DRSC/TRiP Functional Genomics Resources

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Protein Alignment arr and lrp1ba

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:XP_021325253.1 Gene:lrp1ba / 565136 ZFINID:ZDB-GENE-050208-608 Length:4654 Species:Danio rerio


Alignment Length:1633 Identity:462/1633 - (28%)
Similarity:756/1633 - (46%) Gaps:274/1633 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 EPQLCQVIDNNEDVTTKATKCTKSNSGVGWRQMLIGFLLICFGISNSWQYKNVHMPS-------- 69
            :.|.|:::    |..:|..:|::                :|      .|:||....|        
Zfish  1212 DAQTCEIL----DYCSKHLRCSQ----------------VC------EQHKNTVKCSCYPGWSLG 1250

  Fly    70 --SSSLIASPPASAFVNTPATLLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNL 132
              ..|..::.|..||:      :|:.||:|:..|:.:    ....::|..|...:|:||:::::|
Zfish  1251 SDGDSCYSTDPFEAFI------IFSIRHEIRRINLHK----GDYSLLVPGLRNTIALDFHFSQSL 1305

  Fly   133 VCWTDSGREIIECAQTNS----SALQPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNR 193
            :.|||...:.|...:.:.    ||:        :.|:..||..|||||:||....:||.|...::
Zfish  1306 LYWTDVVEDKIYRGKLSEGGGVSAI--------EVVVQHGLATPEGLAVDWIAGNLYWIDSNLDQ 1362

  Fly   194 IEVATLDGRYQKVLFWTDLDQPRAVAVVPARKLLIWTDW-GEYPKIERASMDGDPLSRMTLVKEH 257
            |||:.|:|..:..|....::.|||:||.|.:..|.|||| ..:|:||.|||.|.        :.|
Zfish  1363 IEVSKLNGELRTTLIAGGMEHPRAIAVDPGQGALFWTDWDATFPRIEGASMSGK--------QRH 1419

  Fly   258 VF--------WPNGLAVDLKNELIYWTDGKHHFIDVMRLDGSSRRTIVNN---LKYPFSLTFYDD 311
            |.        |||||.:|.....|.|||.:...|.....||:....|:..   |.:||:::.:..
Zfish  1420 VVFKDMDTGAWPNGLTLDHMESRIIWTDARSDAIYSALYDGTGVIEILRGHEFLSHPFAVSLFGG 1484

  Fly   312 RLYWTDWQRGSLNALDLQTRELKELID-TPKAPNSVRAWDPSLQPYEDNPCAHN--NGNCSHLCL 373
            .:|||||:..:|...:..|.....:|. |...|..:..:.||.||...:|||.|  .|:||||||
Zfish  1485 NVYWTDWRTNTLTKANKWTGANVTVIQKTSAQPFDLEIYHPSRQPQTVSPCAGNGGRGHCSHLCL 1549

  Fly   374 LATNSQGFSCACPTGVKLISANTCANGSQEMMFIVQRTQISKISLDSPDY--TIFPLPLGKVKYA 436
            |..|... ||:||..:||.:.|:...|.:..:...:|::|..:.:|:| |  .|..|.:..:...
Zfish  1550 LNYNGSA-SCSCPHLMKLSANNSTCQGVKRFLLYARRSEIRGVDIDNP-YLNVIMALTVPDIDDV 1612

  Fly   437 IAIDYDPVEEHIYWSDVETYTIKRAHADGTGVTDFVTSEVRHPDGLALDWLARNLYWTDTVTD-- 499
            .::|||.|||.|||:||::.|||||..:||.:...::.::.:..|||:|||:||:||..:..|  
Zfish  1613 TSMDYDAVEERIYWADVKSRTIKRAFINGTQLQTVLSGDLSNVRGLAIDWLSRNMYWMSSDNDET 1677

  Fly   500 RIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERKPKVERASLDGSERVVLVSENL 564
            .|.|.||||:.:..::: .:::|:::.:.||.|.|||.|..    .:..|::||| .:.::.:|.
Zfish  1678 HINVARLDGSLKTTVVH-GMDKPKSLVLHPSKGKMFWMDGG----TINMANMDGS-NIKILHQNQ 1736

  Fly   565 GWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVV--ISDNLKHLFGLSILDDYLYWTDWQR 627
            ..|.|:::|..:..:||.......|...|:||||..|:  :...|:....|:::...|:|.|...
Zfish  1737 KEPVGLSIDFSSNKLYWISSGNGTINRCNLDGSGLDVIDSMKSQLRKATALAVMGGKLWWADDVL 1801

  Fly   628 RSIDRAHKITGNNRIVVVDQYPDLMGLKVTRLREVRGQNACAVRNGGCSHLCLNRPRDYV---CR 689
            ..:...:|..|.|..|:.::...|:.:||......:|:|.|.:.|||||.:||  |...:   |.
Zfish  1802 AQLGTVNKRDGKNLTVLRNKTTGLVHIKVYDKDTQKGRNPCVLNNGGCSQICL--PTSEITRTCS 1864

  Fly   690 CAIDYELANDKRTCVVPAAFLLFSRQEHIGRISIEYNEGNHNDERI-PFKDVRDAHALDVSVAER 753
            |...|.|..|:.||....:||::|..|.|..:|::.::   |.|.: |......|..||......
Zfish  1865 CTTGYNLRQDRSTCEGLQSFLMYSVNEGIRGLSLDPSD---NSEVLTPLSGTLFAVGLDYHAKND 1926

  Fly   754 RIYWTDQKSKCIFRAFLNGSYVQRIVDSGLIGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSR 818
            .:||||..|..|.|:..:.::.:.|:.|||...:|:||||:|.||||:|.....||||||:|..|
Zfish  1927 TLYWTDMGSNKISRSSRDQTWREDIITSGLGRVEGLAVDWIAGNIYWADHGLNLIEVARLNGMYR 1991

  Fly   819 RVLLWKGVEEPRSLVLEPRRGYMYWTE---SPTDSIRRAAMDGSDLQTIVA-GANHAAGLTFDQE 879
            .|::.:.:::||::.:.|.:|:::|||   |||  |.|:.:|||:...:|: |.....|::.|.:
Zfish  1992 AVVISEELDQPRAIAVHPVKGFLFWTEWGQSPT--ISRSRLDGSEQSVLVSTGLARPNGVSIDYQ 2054

  Fly   880 TRRLYWATQSRPAKIESADWD-GKKRQILVGSDMDEPYAVSLYQDYVYWSD--WNTGDIERVHKT 941
            ..:|||. .:|..|||..:.: |::|:|:..|...:.::::::..|::|||  :..|.|.|..|.
Zfish  2055 ENKLYWC-DARNNKIERINLERGEQREIVFSSSGVDMFSIAVFGAYLFWSDRAYANGSIRRASKK 2118

  Fly   942 TGQNRSLVHSGMTY-ITSLLVFNDKRQTGVNPCKVNNGGCSHLCLAQPGRRGMTCACPTHYQLAK 1005
            ...:...:.||::. :..:.|||..|:.|.|.|..:||||..||. ..|....|||| .|..||:
Zfish  2119 DAVDVVTIRSGLSVSLKDVKVFNQDREKGTNACSKSNGGCQQLCF-YLGNNRKTCAC-AHGYLAQ 2181

  Fly  1006 DGVSCIPPRNYIIFSQRNCFGRLLPNTTDCPNIPL-----PVSGKNIRAVDYDPI-----THHIY 1060
            ||:.||....|:::|:|.....:..:..:..|.|:     ||..|||.|:.:|..     |:.|:
Zfish  2182 DGLRCIRYEGYLLYSERTVLRTIHLSDENDLNSPIRAYENPVYFKNIIALAFDHRQNAHGTNRIF 2246

  Fly  1061 WIEGRSHSIKRSLANGTKVSLLA-NSGQPFDLAIDIIGRLLFWTCSQSNSI--------NVTSFL 1116
            :.:....:|:....:.|...::| |.|....||......:|:||.|.:.||        ...:|.
Zfish  2247 FSDVHYGNIQVINDDWTGRRIIAENVGSVEGLAYHRGWDVLYWTSSTTASITRHHIDQSRTNAFD 2311

  Fly  1117 GESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVG-SHQAIIRARVDG-NERVELAYKLEGVTALAL 1179
            .::  |:...:.:.|..:.:...:.|:|||:.. .|.:|:|:.:.| |.|:.::..:.....|.:
Zfish  2312 RDT--VVSLSEEDHPHVLTLDECQNLMFWTNWNEQHPSIMRSTLTGRNIRIIVSTDVITPNGLTI 2374

  Fly  1180 DQQSDMIYYAHGK--RIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLD---------DK-T 1232
            |.:::.:|::.|.  .|:..|.:|..:..:|.........:|....|::|.|         || |
Zfish  2375 DHKAEKLYFSDGSLGHIERCDFDGSQRYVIVKSGPGTFFGLAIYRDFIFWSDWTRRAVIRSDKFT 2439

  Fly  1233 GVER--------------ITVNGERRSAE----------LQRLPQITDI----------RAVWTP 1263
            |...              |.|:.:..|.|          ...|..:|.:          |.:...
Zfish  2440 GANTKVLRSDIPHQPMGIIAVSNDTNSCEASPCSVNNGGCHDLCLLTPLGVVNCSCRGERILLDD 2504

  Fly  1264 DPKVLRNHTC-MHSRTKCSH-ICI---ASGEGIARTRD-------VCS---------------CP 1301
            :..|..|.:| :||..:|.: .||   .:.:|||..:|       .|.               |.
Zfish  2505 NRCVSPNSSCNIHSEFQCGNGECIDYQLTCDGIAHCKDRSDEKMQYCENRNCRHGFKSCYNQRCV 2569

  Fly  1302 KHLMLLEDKENCG--------------------AFPACGPDHFTC-----AAPVSGISDVNKD-- 1339
            .:........:||                    |..:|.|....|     .|..|.....|..  
Zfish  2570 SNQRFCNGVNDCGDNSDEVYCNNSSCLSSEHRCADGSCIPTSSWCNQIIDCADASDEKSCNNTDC 2634

  Fly  1340 ------------------------CIPASWRCDGQKDCPDKSDEVGC-----PTCRADQFSCQSG 1375
                                    |:..||.|||..||.|.:||..|     .||....|:|.||
Zfish  2635 MGYYRLGARASNTERFLSCNSTSLCVHPSWICDGANDCGDYADETHCHASAVHTCEDGHFACPSG 2699

  Fly  1376 ECIDKSLVCDGTTNCANGHDEADC---CKRPGEFQCPINKLCISAALLCDGWENCADGADESSDI 1437
            .||....:|||..:|.:|.||..|   |.. .:|.|..|| |||...||||.::|.||.|||.:|
Zfish  2700 NCISSVWLCDGQKDCEDGADEFQCDSSCLW-NQFACSKNK-CISKQWLCDGEDDCGDGLDESQEI 2762

  Fly  1438 CLQRRMAP 1445
            |.....:|
Zfish  2763 CGSASCSP 2770

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 17/38 (45%)
NHL 168..503 CDD:302697 127/353 (36%)
NHL repeat 172..237 CDD:271320 27/65 (42%)
LY 252..293 CDD:214531 15/48 (31%)
NHL repeat 261..298 CDD:271320 13/36 (36%)
NHL repeat 303..339 CDD:271320 10/36 (28%)
NHL repeat 341..419 CDD:271320 28/79 (35%)
NHL repeat 428..476 CDD:271320 19/47 (40%)
LY 472..511 CDD:214531 17/40 (43%)
NHL repeat 477..503 CDD:271320 12/27 (44%)
Ldl_recept_b 534..573 CDD:278487 11/38 (29%)
LY 558..599 CDD:214531 11/40 (28%)
LY 600..641 CDD:214531 8/42 (19%)
FXa_inhibition 668..703 CDD:291342 14/37 (38%)
LY 739..773 CDD:214531 10/33 (30%)
LY 776..818 CDD:214531 22/41 (54%)
LY 819..860 CDD:214531 15/43 (35%)
FXa_inhibition 973..1010 CDD:291342 17/36 (47%)
LY 1122..1164 CDD:214531 11/43 (26%)
FXa_inhibition 1273..1313 CDD:291342 12/66 (18%)
LDLa 1319..1362 CDD:238060 17/73 (23%)
LDLa 1365..1399 CDD:238060 14/33 (42%)
LDLa 1399..1433 CDD:197566 16/36 (44%)
lrp1baXP_021325253.1 LDLa 30..62 CDD:197566
LDLa 74..107 CDD:197566
FXa_inhibition 163..191 CDD:317114
LY 276..309 CDD:214531
LY 317..359 CDD:214531
LY 362..402 CDD:214531
FXa_inhibition 487..519 CDD:317114
LY 553..593 CDD:214531
LY 594..633 CDD:214531
LY 640..689 CDD:214531
LY 690..732 CDD:214531
FXa_inhibition 801..838 CDD:317114
LDLa 891..924 CDD:238060
LDLa 974..1007 CDD:238060
LDLa 1011..1042 CDD:197566
LDLa 1057..1092 CDD:238060
LDLa 1104..1135 CDD:238060
LDLa 1140..1173 CDD:197566
FXa_inhibition 1180..1216 CDD:317114 1/3 (33%)
LY 1284..1322 CDD:214531 10/37 (27%)
LY 1331..1370 CDD:214531 17/38 (45%)
LY 1375..1418 CDD:214531 19/50 (38%)
LY <1430..1463 CDD:214531 13/32 (41%)
LY 1604..1643 CDD:214531 18/38 (47%)
LY 1645..1687 CDD:214531 16/41 (39%)
LY 1689..1728 CDD:214531 12/44 (27%)
LY <1739..1770 CDD:214531 9/30 (30%)
FXa_inhibition 1842..1878 CDD:317114 14/37 (38%)
NHL 1923..>2095 CDD:302697 61/174 (35%)
NHL repeat 1923..1956 CDD:271320 9/32 (28%)
NHL repeat 1961..1996 CDD:271320 20/34 (59%)
NHL repeat 2002..2040 CDD:271320 15/39 (38%)
NHL repeat 2043..2084 CDD:271320 12/41 (29%)
FXa_inhibition 2151..2186 CDD:317114 17/36 (47%)
LY 2265..2305 CDD:214531 11/39 (28%)
Ldl_recept_b 2334..2375 CDD:278487 11/40 (28%)
LY 2359..2401 CDD:214531 8/41 (20%)
FXa_inhibition 2472..2506 CDD:317114 3/33 (9%)
LDLa 2518..2547 CDD:238060 8/28 (29%)
LDLa 2556..2590 CDD:238060 3/33 (9%)
LDLa 2595..2629 CDD:238060 6/33 (18%)
LDLa <2652..2681 CDD:294076 11/28 (39%)
LDLa 2689..2723 CDD:238060 14/33 (42%)
LDLa 2727..2758 CDD:238060 15/32 (47%)
LDLa 2768..2801 CDD:238060 1/3 (33%)
LDLa 2811..2843 CDD:197566
LDLa 2852..2884 CDD:197566
LDLa 2898..2932 CDD:238060
cEGF 2955..2978 CDD:315355
EGF_CA 2975..3005 CDD:214542
LY 3042..3086 CDD:214531
LY 3088..3125 CDD:214531
Ldl_recept_b 3149..3189 CDD:278487
LY 3173..3213 CDD:214531
FXa_inhibition 3284..3320 CDD:317114
LDLa 3324..3355 CDD:197566
LDLa 3364..3398 CDD:238060
LDLa 3403..3438 CDD:238060
LDLa 3443..3478 CDD:238060
LDLa 3483..3517 CDD:238060
LDLa 3522..3556 CDD:238060
LDLa 3560..3594 CDD:238060
LDLa 3608..3642 CDD:238060
LDLa 3646..3681 CDD:238060
LDLa 3688..3720 CDD:238060
LDLa 3729..3765 CDD:238060
LDLa 3775..3809 CDD:238060
Ldl_recept_b 4051..4091 CDD:278487
LY 4075..4116 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 89 1.000 Domainoid score I7812
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.810

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