DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment arr and ldlrad3

DIOPT Version :9

Sequence 1:	NP_524737.2	Gene:	arr / 44279	FlyBaseID:	FBgn0000119	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	NP_001124079.1	Gene:	ldlrad3 / 570705	ZFINID:	ZDB-GENE-030131-1533	Length:	314	Species:	Danio rerio

Alignment Length:	374	Identity:	99/374 - (26%)
Similarity:	145/374 - (38%)	Gaps:	89/374 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1303 HLMLLEDKENCGAFPACGPDHFTCAAPVSGISDVNKDCIPASWRCDGQKDCPDKSDEVGC----P 1363
            :.:|.....:|...|. |...:.|:||.|.:. .:.:|:||:.:|||..||.|:|||.||    .
Zfish     5 YFLLGSGSVDCQVSPG-GNSSWHCSAPGSFMC-ADGECVPAAGQCDGYPDCADRSDERGCLKLKS 67

  Fly  1364 TCRADQFSCQSG-ECIDKSLVCDGTTNCANGHDEADCCKRP-----GEFQCPINKLCISAALLCD 1422
            .|.:..|||.:| .||.....|:|..:|.:|.||.:|...|     ..|.| .|..|:..:.||:
Zfish    68 KCASTFFSCANGVHCIIGRFQCNGFRDCPDGSDEDNCTAHPLLCSSLRFHC-ANGRCVDRSFLCN 131

  Fly  1423 GWENCADGADESSDICLQRRMAP-----ATDKR------AFMILIGATMITIFSIVYLLQFCRTR 1476
            |.:||.|.:||.:  ||....:|     ..|.|      ....:||:.:|.:..:..|......:
Zfish   132 GQDNCQDNSDEEN--CLTTAESPEHMLGTLDYRLRYYPSITYAVIGSAIIFVLVVALLALVLHHQ 194

  Fly  1477 IGKSRTEPKDDQATDPLSPSTLSKSQRVSKIASVADAVRMSTLNSRNSMNSYDRNHITGASSSTT 1541
            ..:|...|                 |||.:     .:.....|.||  :...:|.|:       .
Zfish   195 RKRSVLLP-----------------QRVYR-----GSCHQPLLLSR--LLIVERGHL-------L 228

  Fly  1542 NGSSMVAYPINPPP--SPATR-SRRPYRHYKIINQPPPPTPCSTDICDESDSNYTSKSNSNNSNG 1603
            :.|.....|.:.||  |.|.| |.||.    ..:.||||.|..    |.....|........:.
Zfish   229 HPSRCPGAPADLPPSYSQAVRDSGRPV----WFDLPPPPYPPP----DREPPGYEEPEEPAEAQ- 284

  Fly  1604 GATKHSSSSAAACLQYGYDSEPYPPPPTPRSHYHSDVRIVPESSCPPSP 1652
              |:.|.:|.         .|..|.||:|         .:|.||.||:|
Zfish   285 --TQTSVTSV---------EETPPAPPSP---------ALPSSSSPPAP 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arr	NP_524737.2	LY	162..201	CDD:214531
		NHL	168..503	CDD:302697
		NHL repeat	172..237	CDD:271320
		LY	252..293	CDD:214531
		NHL repeat	261..298	CDD:271320
		NHL repeat	303..339	CDD:271320
		NHL repeat	341..419	CDD:271320
		NHL repeat	428..476	CDD:271320
		LY	472..511	CDD:214531
		NHL repeat	477..503	CDD:271320
		Ldl_recept_b	534..573	CDD:278487
		LY	558..599	CDD:214531
		LY	600..641	CDD:214531
		FXa_inhibition	668..703	CDD:291342
		LY	739..773	CDD:214531
		LY	776..818	CDD:214531
		LY	819..860	CDD:214531
		FXa_inhibition	973..1010	CDD:291342
		LY	1122..1164	CDD:214531
		FXa_inhibition	1273..1313	CDD:291342	1/9 (11%)
		LDLa	1319..1362	CDD:238060	17/42 (40%)
		LDLa	1365..1399	CDD:238060	13/34 (38%)
		LDLa	1399..1433	CDD:197566	12/38 (32%)
ldlrad3	NP_001124079.1	LDLa	30..62	CDD:238060	14/32 (44%)
		LDLa	69..104	CDD:238060	13/34 (38%)
		LDLa	111..145	CDD:238060	12/36 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900