DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment arr and lrp5

DIOPT Version :9

Sequence 1:	NP_524737.2	Gene:	arr / 44279	FlyBaseID:	FBgn0000119	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	XP_009296098.1	Gene:	lrp5 / 568518	ZFINID:	ZDB-GENE-050518-2	Length:	1615	Species:	Danio rerio

Alignment Length:	1694	Identity:	716/1694 - (42%)
Similarity:	1001/1694 - (59%)	Gaps:	155/1694 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 MLIGFLLICFGISNSWQYKNVHMPSSSSLIASPPASAFVNTPATLLFTTRHDIQVANITRPTGGP 109
            :|:..||.|                |.::|...|         .|||..|.|:::.::  ..|..
Zfish    13 LLLELLLCC----------------SLTVIRGSP---------LLLFANRRDVRLVDV--EVGRS 50

  Fly   110 QIDVIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECAQTN--SSALQPLLRAPKQTVISTGLDKP 172
            :..|:|.||.:|.|:||.:::.|:.|||...|.|:....|  :::::.......|||:.:|||.|
Zfish    51 ESAVVVSDLEDAAAVDFLFSEGLIFWTDVSEEAIKQTYYNLSTNSMKEATLGKGQTVVVSGLDSP 115

  Fly   173 EGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAVAVVPARKLLIWTDWGEYPK 237
            :|||.||...|:||||.|.||||||.|||..:|||||.|||||||:|:.|:.:.:.||||||.|:
Zfish   116 DGLACDWLGHKLYWTDSETNRIEVANLDGTSRKVLFWQDLDQPRAIALNPSHRYMYWTDWGEEPR 180

  Fly   238 IERASMDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYWTDGKHHFIDVMRLDGSSRRTIV-NNLK 301
            ||||.|||.  :|..:|::.::|||||.:||..:.:||.|.|..||....|||:||..:| .:|.
Zfish   181 IERAGMDGS--NRQIIVQKQIYWPNGLTIDLDEQKLYWADAKLSFIHRANLDGTSREAVVEGSLT 243

  Fly   302 YPFSLTFYDDRLYWTDWQRGSLNALDLQTREL-KELIDTPKAPNSVRAWDPSLQPYEDNPCAHNN 365
            :||:||.||:.|||||||..|::|.:..:.|. :|:::...:|..::......||....||:..|
Zfish   244 HPFALTLYDETLYWTDWQTRSIHACNKHSGEKHREILNGIYSPMDIQVLGQERQPNIQTPCSERN 308

  Fly   366 GNCSHLCLLATNSQGFSCACPTGVKL-ISANTCANGSQEMMFIVQRTQISKISLDSPDYTIFPLP 429
            |.|||||||:.....:|||||||||| ....||..|:::::.:.:||.:.:||||.||:|...|.
Zfish   309 GGCSHLCLLSPIPPFYSCACPTGVKLKEDGKTCRPGAEQVLLLARRTDLRRISLDLPDFTDIVLQ 373

  Fly   430 LGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHADGTGVTDFVTSEVRHPDGLALDWLARNLYWT 494
            :..:::||||||||||.::||:|.|...|:||..||:.....:|:|:.||||:|:||:|||||||
Zfish   374 VNDIRHAIAIDYDPVEGYVYWTDDELRAIRRARIDGSDAQTLITNEINHPDGIAVDWVARNLYWT 438

  Fly   495 DTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERKPKVERASLDGSERVVL 559
            ||.||||||.||:||:|:|||.|:|:|||||.:.|..|:|:|:||.| .||:|||:|||::||||
Zfish   439 DTGTDRIEVTRLNGTSRRVLISENLDEPRAIVLDPINGYMYWTDWGE-LPKIERANLDGTDRVVL 502

  Fly   560 VSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISDNLKHLFGLSILDDYLYWTD 624
            ::.:||||||:|:|..|..:||.|.|||||||.|:||:.|..::.|.|.|:||.::|.:|:||||
Zfish   503 LNTSLGWPNGLAIDYIAGKLYWGDAKTDKIEVINVDGTNRMTILEDKLPHIFGFTLLGEYIYWTD 567

  Fly   625 WQRRSIDRAHKITGNNRIVVVDQYPDLMGLKVTRLREVRGQNACAVRNGGCSHLCLNRPRDYVCR 689
            ||||||:|.| |..:.|.|:|:|.|||||||.|::.|..|.|.||..||||||||.:||:...|.
Zfish   568 WQRRSIERVH-IANSTREVIVEQLPDLMGLKATKVMEAEGTNGCAENNGGCSHLCFHRPQGLSCA 631

  Fly   690 CAIDYELANDKRTCVVPAAFLLFSRQEHIGRISIEYNEGNHNDERIPFKDVRDAHALDVSVAERR 754
            |.:..||.:|.||||||.|||||:.:..|..||:..|.   ||..||...|::|.|||..|.|.|
Zfish   632 CPMGLELLSDLRTCVVPEAFLLFTNRADIRSISLGTNS---NDVPIPLTGVKEASALDFDVLENR 693

  Fly   755 IYWTDQKSKCIFRAFLNGSYVQRIVDSGLIGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRR 819
            |||||..:|.|.|||:|||.|:.:::.||..|:|:||||:..|:||:|....|||||||||..|:
Zfish   694 IYWTDVSTKTISRAFMNGSSVEPVIEFGLDYPEGMAVDWMGRNLYWADTGTNRIEVARLDGQYRQ 758

  Fly   820 VLLWKGVEEPRSLVLEPRRGYMYWTE-SPTDSIRRAAMDGSDLQTIVAGANHAAGLTFDQETRRL 883
            ||:.|.::.||||.|:|..||||||| .....|.||.||||::.|:|.....|.|||.|...:||
Zfish   759 VLVCKDLDNPRSLALDPANGYMYWTEWGGRPRIARAHMDGSNIVTLVDKVGRANGLTIDYIDQRL 823

  Fly   884 YWATQSRPAKIESADWDGKKRQILVGSDMDEPYAVSLYQDYVYWSDWNTGDIERVHKTTGQNRSL 948
            || |......|||.:..|.:|:| |..|:..|:.::.|:||:||:|||...|||..|.:|.||::
Zfish   824 YW-TDLDTCMIESTNMQGLQREI-VADDLPHPFGLTQYRDYIYWTDWNLRSIERADKRSGLNRTV 886

  Fly   949 VHSGMTYITSLLVFNDKRQTGVNPCKVNNGGCSHLCLAQPGRRGMTCACPTHYQLAKDGVSCIPP 1013
            |...:.|:..:|||:..||.|.|.|..|||.|:|||||.|.  |..|.|.:||.|..:|.:|..|
Zfish   887 VQGHLEYVMDILVFHSSRQDGANDCSQNNGQCAHLCLASPS--GAQCRCASHYTLEANGRNCSSP 949

  Fly  1014 RNYIIFSQRNCFGRLLPNTTDCPNIPLPVS-GKNIRAVDYDPITHHIYWIEGRSHSIKRSLANGT 1077
            .::::|||::...|::.. ...|::.||:. .||:||:.:||:...:||::|| .:|:||..:||
Zfish   950 SSFLLFSQKSSISRMVLG-EQSPDMILPIHVMKNLRAISFDPLERLVYWVDGR-QNIRRSRDDGT 1012

  Fly  1078 KVS--LLANSG---QPFDLAIDIIGRLLFWTCSQSNSINVTSFLGESVGVIDTGDSEKPRNIAVH 1137
            :.|  :..||.   ||.||::|...|.::|||..:|:||:....|..:|.:...|.:|||.|.|:
Zfish  1013 QASTVMTPNSDHPKQPHDLSLDPYSRTVYWTCETTNTINIHRMDGHIIGEVLKDDVDKPRAIVVN 1077

  Fly  1138 AMKRLLFWTDVGSHQAIIR-ARVDGNERVEL-AYKLEGVTALALDQQSDMIYY--AHGKRIDAID 1198
            |.|..:::|.|....|.|. |.:||.||..| ...|....|||||.:...:::  |..|||::.|
Zfish  1078 AEKGYMYFTTVQERSAKIEGASLDGTERESLFTTSLIRPVALALDNKLGKLFWVDADLKRIESSD 1142

  Fly  1199 INGKNKKTLVSMHISQVINIAALGGFVYWLD-DKTGVERI-TVNGERRSAELQRLPQITDIRAVW 1261
            ::|.|:..|...:|.|.:.:..||..:||:| .:..:||: .:.||:|:....||..:|.|.||.
Zfish  1143 LSGANRIVLQDSNILQPVGLTVLGDHLYWIDKQQQMIERVDKLTGEKRTRIQGRLQYLTGIHAVQ 1207

  Fly  1262 TPDPKVLRNHTCMHSRTKCSHICIASGEGIARTRDVCSCPKHLMLLEDKENCGAFPACGPDHFTC 1326
            ..:......|.|......|||||||.|:|..|    ||||.||:||::..:||..|.|..:.|||
Zfish  1208 YMETDEFATHPCSRDNGGCSHICIAKGDGTPR----CSCPMHLVLLQNLLSCGEPPTCSSEQFTC 1268

  Fly  1327 AAPVSGISDVNKDCIPASWRCDGQKDCPDKSDEVGCPTCRADQFSCQSGECIDKSLVCDGTTNCA 1391
            |.     .::  ||||.:|||||..:|.|.|||:.||.|...||.|..|:|:|..:.|:|..:||
Zfish  1269 AT-----GEI--DCIPMAWRCDGIAECADNSDEMNCPICSKLQFQCDKGQCVDIQVRCNGEPDCA 1326

  Fly  1392 NGHDEADC---CKRPGEFQCPINKLCISAALLCDGWENCADGADESSDICLQRRMA----PATDK 1449
            :|.||.||   | ...:|:|. |..||.....||.:.:|.|.:||        |..    |..|.
Zfish  1327 DGSDEQDCETIC-LSNQFRCG-NSQCILKKQQCDSFPDCTDESDE--------RFCDFPPPPNDL 1381

  Fly  1450 RAFMILIGATMITIFSI------VYLLQ--FCRTRIGKSRTEPKDDQATDP------LSPSTLSK 1500
            ......||..:..|.|:      .::.|  .||...|.:...|.:..:..|      ::|:....
Zfish  1382 PRHTSTIGPVIGIILSVFVMGGMCFVCQRVVCRHYKGPNGGFPHEYISGTPHVPLNFIAPTNSQH 1446

  Fly  1501 SQRVSKIASVADAVRMSTLNSRNSMNS----YDRNHITGASSSTTNGSSMVAYP--INPPPSPAT 1559
            .:.:|...|:     ||:::...|.:|    |||||:||||||:::.:....||  :||||||||
Zfish  1447 GKGISCGKSM-----MSSVSLMGSSSSGAPLYDRNHVTGASSSSSSSTKGAFYPQMLNPPPSPAT 1506

  Fly  1560 ----------------RSRRPYRHYKIINQPPPPTPCSTDICDESDSNYTS---KSNSNNSNGGA 1605
                            .:.|.||.|.:....||.||||||:|   ||:||:   |||.
Zfish  1507 DRSLYNAEVFYSSNSPSTTRSYRPYLMRGVAPPTTPCSTDVC---DSDYTTSRWKSNK------- 1561

  Fly  1606 TKHSSSSAAACLQYGYDSEPYPPPPTPRSHYHSDVRIVPESSCPPSPSSRSSTYFSPLPPPPSPV 1670
                     ..:....||:||||||||||.|.|     .|.|||||||:..| ||...||||||.
Zfish  1562 ---------YYMDLNSDSDPYPPPPTPRSQYMS-----AEESCPPSPSTERS-YFHLCPPPPSPC 1611

  Fly  1671 QSPS 1674
            ...|
Zfish  1612 TDSS 1615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arr	NP_524737.2	LY	162..201	CDD:214531	25/38 (66%)
		NHL	168..503	CDD:302697	169/337 (50%)
		NHL repeat	172..237	CDD:271320	41/64 (64%)
		LY	252..293	CDD:214531	17/40 (43%)
		NHL repeat	261..298	CDD:271320	18/37 (49%)
		NHL repeat	303..339	CDD:271320	17/36 (47%)
		NHL repeat	341..419	CDD:271320	31/78 (40%)
		NHL repeat	428..476	CDD:271320	21/47 (45%)
		LY	472..511	CDD:214531	28/38 (74%)
		NHL repeat	477..503	CDD:271320	20/25 (80%)
		Ldl_recept_b	534..573	CDD:278487	24/38 (63%)
		LY	558..599	CDD:214531	24/40 (60%)
		LY	600..641	CDD:214531	20/40 (50%)
		FXa_inhibition	668..703	CDD:291342	18/34 (53%)
		LY	739..773	CDD:214531	19/33 (58%)
		LY	776..818	CDD:214531	21/41 (51%)
		LY	819..860	CDD:214531	22/41 (54%)
		FXa_inhibition	973..1010	CDD:291342	18/36 (50%)
		LY	1122..1164	CDD:214531	15/42 (36%)
		FXa_inhibition	1273..1313	CDD:291342	19/39 (49%)
		LDLa	1319..1362	CDD:238060	19/42 (45%)
		LDLa	1365..1399	CDD:238060	14/33 (42%)
		LDLa	1399..1433	CDD:197566	11/36 (31%)
lrp5	XP_009296098.1	LY	105..147	CDD:214531	27/41 (66%)
		Ldl_recept_b	168..208	CDD:278487	21/41 (51%)
		LY	192..234	CDD:214531	17/41 (41%)
		LY	235..269	CDD:214531	17/33 (52%)
		FXa_inhibition	304..341	CDD:291342	20/36 (56%)
		Ldl_recept_b	390..429	CDD:278487	16/38 (42%)
		LY	413..455	CDD:214531	28/41 (68%)
		LY	456..499	CDD:214531	25/43 (58%)
		LY	501..542	CDD:214531	24/40 (60%)
		LY	544..583	CDD:214531	20/39 (51%)
		FXa_inhibition	610..645	CDD:291342	18/34 (53%)
		LY	674..714	CDD:214531	23/39 (59%)
		LY	717..757	CDD:214531	21/39 (54%)
		LY	758..800	CDD:214531	22/41 (54%)
		LY	802..843	CDD:214531	16/41 (39%)
		LY	845..884	CDD:214531	17/39 (44%)
		FXa_inhibition	911..946	CDD:291342	18/36 (50%)
		LY	974..1013	CDD:214531	16/39 (41%)
		LY	1106..1148	CDD:214531	13/41 (32%)
		FXa_inhibition	1219..1255	CDD:291342	19/39 (49%)
		LDLa	1261..1297	CDD:238060	19/42 (45%)
		LDLa	1300..1334	CDD:238060	14/33 (42%)
		LDLa	1338..1372	CDD:238060	13/43 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	119	1.000	Domainoid score	I5754
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1309	1.000	Inparanoid score	I149
OMA	1	1.010	-	-		QHG48457
OrthoDB	1	1.010	-	-		D121310at2759
OrthoFinder	1	1.000	-	-		FOG0004181
OrthoInspector	1	1.000	-	-		oto39900
orthoMCL	1	0.900	-	-		OOG6_100345
Panther	1	1.100	-	-	LDO	PTHR46513
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4876
SonicParanoid	1	1.000	-	-		X3498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870