DRSC/TRiP Functional Genomics Resources

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Protein Alignment arr and lrp1aa

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:XP_021335354.1 Gene:lrp1aa / 563149 ZFINID:ZDB-GENE-030131-7889 Length:4560 Species:Danio rerio


Alignment Length:1590 Identity:461/1590 - (28%)
Similarity:740/1590 - (46%) Gaps:218/1590 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 CQVIDNNEDVTTKATKCTKSNSGVGWRQMLIGFLLICFGISNSWQYKNVHMPSSSSLIASPPASA 81
            ||:    :....|..||::.     ..|........|:   ..|..:    |...|..::.|...
Zfish  1226 CQI----QGFCAKHLKCSQR-----CEQDKFNVKCSCY---EGWALE----PDMESCRSTDPFKP 1274

  Fly    82 FVNTPATLLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDSGRE-IIEC 145
            |:      :|:.||:|:..::.:    .:..|:|..|...:|:||:..::.:.|||...: |...
Zfish  1275 FI------IFSNRHEIRRIDLHK----GEFSVLVPGLRNTIALDFHLNESSLYWTDVVEDKIYRG 1329

  Fly   146 AQTNSSALQPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWT 210
            ..:.:.||...     ..||..||..|||||:||....|||.:...::||||.|||..:..|...
Zfish  1330 KLSENGALTSF-----DVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTMRTTLLAG 1389

  Fly   211 DLDQPRAVAVVPARKLLIWTDW-GEYPKIERASMDGDPLSRMTLVKE--HVFWPNGLAVDLKNEL 272
            |::.|||:|:.|...:|.|||| ...|:||.|||.|.  .|.|:.||  ...|||||.||.....
Zfish  1390 DVEHPRAIALDPREGILFWTDWDASMPRIEAASMSGH--GRRTIHKETGSGGWPNGLTVDYLERR 1452

  Fly   273 IYWTDGKHHFIDVMRLDGSSRRTIVNN---LKYPFSLTFYDDRLYWTDWQRGSLNALDLQTRELK 334
            |.|.|.:...|...:.|||....::..   |.:||::|.|...:|||||:..:|...:..|....
Zfish  1453 ILWIDARSDAIYSAKYDGSGLIEVLRGHEYLSHPFAVTMYGGEVYWTDWRTNTLAKANKWTGNNV 1517

  Fly   335 ELID-TPKAPNSVRAWDPSLQPYEDNPCAHNN--GNCSHLCLLATNSQGFSCACPTGVKLISANT 396
            .::. |...|..::.:.||.||...||||...  |.||||||:..| |.||||||..::|...|.
Zfish  1518 TVVQRTNTQPFDLQVYHPSRQPQAPNPCAARGGLGPCSHLCLINYN-QTFSCACPHLMRLREDNH 1581

  Fly   397 CANGSQEMMFIVQRTQISKISLDSPDYT-IFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKR 460
            ....|::.:...::.:|..:.:.:|.|. |....:..:.....:|||.:|..||||||.|.||||
Zfish  1582 TCYESRQFLLYARQIEIRGVDIHNPYYNYIISFTVPDIDNVTVVDYDALERRIYWSDVRTQTIKR 1646

  Fly   461 AHADGTGVTDFVTSEVRHPDGLALDWLARNLYWT--DTVTDRIEVCRLDGTARKVLIYEHLEEPR 523
            |..:|||:...|::::.:..|||:||::|||:||  |....:|.|.||||:.:..:| :.|::|.
Zfish  1647 AFINGTGIETVVSADIPNAHGLAVDWVSRNLFWTSYDGNKKQINVARLDGSFKNAVI-QGLDKPH 1710

  Fly   524 AIAVAPSLGWMFWSDWNERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDK 588
            .:.:.|.||.::|:|.:    .:..|:.||:.:.::.: |...|.|:::|.:|:.:||.......
Zfish  1711 CLVLHPVLGKLYWTDGD----NISMANTDGTNQTMIFT-NQKTPVGLSIDFDAEHLYWVSSGNST 1770

  Fly   589 IEVANMDGSGRRVV--ISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDL 651
            |....:||||..|:  :...|.....|:|:.|.|:|.|.....|....|..|.|..|:.:....:
Zfish  1771 INRCKLDGSGLEVLDSVKGKLNKASALAIMGDKLWWADQGTDQIGTCDKSDGGNWKVLRNSTSGM 1835

  Fly   652 MGLKVTRLREVRGQNACAVRNGGCSHLCL-NRPRDYVCRCAIDYELANDKRTCVVPAAFLLFSRQ 715
            :.:|:.......|.|.|:..||.||.||| .......|.|...|.|.:.:::|....:|||:|..
Zfish  1836 IHMKIYNETVQTGSNLCSKNNGDCSQLCLPTSQSSRSCMCTAGYSLRSGQQSCEGVGSFLLYSVH 1900

  Fly   716 EHIGRISIEYNEGNHNDERIPFKDVRDAHALDVSVAERRIYWTDQKSKCIFRAFLNGSYVQRIVD 780
            |.|..|.::  ..:.:|..:|......|..:|.......|||.|.....|.||..:.::.:.|:.
Zfish  1901 EGIRGIPLD--PADKSDALVPVSGTSLAVGIDFHADNDTIYWVDMGLSTISRAKRDQTWREDIIT 1963

  Fly   781 SGLIGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTE 845
            :|:...:||||||:|.||||:|.....||||||:||.|.|::.:|:::||::.:.|.|||::|||
Zfish  1964 NGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPERGYLFWTE 2028

  Fly   846 -SPTDSIRRAAMDGSDLQTIV-AGANHAAGLTFDQETRRLYWATQSRPAKIESADWD-GKKRQIL 907
             .....|.|:.:|||....:| ...:...|::.|.:...|||. .:|..|||..:.: |:.|:::
Zfish  2029 WGQYPRIERSRLDGSGRAVLVNVSISWPNGISIDYQDGLLYWC-DARTDKIERINLETGENREVV 2092

  Fly   908 VGSDMDEPYAVSLYQDYVYWSDWN--TGDIERVHKTTGQNRSLVHSGM-TYITSLLVFNDKRQTG 969
            :.|:..:.::||::::|:||||..  .|.|:|..|........:.:|: ..:..:.|||..||.|
Zfish  2093 LSSNNMDMFSVSVFENYIYWSDRTHANGSIKRGSKDNSTESVSLRTGIGVQLKDIKVFNRARQQG 2157

  Fly   970 VNPCKVNNGGCSHLCLAQPGRRGMTCACPTHYQLAKDGVSCIPPRNYIIFSQRNCFGRLLPNTTD 1034
            .|.||:|||||..|||.: |....|||| .|..||:||.||.....|:::|:|.....:..:..:
Zfish  2158 TNICKINNGGCQQLCLYR-GNGQRTCAC-AHGMLAEDGQSCRDYDGYLLYSERTILKSVHLSDEN 2220

  Fly  1035 CPNIPL-----PVSGKNIRAVDYD------PITHHIYWIEGRSHSIKRSLANGT-KVSLLANSGQ 1087
            ..|.|:     |...||:.|:.:|      ...:.|::.:....:|::...:|: :.:::.|.|.
Zfish  2221 NLNAPIKPFEDPEHMKNVIALTFDYRGGGGKGANRIFYSDIHFGNIQQINDDGSDRKTVVENVGS 2285

  Fly  1088 PFDLAIDIIGRLLFWTCSQSNSINVTSFLGESVGVID-------TGDSEKPRNIAVHAMKRLLFW 1145
            ...||.......|:||...:::|:..:......|..|       :|| :.||...:...:.|:||
Zfish  2286 VEGLAYHRAWDTLYWTSYTTSTISRHTVDQSRWGAFDRDTVVTMSGD-DHPRAFVLDECQNLMFW 2349

  Fly  1146 TDVGSHQ-AIIRARVDG-NERVELAYKLEGVTALALDQQSDMIYYAHG--KRIDAIDINGKNKKT 1206
            |:..... :|:||::.| |..|.:..::.....||:|.:::.:|::..  .:|:..:.:|.::..
Zfish  2350 TNWNEQSPSIMRAQLSGSNVIVIIGSEIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGTHRYV 2414

  Fly  1207 LVSMHISQVINIAALGGFVYWLD---------DK-TGVER--------------ITVNGERRSAE 1247
            ::.........:|..|..::|.|         || .|.|.              :.|..:..|.|
Zfish  2415 VLKNEPVHPFGLAVYGDHIFWTDWVRRAVLRADKYVGGEMKVLRADIPQQPMGIVAVANDTNSCE 2479

  Fly  1248 L----------QRLPQITD---IRAVWTPDPKVLRNHTCMHSRTKCSHI---------CI---AS 1287
            .          |.|..:|.   :......:.|:|.::||:...|.||.:         ||   .:
Zfish  2480 FSPCRVNNGGCQDLCLLTSDGRVNCSCRGERKLLEDNTCIAQNTSCSSMEDFECGNGDCIKYTLT 2544

  Fly  1288 GEGIARTRD------------VCS----------CPKHLMLLEDKENCG--------AFPACGPD 1322
            .:|:|..:|            ||.          |..|......:::||        ....|..|
Zfish  2545 CDGMAHCKDKSDEKQSYCTNRVCKKGYKRCVNGRCVGHNSWCNGRDDCGDNSDELFCNATLCTAD 2609

  Fly  1323 HFTC--AAPVSGISDVNK--DCIPA------------------------------------SWRC 1347
            .|.|  ...||..|..|:  ||..|                                    ||.|
Zfish  2610 QFQCRDGVCVSNSSRCNQVLDCDDASDEMNCSASDCSSYFRLGVKGVTYQRCEFTSLCYAPSWVC 2674

  Fly  1348 DGQKDCPDKSDEVGCP-----TCRADQFSCQSGECIDKSLVCDGTTNCANGHDEADCCK--RPGE 1405
            ||..||.|.|||..||     .|.::.|:|.:|.||..|..||...:|.||.|||.|.|  ...:
Zfish  2675 DGANDCGDYSDERNCPDKKKRKCSSNFFACPNGRCIPMSWTCDKENDCDNGDDEAHCDKFCSATQ 2739

  Fly  1406 FQCPINKLCISAALLCDGWENCADGADESS 1435
            |:|. |..|||::.:|||.::|.||.||.|
Zfish  2740 FECG-NHRCISSSWVCDGADDCGDGTDEDS 2768

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 19/38 (50%)
NHL 168..503 CDD:302697 132/346 (38%)
NHL repeat 172..237 CDD:271320 29/65 (45%)
LY 252..293 CDD:214531 17/42 (40%)
NHL repeat 261..298 CDD:271320 13/36 (36%)
NHL repeat 303..339 CDD:271320 11/36 (31%)
NHL repeat 341..419 CDD:271320 28/79 (35%)
NHL repeat 428..476 CDD:271320 20/47 (43%)
LY 472..511 CDD:214531 18/40 (45%)
NHL repeat 477..503 CDD:271320 12/27 (44%)
Ldl_recept_b 534..573 CDD:278487 8/38 (21%)
LY 558..599 CDD:214531 11/40 (28%)
LY 600..641 CDD:214531 11/42 (26%)
FXa_inhibition 668..703 CDD:291342 12/35 (34%)
LY 739..773 CDD:214531 9/33 (27%)
LY 776..818 CDD:214531 22/41 (54%)
LY 819..860 CDD:214531 15/41 (37%)
FXa_inhibition 973..1010 CDD:291342 20/36 (56%)
LY 1122..1164 CDD:214531 14/50 (28%)
FXa_inhibition 1273..1313 CDD:291342 13/73 (18%)
LDLa 1319..1362 CDD:238060 22/82 (27%)
LDLa 1365..1399 CDD:238060 15/33 (45%)
LDLa 1399..1433 CDD:197566 14/35 (40%)
lrp1aaXP_021335354.1 LDLa 37..70 CDD:197566
LDLa 82..115 CDD:197566
FXa_inhibition 171..199 CDD:317114
LY 281..324 CDD:214531
LY 326..368 CDD:214531
LY 371..411 CDD:214531
FXa_inhibition 497..529 CDD:317114
LY 561..603 CDD:214531
LY 605..643 CDD:214531
LY 650..699 CDD:214531
LY <710..743 CDD:214531
FXa_inhibition 812..848 CDD:317114
LDLa 859..891 CDD:197566
LDLa 901..934 CDD:238060
LDLa 941..973 CDD:197566
LDLa 984..1017 CDD:238060
LDLa 1021..1052 CDD:197566
LDLa 1068..1103 CDD:238060
LDLa 1112..1146 CDD:238060
LDLa 1151..1187 CDD:238060
FXa_inhibition 1190..1226 CDD:317114 461/1590 (29%)
LY 1342..1383 CDD:214531 21/40 (53%)
LY 1385..1428 CDD:214531 19/44 (43%)
LY 1429..1472 CDD:214531 16/42 (38%)
LY 1618..1653 CDD:214531 17/34 (50%)
LY 1655..1698 CDD:214531 18/42 (43%)
LY 1702..1738 CDD:214531 11/40 (28%)
LY <1749..1780 CDD:214531 9/30 (30%)
FXa_inhibition 1852..1888 CDD:317114 12/35 (34%)
LY 1918..1958 CDD:214531 10/39 (26%)
LY 1961..2001 CDD:214531 22/39 (56%)
LY 2002..2045 CDD:214531 16/42 (38%)
LY 2047..2089 CDD:214531 11/42 (26%)
FXa_inhibition 2161..2196 CDD:317114 20/36 (56%)
SGL 2235..>2439 CDD:331563 41/204 (20%)
Ldl_recept_b 2345..2386 CDD:278487 12/40 (30%)
LY 2371..2412 CDD:214531 7/40 (18%)
FXa_inhibition 2483..2518 CDD:317114 5/34 (15%)
LDLa 2530..2559 CDD:294076 5/28 (18%)
LDLa 2567..2601 CDD:238060 5/33 (15%)
LDLa 2606..2640 CDD:238060 11/33 (33%)
LDLa <2667..2689 CDD:238060 11/21 (52%)
LDLa 2697..2731 CDD:238060 15/33 (45%)
LDLa 2735..2767 CDD:238060 13/32 (41%)
LDLa 2774..2807 CDD:197566
LDLa 2818..2850 CDD:197566
LDLa 2859..2891 CDD:197566
LDLa 2906..2940 CDD:238060
cEGF 2963..2986 CDD:315355
EGF_CA 2983..3013 CDD:214542
LY 3050..3094 CDD:214531
LY 3095..3137 CDD:214531
LY 3139..3181 CDD:214531
LY 3183..3224 CDD:214531
LY 3225..3265 CDD:214531
FXa_inhibition 3295..3331 CDD:317114
LDLa 3335..3366 CDD:238060
LDLa 3375..3409 CDD:238060
LDLa 3414..3449 CDD:238060
LDLa 3453..3486 CDD:197566
LDLa 3494..3527 CDD:197566
LDLa 3537..3571 CDD:238060
LDLa 3576..3610 CDD:238060
LDLa 3614..3648 CDD:238060
LDLa 3656..3688 CDD:238060
LDLa 3697..3733 CDD:238060
LDLa 3741..3776 CDD:238060
LY 3957..3993 CDD:214531
Ldl_recept_b 4014..4054 CDD:278487
LY 4038..4079 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170590467
Domainoid 1 1.000 89 1.000 Domainoid score I7812
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.740

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