DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and lrp1ab

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:XP_021325646.1 Gene:lrp1ab / 565797 ZFINID:ZDB-GENE-030131-7126 Length:4562 Species:Danio rerio


Alignment Length:1578 Identity:463/1578 - (29%)
Similarity:741/1578 - (46%) Gaps:230/1578 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 PSSSSLIASPPASAFVNTPATLLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNL 132
            |...|..::.|...|:      :|:.||:|:..::.:    .:..|:|..|...:|:||::.::.
Zfish  1259 PDGESCKSTDPFKPFI------IFSNRHEIRRIDLYK----GEFSVLVPGLRNTIALDFHFNQSS 1313

  Fly   133 VCWTDSGRE-IIECAQTNSSALQPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEV 196
            :.|||...: |.....:.:.||...     :.||..||..|||||:||....|||.:...::|||
Zfish  1314 LYWTDVVEDKIYRGKLSENGALTSF-----EVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEV 1373

  Fly   197 ATLDGRYQKVLFWTDLDQPRAVAVVPARKLLIWTDW-GEYPKIERASMDGDPLSRMTLVKEHVF- 259
            |.|||..:..|...:::.|||:|:.|...:|.|||| ...|:||.|||.|:  .|.|:.||... 
Zfish  1374 AKLDGTMRTTLLAGEVEHPRAIALDPRDGILFWTDWDASSPRIEAASMSGE--GRRTIHKETGIG 1436

  Fly   260 -WPNGLAVDLKNELIYWTDGKHHFIDVMRLDGSSRRTIV---NNLKYPFSLTFYDDRLYWTDWQR 320
             |||||.||.....|.|.|.:...|.....|||....::   .:|.:||::|.|...:|||||:.
Zfish  1437 GWPNGLTVDYLERRILWIDARSDAIYSAAYDGSGLIEVLRGHEHLSHPFAVTLYGGEVYWTDWRT 1501

  Fly   321 GSLNALDLQTRELKELID-TPKAPNSVRAWDPSLQPYEDNPCAHNNGN--CSHLCLLATNSQGFS 382
            .:|...:..|.....::. |...|..::.:.||.||...||||.|:|.  ||||||:..| |.||
Zfish  1502 NTLARANKWTGHNVTVVQRTNTQPFDLQVFHPSRQPQAPNPCAANDGKGPCSHLCLINYN-QTFS 1565

  Fly   383 CACPTGVKL-ISANTCANGSQEMMFIVQRTQISKISLDSPDYT-IFPLPLGKVKYAIAIDYDPVE 445
            ||||..:|| ...:||....|.::: .::.:|..:.:|:|.|. |....:..:.....:|||.:|
Zfish  1566 CACPHLMKLKADKHTCYEYRQFLLY-ARQIEIRGVDIDNPYYNYIISFTVPDIDNVTVVDYDALE 1629

  Fly   446 EHIYWSDVETYTIKRAHADGTGVTDFVTSEVRHPDGLALDWLARNLYWT--DTVTDRIEVCRLDG 508
            ..||||||.|.|||||..:||||...|::::.:..|||:||::|||:||  ||...:|.|.||||
Zfish  1630 HRIYWSDVRTQTIKRAFINGTGVETVVSADLPNAQGLAVDWISRNLFWTSYDTNKKQINVARLDG 1694

  Fly   509 TARKVLIY-EHLEEPRAIAVAPSLGWMFWSDWNERKPKVERASLDGSERVVLVSENLGWPNGIAL 572
            :.:..:|: :.|::|..:.:.|.||.::|.|.:    .:..|::||:...:|.:...| |.|:::
Zfish  1695 SFKNAVIHGQGLDKPHCLVLHPILGKLYWLDGD----NISMANMDGTNHTLLFTNQKG-PVGLSI 1754

  Fly   573 DIEAKAIYWCDGKTDKIEVANMDGSGRRVV--ISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHK 635
            |.:::.:||...:...|....|||||..|:  :...|.....|:|:.|.|:|.|.....|....|
Zfish  1755 DFDSEQLYWISSRNSTINHCKMDGSGLEVIESVKGKLTKATALAIMGDKLWWADQSTDQIGTCDK 1819

  Fly   636 ITGNNRIVVVDQYPDLMGLKV--TRLREVRGQNACAVRNGGCSHLCL-NRPRDYVCRCAIDYELA 697
            ..|.|..|:......:|.:|:  ..:.:: |.|.|:..||.||.||| ..|....|.|...|.|.
Zfish  1820 SDGGNWKVLRYHTSPMMHMKIYNESVHQI-GTNLCSKNNGDCSQLCLPTSPSTRACMCTAGYSLK 1883

  Fly   698 NDKRTCVVPAAFLLFSRQEHIGRISIEYNEGNHNDERIPFKDVRDAHALDVSVAERRIYWTDQKS 762
            :.:::|....:|||:|..|.|..|.::  ..:.:|..:|......|..:|.......|||.|...
Zfish  1884 SGQQSCEGMGSFLLYSVHEGIRGIPLD--PSDKSDALVPVSGTSLAVGIDFHADNDTIYWVDMGL 1946

  Fly   763 KCIFRAFLNGSYVQRIVDSGLIGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLWKGVE 827
            ..|.||..:.::.:.||.:|:...:||.|||:|.||||:|.....||||||:||.|.|::..|::
Zfish  1947 STISRAKRDQTWREDIVTNGIGRVEGITVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISHGLD 2011

  Fly   828 EPRSLVLEPRRGYMYWTE-SPTDSIRRAAMDGSDLQTIV-AGANHAAGLTFDQETRRLYWATQSR 890
            :||::.:.|.:||::||| .....|.|:.:|||:...:| ...:...|::.|.:...|||. .:|
Zfish  2012 KPRAIAVHPEKGYLFWTEWGQYPRIERSRLDGSERVVLVNVSISWPNGISIDYQEGLLYWC-DAR 2075

  Fly   891 PAKIESADWD-GKKRQILVGSDMDEPYAVSLYQDYVYWSDWN--TGDIERVHKTTGQNRSLVHSG 952
            ..|||..:.: |:.|::::.|:..:.:|||:::||:||||..  .|.|:|.:|....:...:.:|
Zfish  2076 TDKIERINLETGENRELVLSSNNMDMFAVSVFEDYIYWSDRTHANGSIKRGNKDNATDMVYLRTG 2140

  Fly   953 M-TYITSLLVFNDKRQTGVNPCKVNNGGCSHLCLAQPGRRGMTCACPTHYQLAKDGVSCIPPRNY 1016
            : ..:..:.|||..||.|.|.||||||||..|||.: |....|||| .|..||:||.||.....|
Zfish  2141 IGVQLKDIKVFNRARQQGTNVCKVNNGGCEQLCLFR-GNGNRTCAC-AHGMLAEDGHSCRDYDGY 2203

  Fly  1017 IIFSQRNCFGRLLPNTTDCPNIPLPVSG-------KNIRAVDYD------PITHHIYWIEGRSHS 1068
            :::|:|.....:  :.:|..|:..|:..       ||:.|:.:|      ...:.|::.:....:
Zfish  2204 LLYSERTILKSI--HLSDETNLNAPIKPFEDPEHMKNVIALTFDYRGGGGKGANRIFYSDIHFGN 2266

  Fly  1069 IKRSLANGT-KVSLLANSGQPFDLAIDIIGRLLFWTCSQSNSINVTSFLGESVGVID-------T 1125
            |:....:|: :.:::.|.|....||.......|:||...:::|...:......|..|       :
Zfish  2267 IQHINDDGSDRKTIVDNVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQSRSGAFDRDTVVTMS 2331

  Fly  1126 GDSEKPRNIAVHAMKRLLFWTDVGSHQ-AIIRARVDG-NERVELAYKLEGVTALALDQQSDMIYY 1188
            || :.||...:...:.|:|||:..... :|:||.:.| |..|.:...:.....||:|.:::.:|:
Zfish  2332 GD-DHPRAFVLDECQDLMFWTNWNEQSPSIMRASLSGANVLVIIGNNIRTPNGLAIDHRAEKLYF 2395

  Fly  1189 AHG--KRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLD---------DKTGVER------ 1236
            :..  .:|:..:.:|..:..::.........:|..|.:::|.|         ||.|.:.      
Zfish  2396 SDATFDKIERCEYDGSRRFVVLKNEPVHPFGLAVYGDYIFWTDWVRRAVLRADKYGRDMKVLRAD 2460

  Fly  1237 --------ITVNGERRSAEL----------QRLPQITD---IRAVWTPDPKVLRNHTCMHSRTKC 1280
                    |.|..:..|.|.          |.|..||.   :......:.|:|.::||:...|.|
Zfish  2461 IPQQPMGIIAVAKDTNSCEFSPCLTNNGGCQDLCLITSEGRVNCSCRGERKLLGDNTCVAENTTC 2525

  Fly  1281 SHI---------CI---ASGEGIARTRD------------VCS----------CPKHLMLLEDKE 1311
            :.:         ||   .:.:.:|..:|            :|.          |.||....:..:
Zfish  2526 NSVDEFECGNGDCIDYSLTCDSLAHCKDKSDEKQAYCANRMCKKGYRRCINGRCIKHSSWCDSTD 2590

  Fly  1312 NCG----AFPA----CGPDHFTC--------------------------AAP----------VSG 1332
            :||    ..|.    |....|.|                          .:|          |.|
Zfish  2591 DCGDGSDELPCNMTLCSAAEFQCKDGSCITNSSRCNQVVDCEDASDEMNCSPTDCSSYYLLGVKG 2655

  Fly  1333 IS----DVNKDCIPASWRCDGQKDCPDKSDEVGCP-----TCRADQFSCQSGECIDKSLVCDGTT 1388
            ::    :....|...||||||..||.|.|||..||     .|..:.|:|.||.||..|..||...
Zfish  2656 MTFERCEFTTLCFAPSWRCDGSNDCGDFSDERNCPEKRQQKCSENNFACPSGRCIPMSWTCDKEN 2720

  Fly  1389 NCANGHDEADCCK-----RPGEFQCPINKLCISAALLCDGWENCADGADE--------------- 1433
            :|.:|.|||.|.|     ...:|:|. |..||....:|||.::|.||.||               
Zfish  2721 DCEDGADEAHCEKFFQFCASNQFECG-NHRCIFKTWVCDGTDDCGDGTDEDSRCKAKTCGPDSFQ 2784

  Fly  1434 --SSDICLQRRMAPATDK 1449
              .|.:|:.:|.....||
Zfish  2785 CPGSHVCILQRWVCDGDK 2802

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 19/38 (50%)
NHL 168..503 CDD:302697 137/347 (39%)
NHL repeat 172..237 CDD:271320 28/65 (43%)
LY 252..293 CDD:214531 17/42 (40%)
NHL repeat 261..298 CDD:271320 13/39 (33%)
NHL repeat 303..339 CDD:271320 11/36 (31%)
NHL repeat 341..419 CDD:271320 31/80 (39%)
NHL repeat 428..476 CDD:271320 21/47 (45%)
LY 472..511 CDD:214531 19/40 (48%)
NHL repeat 477..503 CDD:271320 13/27 (48%)
Ldl_recept_b 534..573 CDD:278487 9/38 (24%)
LY 558..599 CDD:214531 12/40 (30%)
LY 600..641 CDD:214531 11/42 (26%)
FXa_inhibition 668..703 CDD:291342 13/35 (37%)
LY 739..773 CDD:214531 9/33 (27%)
LY 776..818 CDD:214531 22/41 (54%)
LY 819..860 CDD:214531 14/41 (34%)
FXa_inhibition 973..1010 CDD:291342 21/36 (58%)
LY 1122..1164 CDD:214531 14/50 (28%)
FXa_inhibition 1273..1313 CDD:291342 11/73 (15%)
LDLa 1319..1362 CDD:238060 19/82 (23%)
LDLa 1365..1399 CDD:238060 15/33 (45%)
LDLa 1399..1433 CDD:197566 13/38 (34%)
lrp1abXP_021325646.1 LDLa 36..69 CDD:197566
LDLa 81..114 CDD:197566
FXa_inhibition 170..198 CDD:317114
NHL <292..479 CDD:302697
NHL repeat 292..325 CDD:271320
LY 323..365 CDD:214531
NHL repeat 332..368 CDD:271320
LY 368..408 CDD:214531
NHL repeat 373..413 CDD:271320
NHL repeat 421..467 CDD:271320
FXa_inhibition 494..526 CDD:317114
LY 558..600 CDD:214531
LY 602..640 CDD:214531
LY 647..695 CDD:214531
LY <707..740 CDD:214531
FXa_inhibition 811..846 CDD:317114
LDLa 857..889 CDD:197566
LDLa 899..932 CDD:238060
LDLa 940..971 CDD:238060
LDLa 982..1015 CDD:238060
LDLa 1019..1052 CDD:238060
LDLa 1066..1101 CDD:238060
LDLa 1110..1144 CDD:238060
LDLa 1149..1185 CDD:238060
FXa_inhibition 1188..1224 CDD:317114
LY 1339..1381 CDD:214531 21/41 (51%)
LY 1383..1426 CDD:214531 18/44 (41%)
LY 1437..1470 CDD:214531 13/32 (41%)
LY 1479..1515 CDD:214531 12/35 (34%)
LY 1616..1652 CDD:214531 18/35 (51%)
LY 1653..1696 CDD:214531 19/42 (45%)
LY 1700..1739 CDD:214531 11/42 (26%)
LY 1739..1780 CDD:214531 11/41 (27%)
FXa_inhibition 1853..1889 CDD:317114 13/35 (37%)
LY 1919..1959 CDD:214531 10/39 (26%)
LY 1962..2002 CDD:214531 22/39 (56%)
LY 2003..2046 CDD:214531 15/42 (36%)
LY 2048..2090 CDD:214531 11/42 (26%)
FXa_inhibition 2162..2197 CDD:317114 21/36 (58%)
SGL 2236..2464 CDD:331563 44/228 (19%)
Ldl_recept_b 2346..2387 CDD:278487 12/40 (30%)
LY 2372..2413 CDD:214531 7/40 (18%)
FXa_inhibition 2483..2518 CDD:317114 6/34 (18%)
LDLa 2523..2559 CDD:294076 6/35 (17%)
LDLa 2567..2601 CDD:238060 6/33 (18%)
LDLa 2606..2640 CDD:238060 3/33 (9%)
LDLa <2667..2689 CDD:238060 13/21 (62%)
LDLa 2697..2731 CDD:238060 15/33 (45%)
LDLa 2738..2769 CDD:197566 11/31 (35%)
LDLa 2777..2810 CDD:197566 5/26 (19%)
LDLa 2821..2853 CDD:197566
Ldl_recept_a 2861..2895 CDD:278486
LDLa 2908..2942 CDD:238060
cEGF 2965..2988 CDD:315355
EGF_CA 2985..3019 CDD:214542
LY 3052..3096 CDD:214531
LY 3097..3139 CDD:214531
LY 3141..3183 CDD:214531
LY 3184..3226 CDD:214531
LY 3227..3267 CDD:214531
FXa_inhibition 3297..3333 CDD:317114
LDLa 3337..3368 CDD:238060
LDLa 3377..3411 CDD:238060
LDLa 3416..3451 CDD:238060
LDLa 3455..3488 CDD:197566
LDLa 3496..3529 CDD:197566
LDLa 3539..3573 CDD:238060
LDLa 3578..3612 CDD:238060
LDLa 3616..3650 CDD:238060
LDLa 3658..3690 CDD:238060
LDLa 3699..3735 CDD:238060
LDLa 3741..3776 CDD:238060
EGF_CA 3825..3855 CDD:214542
LY 3963..3999 CDD:214531
Ldl_recept_b 4020..4060 CDD:278487
LY 4044..4085 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170590468
Domainoid 1 1.000 89 1.000 Domainoid score I7812
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.640

Return to query results.
Submit another query.