DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and lrp2a

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:NP_001181916.1 Gene:lrp2a / 568184 ZFINID:ZDB-GENE-050119-2 Length:4673 Species:Danio rerio


Alignment Length:1865 Identity:513/1865 - (27%)
Similarity:784/1865 - (42%) Gaps:359/1865 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 LCQVIDNNEDVTTKATK-------------CTKSNSGV--GWRQMLIGFLLIC---FGISNSWQ- 61
            |.:|.||..|....|.:             |:.:|:|.  |..|...|....|   |.:||..: 
Zfish  1321 LSRVCDNTPDCPNGADESPLCNEPLPDQESCSDNNAGCTHGCIQGPFGAQCTCPMGFQLSNDSKT 1385

  Fly    62 ---YKNVHMPSSSSLIASPPASAF--------------------VNTPATLLFTTRHDIQVANI- 102
               ....|.|...|........:|                    .:..|.||..:|:.|...:| 
Zfish  1386 CEDIDECHPPGVCSQHCFNERGSFRCHCQDGYTLEADARTCKASGSREALLLVASRNQIISDDIL 1450

  Fly   103 TRPTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECAQTNSSALQPLLRAPKQTVIST 167
            .:|..   |..:|||....:|:||......:.|:|:.::.|..|..|.:        .:..:..:
Zfish  1451 AQPNA---IRSLVRDGRNIVAVDFDSVTERIYWSDTTQDRIWSAHKNGT--------DRTVIFDS 1504

  Fly   168 GLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAVAVVPARK--LLIWT 230
            |:...|.||:||....:||||.....|||:.|||.::.||...::..||.:.|.|...  |:.||
Zfish  1505 GVTVTESLAVDWVGRNLYWTDYILETIEVSKLDGSHRTVLISENVTNPRGLVVDPRNNTHLMFWT 1569

  Fly   231 DWGEYPKIERASMDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYWTDGKHHFIDVMRLDGSSRRT 295
            |||..|:||||||||.  .|.|::...::|||||.:|..|.|:|:.|....|||....||.:|:.
Zfish  1570 DWGRNPRIERASMDGK--LRTTIISNKLYWPNGLTIDYPNSLLYFADAYLDFIDYCDYDGKNRKQ 1632

  Fly   296 IVNN---LKYPFSLTFYDDRLYWTD-----------WQRGSLNALDLQTRELKELIDTPKAPNSV 346
            ::.:   |::|.::|.::|.:||||           |...:.:.:         |.:.|: |..:
Zfish  1633 VLASDLVLQHPHAITIFEDFVYWTDRYVNRVIRANKWHGQNQSVM---------LYNLPQ-PMGL 1687

  Fly   347 RAWDPSLQPYEDNPCAHNNGNCSHLCLL-ATNSQGFSCACPTGVKLISAN-TCANGSQEMMFIVQ 409
            .|..|:.||...|||..::..|:|:||| |...:.:|||||:|..|.:.. |||......:.:|:
Zfish  1688 VALHPARQPAGYNPCDPHSSPCTHICLLSAVGPRFYSCACPSGWTLAADQFTCARVEDPFLVVVR 1752

  Fly   410 RTQISKISLDSPDYTIFPL-PLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHADGTGVTDFVT 473
            .:.|..|.|:..|.:...: |:..:.....:|:|..|:.|||.: ....|.|..:|||..|:|..
Zfish  1753 DSIIYGIPLNPNDKSNDAMVPVAGLLNGYDVDFDDAEQMIYWVE-HPGEIHRVKSDGTNRTEFAP 1816

  Fly   474 SEV-RHPDGLALDWLARNLYWTDTVTDRIEVCRLDGTA--RKVLIYEH-----LEEPRAIAVAPS 530
            :.: ..|.||||||:::|||:::..:..|||.||.|..  ||.||..:     ...|..|||.|:
Zfish  1817 AAILGSPVGLALDWMSQNLYYSNPSSQAIEVLRLKGEIQYRKTLITNNGSPTGAGAPVGIAVDPA 1881

  Fly   531 LGWMFWSDWNERK---PKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVA 592
            .|.|:|:|.....   .||..|.:|||...:|.:.||.....|.:||....:||....|..||..
Zfish  1882 RGKMYWTDHGTESGIPAKVASADMDGSNAAILFTHNLEHVEFITIDITENKLYWAVTGTGVIERG 1946

  Fly   593 NMDGSGRRVVISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGLKVT 657
            :.||| .|:.:.:.|.|.:|:::...|||:||.....|:|..|.||.||:|:.|....|..|||.
Zfish  1947 DPDGS-NRITMVNGLSHPWGVAVYGSYLYFTDRDFEVIERVDKATGLNRVVMRDNVAGLRVLKVH 2010

  Fly   658 RLREVRG-QNACAVRNGGCSHLCLNRPRD-YVCRCAIDYELANDKRTCVVPAAFLLFSRQEHIGR 720
            ......| .|.|:...|.|..|||.||.. :.|.||..::|:.|.|||....::::.|....|..
Zfish  2011 HRDSSAGSSNGCSNNVGTCEQLCLPRPGGLFSCACATGFKLSADNRTCSPYQSYVVISMLTAIKG 2075

  Fly   721 ISIEYNEG-NHNDERIPFKD-VRDAHALDVSVAERRIYWTDQKSKC-----IFRAFLNGSYVQRI 778
            .|:   || :|::..:|... .|:|..:||.:|...|||.|..|..     |.|...:||..:.|
Zfish  2076 FSL---EGVDHSESMVPVAGRGRNALHVDVHMASSFIYWCDFSSTVASQNGIRRIKPDGSGFRSI 2137

  Fly   779 VDSGL--IGPDGIAVDWLANNIYWSDA--EARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRG 839
            |.||:  .|..||||||.|.|:|:::|  ....|||.||:.:.|||||...|:.||.:|::|:..
Zfish  2138 VTSGIGRNGIRGIAVDWAAGNLYFTNAFLTETYIEVIRLNTTFRRVLLKTQVDMPRHIVVDPKNR 2202

  Fly   840 YMYWTE-SPTDSIRRAAMDGSDLQTIV-AGANHAAGLTFDQETRRLYWATQSRPAKIESADWDGK 902
            |::|.: ..|..|.||.:|||:...:| :|.....||..|.....:||...|...........|:
Zfish  2203 YLFWADYGQTPKIERAFLDGSNRTALVSSGIVTPRGLALDHRDGYIYWVDDSLDMIARVRPEGGE 2267

  Fly   903 KRQILVGSDMDEPYAVSLYQDYVYWSDWNTGDIERVHKTTG--QNRSLVHSGMTYITSLLVFNDK 965
            ...:..||....||.:::::..|.|.|.|...:.|..|..|  ...:::...:..:..:.:|:.:
Zfish  2268 TEVVRYGSRYPTPYGITVFEGNVIWVDRNLKKVFRASKQPGATDQPAVIRDNINMLRDVTIFDRR 2332

  Fly   966 RQTGV------NPCKVNNGGCSHLCLAQPGRRGMTCACPTHYQLAKDGVSCIPPR-NYIIFSQRN 1023
            .|...      |||..:||||:|.|.|..|.:...|:| ....||.|..||:..| :|:|::..:
Zfish  2333 MQPSSAHELNNNPCLESNGGCAHFCFAMAGAQTRKCSC-AFGNLAADDSSCVVSRDDYLIYTTES 2396

  Fly  1024 CFGRLLPNTTDCPNIPLPVSG--KNIRAVDYDPITHHIYWIE----GRSHSIKRSLANGTK--VS 1080
            .. |.|....|..::|.||..  :...|:|:|.:...||:.:    |:|.....:||:.|.  ..
Zfish  2397 TV-RSLRLDPDDHSLPFPVVNVPRTSVALDFDRLDGRIYFTQSSGAGQSKISFITLASPTSPATE 2460

  Fly  1081 LLANSGQPFDLAIDIIGRLLFWTCSQSNSINVTSFLGESVGVIDTGDSEKPRNIAVHAMKRLLFW 1145
            :.::.|.|..:|.|.|.|.::::...:.:|:..:..|....|:  ....:||.|.:...:..::|
Zfish  2461 VASDLGAPDGIAYDWINRRIYYSDYINQTISSMAVDGSQRTVV--AQVPRPRAIMLDPCRGYMYW 2523

  Fly  1146 TDVGSHQAIIRARVDGNERVELA-YKLEGVTALALDQQSDMIYYAHG--KRIDAIDINGKNKKTL 1207
            ||.|:...|.||.:.||.|.|:. ..|.....|.||.....:|:|..  ::|:...:.|.|::.:
Zfish  2524 TDWGTSAKIERATLGGNFRTEIVNTSLVWPNGLTLDYDDQRLYWADASLQKIERCSLTGTNREVI 2588

  Fly  1208 VSMHISQVINIAALGGFVYWLDDKT-GVERITV-NGERRSAELQRLPQITDIRAVWTP-DPKVLR 1269
            ||..| ....:......:||.|..| .:.|... :|..:...||.||.        .| |..||.
Zfish  2589 VSTAI-YPFAMTVYDQHIYWTDWNTRSIYRANKHDGSDQRVMLQNLPS--------RPMDIHVLS 2644

  Fly  1270 N-------HTCMHSRTKCSHICIASGEGIARTRDVCSCP----------KHLM------------ 1305
            |       ..|......|||||....:|..     |.||          ||.:            
Zfish  2645 NSKQQQCSSPCEQFNGGCSHICTPGPQGAE-----CQCPSEGRWYLADNKHCIPDNGTRCQPGQF 2704

  Fly  1306 ------------LLEDKENCG-----------------------------AFPACGPDHFTCAAP 1329
                        ..::.::||                             ||..|.|..|||.  
Zfish  2705 TCMNGRCIRSQWKCDNDDDCGDGSDELERVCGSKHHFVFVRQAAAFISLSAFHTCEPTVFTCG-- 2767

  Fly  1330 VSGISDVNKDCIPASWRCDGQKDCPDKSDEVGC---PTCRADQFSCQSGECIDKSLVCDGTTNC- 1390
                   |..|:|..:|||...||.|.|||.||   |.....:|||.:|.||.:..:|:|..|| 
Zfish  2768 -------NGRCVPYHYRCDHYNDCGDNSDETGCIFRPCDPNTEFSCNNGRCIAREYICNGINNCY 2825

  Fly  1391 ANG-HDEADCCKR---PGEFQCPINKLCISAALLCDGWENCADGADESSDICLQRRMAPATDKRA 1451
            .|| .||.:|.:|   |...:|....:||..:.||||..:|.|.:|||...|       ||.|  
Zfish  2826 DNGTSDEQNCPERTCQPEHTKCQSTNICIPRSYLCDGDNDCGDNSDESPTHC-------ATSK-- 2881

  Fly  1452 FMILIGATMITIFSIVYLLQFC---RTRIGKSRTEPK----------DDQATDPLSPSTL----- 1498
                                 |   ..|....|..|.          :|.:.:|::.::|     
Zfish  2882 ---------------------CSHNEFRCSSGRCIPGHWYCDGGTDCNDGSDEPITCTSLVRTCN 2925

  Fly  1499 SKSQRVSKIASVADAVRMSTLNSRNSMNSYDRNHITGASSSTTNGSSMVAYPINPPPSPATRSRR 1563
            |:..|......:|.:......|....|:..|:.|  ..::.|.:.                    
Zfish  2926 SEQFRCDDGRCIASSWICDGDNDCGDMSDEDQRH--NCANRTCSA-------------------- 2968

  Fly  1564 PYRHYKIINQPPPPTPCSTD--ICD---------ESDSNYTSKSNSNNS---NGGATKHSSSSAA 1614
              :.:..:|..||...|...  :||         :...|.|.:|.|.|.   |.|          
Zfish  2969 --QEFTCVNNRPPQRKCIPRDWVCDGDADCSDAFDEHQNCTRRSCSTNEFTCNNG---------- 3021

  Fly  1615 ACLQYGYDSEPYPPPPTPRSHYHSDVRIVPESSCPPSPSSRSSTY 1659
            .|:               ||.|..|.|    :.|..|...:..||
Zfish  3022 LCI---------------RSSYRCDRR----NDCGDSSDEQGCTY 3047

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 14/38 (37%)
NHL 168..503 CDD:302697 120/354 (34%)
NHL repeat 172..237 CDD:271320 27/66 (41%)
LY 252..293 CDD:214531 16/40 (40%)
NHL repeat 261..298 CDD:271320 15/36 (42%)
NHL repeat 303..339 CDD:271320 9/46 (20%)
NHL repeat 341..419 CDD:271320 27/79 (34%)
NHL repeat 428..476 CDD:271320 14/48 (29%)
LY 472..511 CDD:214531 16/41 (39%)
NHL repeat 477..503 CDD:271320 11/25 (44%)
Ldl_recept_b 534..573 CDD:278487 13/41 (32%)
LY 558..599 CDD:214531 14/40 (35%)
LY 600..641 CDD:214531 14/40 (35%)
FXa_inhibition 668..703 CDD:291342 14/35 (40%)
LY 739..773 CDD:214531 12/39 (31%)
LY 776..818 CDD:214531 20/45 (44%)
LY 819..860 CDD:214531 17/41 (41%)
FXa_inhibition 973..1010 CDD:291342 14/36 (39%)
LY 1122..1164 CDD:214531 13/41 (32%)
FXa_inhibition 1273..1313 CDD:291342 12/73 (16%)
LDLa 1319..1362 CDD:238060 17/42 (40%)
LDLa 1365..1399 CDD:238060 14/35 (40%)
LDLa 1399..1433 CDD:197566 12/36 (33%)
lrp2aNP_001181916.1 LDLa 23..57 CDD:238060
Ldl_recept_a 61..96 CDD:278486
LDLa 103..137 CDD:238060
LDLa 143..174 CDD:238060
LDLa 178..212 CDD:238060
LDLa 217..251 CDD:238060
LDLa 258..292 CDD:238060
NHL <429..610 CDD:302697
NHL repeat 461..496 CDD:271320
LY 495..540 CDD:214531
LY 543..583 CDD:214531
NHL repeat 550..591 CDD:271320
FXa_inhibition 655..696 CDD:291342
LY 768..804 CDD:214531
Ldl_recept_b 830..870 CDD:278487
LY 854..896 CDD:214531
FXa_inhibition 973..1005 CDD:291342
LDLa 1018..1052 CDD:238060
LDLa 1059..1093 CDD:238060
LDLa 1101..1135 CDD:238060
LDLa 1141..1175 CDD:238060
LDLa 1179..1214 CDD:238060
LDLa 1222..1255 CDD:197566
LDLa 1264..1298 CDD:238060
LDLa 1304..1337 CDD:197566 6/15 (40%)
FXa_inhibition 1351..1386 CDD:291342 10/34 (29%)
EGF_CA 1388..1418 CDD:214542 4/29 (14%)
LY 1459..1498 CDD:214531 11/46 (24%)
LY 1500..1541 CDD:214531 16/40 (40%)
LY 1543..1585 CDD:214531 20/41 (49%)
LY 1589..1630 CDD:214531 16/40 (40%)
FXa_inhibition 1709..1740 CDD:291342 13/30 (43%)
NHL <1799..1978 CDD:302697 64/179 (36%)
NHL repeat 1823..1866 CDD:271320 20/42 (48%)
NHL repeat 1872..1913 CDD:271320 15/40 (38%)
Ldl_recept_b 1883..1927 CDD:278487 14/43 (33%)
LY 1912..1953 CDD:214531 14/41 (34%)
NHL repeat 1920..1946 CDD:271320 8/25 (32%)
FXa_inhibition 2022..2058 CDD:291342 14/35 (40%)
NHL <2125..2295 CDD:302697 57/169 (34%)
NHL repeat 2149..2186 CDD:271320 19/36 (53%)
LY 2182..2225 CDD:214531 18/42 (43%)
NHL repeat 2189..2226 CDD:271320 14/36 (39%)
LY 2228..2267 CDD:214531 8/38 (21%)
NHL repeat 2235..2276 CDD:271320 8/40 (20%)
FXa_inhibition 2346..2382 CDD:291342 14/36 (39%)
LY 2461..2500 CDD:214531 8/38 (21%)
Ldl_recept_b 2519..2559 CDD:278487 13/39 (33%)
LY 2545..2585 CDD:214531 8/39 (21%)
Ldl_recept_b 2603..2642 CDD:278487 12/46 (26%)
FXa_inhibition 2655..2691 CDD:291342 11/40 (28%)
LDLa 2759..2793 CDD:238060 17/42 (40%)
LDLa 2798..2835 CDD:238060 14/36 (39%)
LDLa 2838..2872 CDD:294076 11/33 (33%)
LDLa 2882..2913 CDD:238060 5/30 (17%)
LDLa 2923..2955 CDD:197566 5/31 (16%)
LDLa 2965..3002 CDD:197566 7/58 (12%)
LDLa 3011..3045 CDD:238060 12/62 (19%)
LDLa 3050..3083 CDD:238060
LDLa 3093..3127 CDD:238060
cEGF 3150..3173 CDD:289433
vWFA <3165..3206 CDD:294047
LY 3237..3279 CDD:214531
LY 3282..3321 CDD:214531
Ldl_recept_b 3350..3390 CDD:278487
LY 3376..3416 CDD:214531
LY 3417..3458 CDD:214531
FXa_inhibition 3486..>3514 CDD:291342
LDLa 3529..3561 CDD:238060
LDLa 3570..3602 CDD:238060
LDLa 3611..3643 CDD:238060
LDLa 3651..3683 CDD:197566
LDLa 3699..3731 CDD:238060
LDLa 3738..3771 CDD:238060
LDLa 3776..3810 CDD:238060
LDLa 3815..3849 CDD:238060
LDLa 3859..3891 CDD:238060
LDLa 3902..3932 CDD:197566
LDLa 3945..3979 CDD:238060
EGF_CA 4024..4055 CDD:214542
LY 4158..4193 CDD:214531
Ldl_recept_b 4214..4254 CDD:278487
LY 4238..4281 CDD:214531
FXa_inhibition 4356..>4377 CDD:291342
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170590466
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.740

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