DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment arr and lrp10

DIOPT Version :9

Sequence 1:	NP_524737.2	Gene:	arr / 44279	FlyBaseID:	FBgn0000119	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	XP_688859.4	Gene:	lrp10 / 560361	ZFINID:	ZDB-GENE-140418-2	Length:	748	Species:	Danio rerio

Alignment Length:	890	Identity:	175/890 - (19%)
Similarity:	263/890 - (29%)	Gaps:	328/890 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   947 SLVHS----GMTYI----TSLLVFN-----------DKRQTGVN-------PCKVNNGGCSHLCL 985
            |::||    |:.::    |..|||:           ..||..::       |....|  ||.|..
Zfish     2 SVLHSLCFLGLLFLTVPCTLKLVFSAALCDHSPKILQSRQGEIHNSPYHSWPYHTLN--CSWLIT 64

  Fly   986 AQPGRRGMTCACPTHYQLAKDGVSCIPPRNYIIFSQRNCFGRLLPNTTDCPNIPLPVSGKNIRAV 1050
            ::.|.|.:......:.:..:..||.:|    :..|.....|..||       .|..::|.||
Zfish    65 SKVGERVIISFSQFNMRCGRQWVSVVP----LTGSPFKLCGSQLP-------APFEMTGGNI--- 115

  Fly  1051 DYDPITHHIYWIEGRSHSIKRSLANGTKVSLLANSGQPFDLAIDIIGRLLF---WTCSQ------ 1106
               .:|||..     .|...   ..|.::|...:||..|....:.......   |.|:.
Zfish   116 ---TVTHHFI-----PHIFP---VTGFRLSYFKDSGPCFPGEFECYSERCLPASWRCNGRVECLG 169

  Fly  1107 -------------------SNSIN---------------------------------------VT 1113
                               .||:|                                       :.
Zfish   170 VGDELGSDEDGCYSPEPPIDNSLNDLPPFETTTSTISLLSTDAPPPKIPDFPLLPQGGPCGGYLK 234

  Fly  1114 SFLGESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQAIIRARVDGNERVELAYKLE----GV 1174
            :|.|.....:.||            .|....||            ||..:...|..:|:    ||
Zfish   235 AFYGSFTPPVPTG------------QKMECVWT------------VDPQDSRPLKLELQQLDLGV 275

  Fly  1175 TAL--ALDQQSDMIYYAHGKRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLDDKTGVERI 1237
            ..|  ..||.     |..|..|..|.....||...|                    :.:||:
Zfish   276 KDLITITDQP-----YGMGNIIKTITFVSNNKAVEV--------------------ESRTGL--- 312

  Fly  1238 TVNGERRSAELQRLPQITDIRAVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIARTRDVCSCPK 1302
                               :..::..:|                   :..|.|...|..:..
Zfish   313 -------------------LSLIYRREP-------------------VLEGRGFNATYRITD--- 336

  Fly  1303 HLMLLEDKENCGAFPACGPDHFTCAAPVSGISDVNKDCIPASWRCDGQKDCPDKS-DEVGCPTCR 1366
                           .|.|....|...:.|       |..|..||||..|||:.. ||..|..|:
Zfish   337 ---------------YCLPWEELCGGSLGG-------CYTADQRCDGHWDCPETGLDEEACWGCK 379

  Fly  1367 ADQFSCQSG------------ECIDKSLVCDGTTNCANGHDEADC--CKRPGEFQCPINKLCISA 1417
            |..|.|..|            .|......|:...||.:|.||.:|  | :||.|.|..:: |:..
Zfish   380 AGSFLCAMGGIKKAGHQTENPVCYSFHERCNYQLNCPDGTDERECTIC-QPGTFHCDSDR-CVFE 442

  Fly  1418 ALLCDGWENCADGADE-SSDICLQRRMAPATDKRAFMILIGATMITIFSIVYLLQFCRTR----- 1476
            :..|||..:|.||.|| :....|.|::..|....:  ::.|..::........|...|||
Zfish   443 SWRCDGQVDCKDGTDELNCTATLPRKVITAATVGS--LVCGLLLVIAMGCTCKLYSLRTREYSLF 505

  Fly  1477 --IGKSRTEPKDDQATDPLSPSTLSKSQRVSK--IASVADAVRMSTLNSRNSMNSYDRNHITGAS 1537
              |.:...|....||..       |..|.:::  |..|.|   ..|.|...:::...|..:....
Zfish   506 APITRQEAELIQQQAPP-------SYGQLIAQGIIPPVED---FPTENPNETVSLSLRGILQLLR 560

  Fly  1538 SSTTNGSSMVAYPINPPPSPATRSRRP---------YRHYKII----NQPPPPTPCSTDICDESD 1589
            ..  |.||:            .|.|||         .|.:.:|    ::|...|..|:...:.::
Zfish   561 QD--NASSL------------RRRRRPRFVRRAVRRLRRWGLIPRATSRPTQTTASSSQQTEAAN 611

  Fly  1590 SNYTSKSNSNNSNGGATKHSSSSAAACLQYGYDSE-----------PYPPPPTPRSHYHS-DVRI 1642
            |:.....:|..::..||:..|.|....|.....:|           |.||||.|.....| :.:.
Zfish   612 SSTQPSQSSPGASSVATEAFSQSLTQKLGLSQQTETQQQAEAPPPSPSPPPPFPFQPVESAEAQQ 676

  Fly  1643 VPESSCPPSPSS---------RSSTYFSPLPPPPSPVQSPSRGFT 1678
            .|..:.|||..|         ||.:.|.|.|...|...|.|..|:
Zfish   677 TPPITAPPSSPSLASLFHTLGRSISRFRPSPSTTSLPLSASPSFS 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arr	NP_524737.2	LY	162..201	CDD:214531
		NHL	168..503	CDD:302697
		NHL repeat	172..237	CDD:271320
		LY	252..293	CDD:214531
		NHL repeat	261..298	CDD:271320
		NHL repeat	303..339	CDD:271320
		NHL repeat	341..419	CDD:271320
		NHL repeat	428..476	CDD:271320
		LY	472..511	CDD:214531
		NHL repeat	477..503	CDD:271320
		Ldl_recept_b	534..573	CDD:278487
		LY	558..599	CDD:214531
		LY	600..641	CDD:214531
		FXa_inhibition	668..703	CDD:291342
		LY	739..773	CDD:214531
		LY	776..818	CDD:214531
		LY	819..860	CDD:214531
		FXa_inhibition	973..1010	CDD:291342	7/36 (19%)
		LY	1122..1164	CDD:214531	7/41 (17%)
		FXa_inhibition	1273..1313	CDD:291342	3/39 (8%)
		LDLa	1319..1362	CDD:238060	15/43 (35%)
		LDLa	1365..1399	CDD:238060	12/45 (27%)
		LDLa	1399..1433	CDD:197566	13/35 (37%)
lrp10	XP_688859.4	CUB	36..136	CDD:238001	26/126 (21%)
		LDLa	142..181	CDD:238060	3/38 (8%)
		CUB	229..334	CDD:294042	29/194 (15%)
		LDLa	427..461	CDD:238060	14/35 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590473
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830