IYWTDGKHHFIDVMRLDGSSRRT 295
Fly 296 IVNNLKYP-----------FS---------LT-----------FYDDRLYWTDWQRGSLNALDLQ 329
Fly 330 TRELKELIDTPKAPNSVRAWDPSLQ-----------------PYE--------DNPCAHNNGNCS 369
Fly 370 ------------------HLCLLATNSQGFSCA----CPT--------GVKLISANTCANG---- 400
Fly 401 -----------SQEMMFIVQRTQISKISLDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDVE 454
Fly 455 TYTIKRAHADG-TGVTDFVTSEVRHPDGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEH 518
Fly 519 -LEEPRAIAVAPSLGWMFWSDWNERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWC 582
Fly 583 DGKTDKIEVANMDGSGRRVVISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQ 647
Fly 648 YPDLMGLKVTRLREVRGQNACAVRNGGCSHLCL---NRPR----------------DYVCRCAID 693
Fly 694 YELANDKRTCVVPAAFLLFSRQEHIGRISIEYNEGNHNDERIPFKDVRDAHALDVSVAERRIYWT 758
Fly 759 DQKSKCIFRAFLNGSYVQRIVDSGLIGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLW 823
Fly 824 KGVEEPRSLVLEPRRGYMYWTESPTDSIRRAAMDGSDLQTIVAGANHAAGLTFDQETRRLYWATQ 888
Fly 889 SRPAKIESADWDGKKRQILVGSDMDEPYAVSLYQDYVYWSDWNTGD-IERVHKTTGQNRSLVH-- 950
Fly 951 -SGMTYITSLLVFNDKRQTGVNPCK--VNNGGCS---HLCLAQPGRRGMTCACPTHYQLAKDGVS 1009
Fly 1010 CIPPRNYIIFSQRNCFGRLLPNTTDCPNIPLPVSGKNIRAVDYDPITHHIYWIEGRSHSIKRSLA 1074
Fly 1075 NGTKVSLLANSGQPFDLAIDIIGRLLFWTCSQSNSINVTSFLGESVGVIDTGDSEKPRNIAVHAM 1139
Fly 1140 -------KRLLFWTDVGSHQAIIRARVDGNERVELAYKLEGVTALALDQQSDMIYYAHGKRIDAI 1197
Fly 1198 DINGKNKKTLVSMHISQVINIAALGGFVYWLDDKTGVERITVNGERRSAELQRLPQITDIRAVWT 1262
Fly 1263 PDPKVLRNHTCMHSRTKCSHICIASGEGIARTRDVCSCPKHLMLLEDKENCGAFPACGPD----- 1322
Fly 1323 HFTCAAPVSGISDVNKDCIPASWRCDGQKDCPDKSDEVGC-------------PTCRADQFSCQS 1374
Fly 1375 GECIDKSLVCDGTTNCANGHDEADC-----------------CKRPGEFQCPINKLCISAALLCD 1422
Fly 1423 GWENCADGADE------SSDICLQRRMAPATDKRAFMIL 1455 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
arr | NP_524737.2 | LY | 162..201 | CDD:214531 | 10/45 (22%) |
NHL | 168..503 | CDD:302697 | 93/479 (19%) | ||
NHL repeat | 172..237 | CDD:271320 | 17/99 (17%) | ||
LY | 252..293 | CDD:214531 | 9/43 (21%) | ||
NHL repeat | 261..298 | CDD:271320 | 7/39 (18%) | ||
NHL repeat | 303..339 | CDD:271320 | 9/66 (14%) | ||
NHL repeat | 341..419 | CDD:271320 | 24/147 (16%) | ||
NHL repeat | 428..476 | CDD:271320 | 17/48 (35%) | ||
LY | 472..511 | CDD:214531 | 13/38 (34%) | ||
NHL repeat | 477..503 | CDD:271320 | 8/25 (32%) | ||
Ldl_recept_b | 534..573 | CDD:278487 | 20/38 (53%) | ||
LY | 558..599 | CDD:214531 | 17/40 (43%) | ||
LY | 600..641 | CDD:214531 | 15/40 (38%) | ||
FXa_inhibition | 668..703 | CDD:291342 | 15/53 (28%) | ||
LY | 739..773 | CDD:214531 | 2/33 (6%) | ||
LY | 776..818 | CDD:214531 | 4/41 (10%) | ||
LY | 819..860 | CDD:214531 | 0/40 (0%) | ||
FXa_inhibition | 973..1010 | CDD:291342 | 7/41 (17%) | ||
LY | 1122..1164 | CDD:214531 | 12/48 (25%) | ||
FXa_inhibition | 1273..1313 | CDD:291342 | 7/39 (18%) | ||
LDLa | 1319..1362 | CDD:238060 | 16/47 (34%) | ||
LDLa | 1365..1399 | CDD:238060 | 14/33 (42%) | ||
LDLa | 1399..1433 | CDD:197566 | 15/50 (30%) | ||
SORL1 | NP_003096.2 | Cell attachment site. /evidence=ECO:0000255 | 63..65 | ||
VPS10 | 124..753 | CDD:214740 | 79/463 (17%) | ||
BNR 1 | 136..147 | ||||
BNR 2 | 232..243 | ||||
BNR 3 | 441..452 | 5/14 (36%) | |||
BNR 4 | 521..532 | 0/10 (0%) | |||
BNR 5 | 562..573 | 2/10 (20%) | |||
LY | 780..821 | CDD:214531 | 14/40 (35%) | ||
LDL-receptor class B 1 | 800..843 | 12/42 (29%) | |||
LY | 824..866 | CDD:214531 | 13/41 (32%) | ||
LDL-receptor class B 2 | 844..887 | 15/42 (36%) | |||
LY | 868..910 | CDD:214531 | 15/41 (37%) | ||
LDL-receptor class B 3 | 888..932 | 22/45 (49%) | |||
Ldl_recept_b | 890..929 | CDD:278487 | 20/38 (53%) | ||
LY | 913..953 | CDD:214531 | 17/41 (41%) | ||
LDL-receptor class B 4 | 933..970 | 13/37 (35%) | |||
LDL-receptor class B 5 | 971..1013 | 14/41 (34%) | |||
LDLa | 1078..1112 | CDD:238060 | 12/171 (7%) | ||
LDLa | 1120..1153 | CDD:238060 | 8/40 (20%) | ||
Ldl_recept_a | 1157..1192 | CDD:278486 | 10/40 (25%) | ||
LDLa | 1198..1230 | CDD:197566 | 13/68 (19%) | ||
LDLa | 1240..1271 | CDD:238060 | 10/63 (16%) | ||
LDLa | 1281..1308 | CDD:197566 | 8/37 (22%) | ||
LDLa | 1325..1359 | CDD:238060 | 10/83 (12%) | ||
LDLa | 1373..1403 | CDD:238060 | 15/38 (39%) | ||
LDLa | 1419..1453 | CDD:238060 | 14/33 (42%) | ||
LDLa | 1471..1506 | CDD:238060 | 16/35 (46%) | ||
LDLa | 1513..1546 | CDD:197566 | 5/19 (26%) | ||
FN3 | 1557..>1628 | CDD:238020 | |||
FN3 | 1651..1742 | CDD:238020 | |||
FN3 | 1749..1829 | CDD:214495 | |||
FN3 | 1934..2021 | CDD:238020 | |||
FN3 | 2025..2112 | CDD:238020 | |||
Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000305|PubMed:16531402 | 2161..2164 | ||||
Endocytosis signal. /evidence=ECO:0000255 | 2172..2177 | ||||
Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000269|PubMed:17646382 | 2190..2214 | ||||
Required for interaction with GGA1 and GGA2. /evidence=ECO:0000269|PubMed:11821067 | 2201..2214 | ||||
DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000269|PubMed:20015111 | 2208..2212 | ||||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_KOG1215 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
2 | 1.810 |