DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and SORL1

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:NP_003096.2 Gene:SORL1 / 6653 HGNCID:11185 Length:2214 Species:Homo sapiens


Alignment Length:1599 Identity:332/1599 - (20%)
Similarity:501/1599 - (31%) Gaps:642/1599 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 FTTRHDIQ---VANITRPTGGPQIDVIVRD--------LAEAMAIDFYYA-KNLVCWTDSGREII 143
            |.|||.|.   :|:.:.    .|:.|.|..        ::||..:.|..: :|::.::..|    
Human   340 FVTRHPINEYYIADASE----DQVFVCVSHSNNRTNLYISEAEGLKFSLSLENVLYYSPGG---- 396

  Fly   144 ECAQTNSSALQPLLRAPKQTVISTGLDKP-------EGLAMDWYTDKIYWTDGEKNRIEVATLDG 201
                           |...|::....::|       |||...:....|..:..|:|...|.|.| 
Human   397 ---------------AGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFD- 445

  Fly   202 RYQKVLFWTDLDQPRAVAVVPARKLLIWTDWGE----------------------------YPKI 238
               |...|..|..|            .:|.:||                            .|.:
Human   446 ---KGGTWEFLQAP------------AFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPIL 495

  Fly   239 ERASMDG-----DPLSRMTLVKEHVFWPNGLAVDLKNEL---IYWTDGKHHFIDVMRLDGSSRRT 295
            .:.|..|     ..:.:....|.:|:..:......:..|   .|:|.|.|..|......|..   
Human   496 SKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGME--- 557

  Fly   296 IVNNLKYP-----------FS---------LT-----------FYDDRLYWTDWQRGSLNALDLQ 329
             .|.|||.           ||         ||           |..::.....|....:||.|  
Human   558 -TNELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHSWLILQVNATD-- 619

  Fly   330 TRELKELIDTPKAPNSVRAWDPSLQ-----------------PYE--------DNPCAHNNGNCS 369
                  .:..|...|..:.|.||.:                 |:.        |.|...:|.:|:
Human   620 ------ALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCT 678

  Fly   370 ------------------HLCLLATNSQGFSCA----CPT--------GVKLISANTCANG---- 400
                              .:|:......|.|.:    ||.        |.:.||.:||:.|    
Human   679 REDYECDFGFKMSEDLSLEVCVPDPEFSGKSYSPPVPCPVGSTYRRTRGYRKISGDTCSGGDVEA 743

  Fly   401 -----------SQEMMFIVQRTQISKISLDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDVE 454
                       ::|..||:...:.|....|........|||..::.|:|:|:|.....:||||:.
Human   744 RLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLA 808

  Fly   455 TYTIKRAHADG-TGVTDFVTSEVRHPDGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEH 518
            ...|:|...:| ||....:.|.:...:.||.:.|::.|||.|....:|||...||..|..::...
Human   809 LDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSS 873

  Fly   519 -LEEPRAIAVAPSLGWMFWSDWNERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWC 582
             |:.|||:.:.|..|.|||:||.:.||.:.|:::|||....||||::.|||||::|  .:.|||.
Human   874 VLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWT 936

  Fly   583 DGKTDKIEVANMDGSGRRVVISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQ 647
            |...:.||.....|..|.|:: |||.|.:.:::..:.:||.||.:.||.||.|.:|:...::.:|
Human   937 DAYLECIERITFSGQQRSVIL-DNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQ 1000

  Fly   648 YPDLMGLKVTRLREVRGQNACAVRNGGCSHLCL---NRPR----------------DYVCRCAID 693
            ...||.:|:....:..|.|||..|  .||.|||   |..|                |.:|.|...
Human  1001 LTGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQG 1063

  Fly   694 YELANDKRTCVVPAAFLLFSRQEHIGRISIEYNEGNHNDERIPFKDVRDAHALDVSVAERRIYWT 758
            |:|.|:  |||         :||:. .:..:|...|.|                           
Human  1064 YQLKNN--TCV---------KQENT-CLRNQYRCSNGN--------------------------- 1089

  Fly   759 DQKSKCIFRAFLNGSYVQRIVDSGLIGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLW 823
                 ||                              |:|:|.|                     
Human  1090 -----CI------------------------------NSIWWCD--------------------- 1098

  Fly   824 KGVEEPRSLVLEPRRGYMYWTESPTDSIRRAAMDGSDLQTIVAGANHAAGLTFDQETRRLYWATQ 888
                                                                ||.:...:   :.
Human  1099 ----------------------------------------------------FDNDCGDM---SD 1108

  Fly   889 SRPAKIESADWDGKKRQILVGSDMDEPYAVSLYQDYVYWSDWNTGD-IERVHKTTGQNRSLVH-- 950
            .|.......|.|.:.|....|:.:...|...|..|        .|| .:..|....|.||..:  
Human  1109 ERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDD--------CGDNSDESHCEMHQCRSDEYNC 1165

  Fly   951 -SGMTYITSLLVFNDKRQTGVNPCK--VNNGGCS---HLCLAQPGRRGMTCACPTHYQLAKDGVS 1009
             |||...:|.:...|      |.|:  .:...|:   |.|.|            :::| .::| .
Human  1166 SSGMCIRSSWVCDGD------NDCRDWSDEANCTAIYHTCEA------------SNFQ-CRNG-H 1210

  Fly  1010 CIPPRNYIIFSQRNCFGRLLPNTTDCPNIPLPVSGKNIRAVDYDPITHHIYWIEGRSHSIKRSLA 1074
            |||.|       ..|.|     .|||.:           ..|.||:.     .|.:.:..:  ..
Human  1211 CIPQR-------WACDG-----DTDCQD-----------GSDEDPVN-----CEKKCNGFR--CP 1245

  Fly  1075 NGTKVSLLANSGQPFDLAIDIIGRLLFWTCSQSNSINVTSFLGESVGVIDTGDSEKPRNIAVHAM 1139
            |||.:.    |.:..|...|         ||                  |..|.:....:..|.|
Human  1246 NGTCIP----SSKHCDGLRD---------CS------------------DGSDEQHCEPLCTHFM 1279

  Fly  1140 -------KRLLFWTDVGSHQAIIRARVDGNERVELAYKLEGVTALALDQQSDMIYYAHGKRIDAI 1197
                   ::.||.:.|  ...||:.| ||::        |........|..:.            
Human  1280 DFVCKNRQQCLFHSMV--CDGIIQCR-DGSD--------EDAAFAGCSQDPEF------------ 1321

  Fly  1198 DINGKNKKTLVSMHISQVINIAALGGFVYWLDDKTGVERITVNGERRSAELQRLPQITDIRAVWT 1262
                                        :.:.|:.|.:                           
Human  1322 ----------------------------HKVCDEFGFQ--------------------------- 1331

  Fly  1263 PDPKVLRNHTCMHSRTKCSHICIASGEGIARTRDVCSCPKHLMLLEDKENCGAFPACGPD----- 1322
                 .:|..|:....||        :|:    |.|..      ..|:.|| ..|...|:     
Human  1332 -----CQNGVCISLIWKC--------DGM----DDCGD------YSDEANC-ENPTEAPNCSRYF 1372

  Fly  1323 HFTCAAPVSGISDVNKDCIPASWRCDGQKDCPDKSDEVGC-------------PTCRADQFSCQS 1374
            .|.|.         |..|||..|:||.:.||.|.|||..|             .||..:.:.|.|
Human  1373 QFRCE---------NGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSS 1428

  Fly  1375 GECIDKSLVCDGTTNCANGHDEADC-----------------CKRPGEFQCPINKLCISAALLCD 1422
            |.|:..:.||||..:||:|.||..|                 |.| .||:|...|.||.....||
Human  1429 GTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDR-FEFECHQPKTCIPNWKRCD 1492

  Fly  1423 GWENCADGADE------SSDICLQRRMAPATDKRAFMIL 1455
            |.::|.||.||      |:..|:.|.. ...|..|.::|
Human  1493 GHQDCQDGRDEANCPTHSTLTCMSREF-QCEDGEACIVL 1530

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 10/45 (22%)
NHL 168..503 CDD:302697 93/479 (19%)
NHL repeat 172..237 CDD:271320 17/99 (17%)
LY 252..293 CDD:214531 9/43 (21%)
NHL repeat 261..298 CDD:271320 7/39 (18%)
NHL repeat 303..339 CDD:271320 9/66 (14%)
NHL repeat 341..419 CDD:271320 24/147 (16%)
NHL repeat 428..476 CDD:271320 17/48 (35%)
LY 472..511 CDD:214531 13/38 (34%)
NHL repeat 477..503 CDD:271320 8/25 (32%)
Ldl_recept_b 534..573 CDD:278487 20/38 (53%)
LY 558..599 CDD:214531 17/40 (43%)
LY 600..641 CDD:214531 15/40 (38%)
FXa_inhibition 668..703 CDD:291342 15/53 (28%)
LY 739..773 CDD:214531 2/33 (6%)
LY 776..818 CDD:214531 4/41 (10%)
LY 819..860 CDD:214531 0/40 (0%)
FXa_inhibition 973..1010 CDD:291342 7/41 (17%)
LY 1122..1164 CDD:214531 12/48 (25%)
FXa_inhibition 1273..1313 CDD:291342 7/39 (18%)
LDLa 1319..1362 CDD:238060 16/47 (34%)
LDLa 1365..1399 CDD:238060 14/33 (42%)
LDLa 1399..1433 CDD:197566 15/50 (30%)
SORL1NP_003096.2 Cell attachment site. /evidence=ECO:0000255 63..65
VPS10 124..753 CDD:214740 79/463 (17%)
BNR 1 136..147
BNR 2 232..243
BNR 3 441..452 5/14 (36%)
BNR 4 521..532 0/10 (0%)
BNR 5 562..573 2/10 (20%)
LY 780..821 CDD:214531 14/40 (35%)
LDL-receptor class B 1 800..843 12/42 (29%)
LY 824..866 CDD:214531 13/41 (32%)
LDL-receptor class B 2 844..887 15/42 (36%)
LY 868..910 CDD:214531 15/41 (37%)
LDL-receptor class B 3 888..932 22/45 (49%)
Ldl_recept_b 890..929 CDD:278487 20/38 (53%)
LY 913..953 CDD:214531 17/41 (41%)
LDL-receptor class B 4 933..970 13/37 (35%)
LDL-receptor class B 5 971..1013 14/41 (34%)
LDLa 1078..1112 CDD:238060 12/171 (7%)
LDLa 1120..1153 CDD:238060 8/40 (20%)
Ldl_recept_a 1157..1192 CDD:278486 10/40 (25%)
LDLa 1198..1230 CDD:197566 13/68 (19%)
LDLa 1240..1271 CDD:238060 10/63 (16%)
LDLa 1281..1308 CDD:197566 8/37 (22%)
LDLa 1325..1359 CDD:238060 10/83 (12%)
LDLa 1373..1403 CDD:238060 15/38 (39%)
LDLa 1419..1453 CDD:238060 14/33 (42%)
LDLa 1471..1506 CDD:238060 16/35 (46%)
LDLa 1513..1546 CDD:197566 5/19 (26%)
FN3 1557..>1628 CDD:238020
FN3 1651..1742 CDD:238020
FN3 1749..1829 CDD:214495
FN3 1934..2021 CDD:238020
FN3 2025..2112 CDD:238020
Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000305|PubMed:16531402 2161..2164
Endocytosis signal. /evidence=ECO:0000255 2172..2177
Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000269|PubMed:17646382 2190..2214
Required for interaction with GGA1 and GGA2. /evidence=ECO:0000269|PubMed:11821067 2201..2214
DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000269|PubMed:20015111 2208..2212
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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