DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and lrp1bb

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:XP_021334671.1 Gene:lrp1bb / 559293 ZFINID:ZDB-GENE-070912-401 Length:4600 Species:Danio rerio


Alignment Length:1669 Identity:475/1669 - (28%)
Similarity:779/1669 - (46%) Gaps:269/1669 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 EPYTKSAEIEPQLC----QVIDNNEDVTTKA------TKCTKSNSGVGWRQMLI---GFLLIC-- 53
            :|.|:....:..:|    ::.|...|...::      .:|.:.|.|...:..:|   |.:..|  
Zfish  1105 KPPTQPCANDSSICLPQNKICDGRMDCADRSDEGPFCERCLQGNGGCSHQCSVIPSKGVVCSCPA 1169

  Fly    54 ---FGISN----SWQYKNVHMPSS------------------------SSLIASPPASAFVNTPA 87
               .|..|    :..|.:.|:..|                        .|..::.|..|||    
Zfish  1170 GLHLGSDNRTCEAVDYCSAHLKCSQICEQHKTTVKCSCYPGWRLDADGESCHSTDPFEAFV---- 1230

  Fly    88 TLLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDSGREII---ECAQTN 149
              :|:.||:|:..::.:    ....::|..|...:|:||:::.:|:.|||...:.|   :.::|.
Zfish  1231 --IFSIRHEIRRIDLHK----HDYSLLVPGLRNTIALDFHFSHSLLYWTDVVEDKIYRGKLSETG 1289

  Fly   150 SSALQPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQ 214
            ..       ...:.||..||..|||||:||....:||.|...::||||.|:|..:..|....::.
Zfish  1290 GV-------TGVEVVIQHGLATPEGLAVDWIAGNLYWIDSNLDQIEVAKLNGEMRTTLIAGGMEH 1347

  Fly   215 PRAVAVVPARKLLIWTDW-GEYPKIERASMDGDPLSRMTLVKEHVF--WPNGLAVDLKNELIYWT 276
            |||:||.|.:.:|.|||| ..:|:||..||.|.  .|..:.|:...  |||||.:|.:...|.||
Zfish  1348 PRALAVDPGQGILFWTDWDATFPRIEATSMSGS--GRHVVYKDMEIGAWPNGLTLDHQERRIVWT 1410

  Fly   277 DGKHHFIDVMRLDGSSRRTIVNN---LKYPFSLTFYDDRLYWTDWQRGSLNALDLQTRELKELID 338
            |.:...|.....|||....|:..   |.:||:::.:...:|||||:..:|...:..|.....:|.
Zfish  1411 DARSDAIYSALYDGSGVIEILRGHEYLSHPFAVSLFGGGVYWTDWRTNTLARANKWTGHNVTVIQ 1475

  Fly   339 -TPKAPNSVRAWDPSLQPYEDNPCAHNNGN--CSHLCLLATNSQGFSCACPTGVKLISANTCANG 400
             |...|..:..:.||.||...|||..|:|.  ||||||:..|... ||:||..:||...|.....
Zfish  1476 KTSAQPFDLEIYHPSRQPQASNPCEGNDGRGPCSHLCLIDYNRTA-SCSCPHLMKLSLNNRSCVA 1539

  Fly   401 SQEMMFIVQRTQISKISLDSPDYTIF-PLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHAD 464
            .::.:..|:|::|..:.:|:|...:. .|.:..:.....:|||.:||.|||:||:|.|||||..:
Zfish  1540 LKKFLLYVRRSEIRGVDIDNPYMNVMTALTVPDIDDVTVVDYDALEERIYWADVKTQTIKRAFIN 1604

  Fly   465 GTGVTDFVTSEVRHPDGLALDWLARNLYWTDTVTD--RIEVCRLDGTARKVLIYEHLEEPRAIAV 527
            |||:...::.::::..|||:|||:||:||..:..:  :|.|.||||:.:..:|: .:::|:.:.|
Zfish  1605 GTGLQTVISGDIQNCRGLAIDWLSRNMYWLSSENEETQINVARLDGSLKTSVIH-GIDKPKCLTV 1668

  Fly   528 APSLGWMFWSDWNERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVA 592
            .|:.|.::|:|.|    .:..|::|||.|.|| .:|...|.|:::|..|..:||.......|...
Zfish  1669 HPAKGKIYWTDGN----TINVANMDGSNRKVL-HQNQKEPVGLSIDFPAGKMYWISSANGTINRC 1728

  Fly   593 NMDGSGRRVV--ISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGLK 655
            |:||||..|:  :..:|.....|:::...|:|.|.....:....|..|.|.:|:.::...|:.:|
Zfish  1729 NLDGSGFEVIESMKRDLTKATALAVMGGKLWWADDDLAQLGTVAKRDGRNPVVLRNKTSGLVHMK 1793

  Fly   656 VTRLREVRGQNACAVRNGGCSHLCL-NRPRDYVCRCAIDYELANDKRTCVVPAAFLLFSRQEHIG 719
            |......:|:|||.:.|||||.||| .......|.|.|.|.|.||:.:|....:||::|..|.|.
Zfish  1794 VYDRDGQKGRNACQLNNGGCSQLCLPTSENTRTCACTIGYNLRNDRLSCEGLNSFLMYSFHEGIR 1858

  Fly   720 RISIEYNEGNHNDERIPFKDVRDAHALDVSVAERRIYWTDQKSKCIFRAFLNGSYVQRIVDSGLI 784
            .|:::.|:  |.:..:|......|..:|.......:||||.....|.||..:.::.:.|:.:|:.
Zfish  1859 GIALDPND--HTETLMPISGTLFAVGVDFHAGNDTVYWTDMGLNRISRAKRDQTWREDIITTGIN 1921

  Fly   785 GPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTE-SPT 848
            ..:||||||:|.|:||:|.....||:|||:|..|.|::.:|:::||::.:.|:|||::||| ...
Zfish  1922 RVEGIAVDWIAGNLYWTDHGLNLIEIARLNGLYRSVVISEGLDQPRAIAVHPQRGYLFWTEWGKN 1986

  Fly   849 DSIRRAAMDGSDLQTIV-AGANHAAGLTFDQETRRLYWATQSRPAKIESADWD-GKKRQILVGSD 911
            ..|.||.:||||..|:| :|.....|:|.|.|..||||. .:|..|||..:.: |:.|:|::.:.
Zfish  1987 PCIGRARLDGSDQVTLVSSGIAWPNGITIDYEENRLYWC-DARTDKIERINLETGEGREIVLSAA 2050

  Fly   912 MDEPYAVSLYQDYVYWSD--WNTGDIERVHKTTGQNRSLVHSGM-TYITSLLVFNDKRQTGVNPC 973
            ..:.::|:::..|:||||  ...|.|.|..|:...:...:.||: ..:..:.|||..|:.|.|||
Zfish  2051 NVDLFSVAVFGAYIYWSDRAHANGSIRRGFKSDATDAVTMRSGLGVNLKDVKVFNKGREKGTNPC 2115

  Fly   974 KVNNGGCSHLCL-AQPGRRGMTCACPTHYQLAKDGVSCIPPRNYIIFSQRNCFGRL-LPNTTDCP 1036
            ..:||||..||. ...|||  ||:| .|..||:||.:|.....|:::|:|.....: |.:.:|. 
Zfish  2116 ARSNGGCQQLCFHLGSGRR--TCSC-AHGYLAEDGFACQRYGGYLLYSERTILKSIHLSDESDL- 2176

  Fly  1037 NIPL-----PVSGKNIRAVDYDPITHHIYWIEGRSHS-------------IKRSLANGTKVSLLA 1083
            |.||     |...||:.|:.:|      |..|...|:             :.....:|.:| ::.
Zfish  2177 NSPLQPFENPDYFKNVIALAFD------YRQESSPHNRIFFSDIHFGNIQMINDDWSGRQV-IVE 2234

  Fly  1084 NSGQPFDLAIDIIGRLLFWTCSQSNSINVTSFLGESVG------VIDTGDSEKPRNIAVHAMKRL 1142
            |.|....||.......::||.|.::||:..:......|      |:...:.:.|..:|:...:.|
Zfish  2235 NVGSVEGLAYHRAWDTIYWTSSTTSSISRYTVDQSRQGAFGRQAVVTMSEDDHPHVLALDECQNL 2299

  Fly  1143 LFWTDVGSHQ-AIIRARVDGNE-RVELAYKLEGVTALALDQQSDMIYYAHGK--RIDAIDINGKN 1203
            :|||:....: :|:|:.:.||. :|.::..:.....|.:|.:::.:|::.|.  :|:..:.:|.:
Zfish  2300 MFWTNWNEQRPSIMRSTLAGNNMKVIISTDVFTPNGLTIDHKAEKLYFSDGSLGKIERCEYDGSH 2364

  Fly  1204 KKTLVSMHISQVINIAALGGFVYWLD-DKTGVERIT--VNGERR--SAELQRLP----------- 1252
            :..:|.........:|..|.:::|.| .:..|.|..  ..||.:  .|::...|           
Zfish  2365 RHVIVRSGPGTFFGLAIHGNYIFWSDWTRRAVLRTNKFTGGETKVLRADIPHQPMGIIAVAKDTN 2429

  Fly  1253 --QITDIR---------AVWTPDPKV----------LRNHTCMHSRTKCS-HI--------CI-- 1285
              :::..|         .:.|||..|          |.::.|:...:.|: |.        ||  
Zfish  2430 NCELSPCRVQNGGCGDLCLLTPDGTVNCSCRGERVLLDDNRCVSKTSSCNIHTEFECGNGECIDY 2494

  Fly  1286 -ASGEGIARTRD-------VC---SCPK------HLMLLEDKENCGAFPACGP-------DHFTC 1326
             .:.:|||..:|       .|   ||.|      :...:.:...|.....||.       ::.||
Zfish  2495 QLTCDGIAHCKDKSDEKMQYCDNRSCRKGHRPCYNRRCVANSRFCDGIDDCGDNSDEAFCNNVTC 2559

  Fly  1327 AA-----------PVS-----------------------------GISD-------VNKDCIPAS 1344
            ||           |:|                             |:::       ....|:..|
Zfish  2560 AASESSCQDGTCIPISSWCNQVIDCADASDEKNCNHTDCTDFYRIGVAEKVFVSCNTTSLCVHHS 2624

  Fly  1345 WRCDGQKDCPDKSDEVGCPT-----CRADQFSCQSGECIDKSLVCDGTTNCANGHDEADC---CK 1401
            |.|||..||.|.:||..|..     |....|:|.||.||....:|||..:|.:|.||..|   |.
Zfish  2625 WLCDGANDCGDYADERNCQVSQGQKCAEGHFACPSGNCISSVWLCDGQKDCEDGADEFQCDSSCL 2689

  Fly  1402 RPGEFQCPINKLCISAALLCDGWENCADGADESSDICLQRRMAP 1445
            . .:|.|..|| ||:...||||.::|.||.|||.|:|.....||
Zfish  2690 W-NQFACSKNK-CIAKQWLCDGEDDCGDGVDESVDLCGSVTCAP 2731

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 19/38 (50%)
NHL 168..503 CDD:302697 125/346 (36%)
NHL repeat 172..237 CDD:271320 28/65 (43%)
LY 252..293 CDD:214531 15/42 (36%)
NHL repeat 261..298 CDD:271320 14/36 (39%)
NHL repeat 303..339 CDD:271320 10/36 (28%)
NHL repeat 341..419 CDD:271320 27/79 (34%)
NHL repeat 428..476 CDD:271320 20/47 (43%)
LY 472..511 CDD:214531 16/40 (40%)
NHL repeat 477..503 CDD:271320 11/27 (41%)
Ldl_recept_b 534..573 CDD:278487 13/38 (34%)
LY 558..599 CDD:214531 14/40 (35%)
LY 600..641 CDD:214531 8/42 (19%)
FXa_inhibition 668..703 CDD:291342 16/35 (46%)
LY 739..773 CDD:214531 9/33 (27%)
LY 776..818 CDD:214531 19/41 (46%)
LY 819..860 CDD:214531 16/41 (39%)
FXa_inhibition 973..1010 CDD:291342 18/37 (49%)
LY 1122..1164 CDD:214531 11/43 (26%)
FXa_inhibition 1273..1313 CDD:291342 13/67 (19%)
LDLa 1319..1362 CDD:238060 20/96 (21%)
LDLa 1365..1399 CDD:238060 14/33 (42%)
LDLa 1399..1433 CDD:197566 15/36 (42%)
lrp1bbXP_021334671.1 LDLa 38..76 CDD:294076
FXa_inhibition 128..156 CDD:317114
LY 238..274 CDD:214531
LY 282..324 CDD:214531
LY 326..367 CDD:214531
FXa_inhibition 452..484 CDD:317114
LY 516..558 CDD:214531
LY 559..598 CDD:214531
LY 605..654 CDD:214531
LY 655..697 CDD:214531
FXa_inhibition 766..801 CDD:317114
LDLa 854..887 CDD:238060
LDLa 895..926 CDD:197566
LDLa 939..970 CDD:238060
LDLa 974..1005 CDD:197566
LDLa 1021..1056 CDD:238060
LDLa 1065..1099 CDD:238060
FXa_inhibition 1144..1180 CDD:317114 8/35 (23%)
FXa_inhibition 1192..1220 CDD:317114 1/27 (4%)
LY 1248..1289 CDD:214531 10/40 (25%)
LY 1295..1337 CDD:214531 20/41 (49%)
LY 1339..1382 CDD:214531 18/44 (41%)
LY <1394..1427 CDD:214531 14/32 (44%)
Ldl_recept_b 1586..1625 CDD:278487 18/38 (47%)
LY 1609..1651 CDD:214531 15/41 (37%)
LY 1653..1693 CDD:214531 12/44 (27%)
LY <1703..1734 CDD:214531 10/30 (33%)
FXa_inhibition 1806..1842 CDD:317114 16/35 (46%)
NHL <1858..1941 CDD:302697 26/84 (31%)
NHL repeat 1879..1916 CDD:271320 9/36 (25%)
LY 1915..1955 CDD:214531 19/39 (49%)
Ldl_recept_b 1976..2016 CDD:278487 17/39 (44%)
LY 2001..2041 CDD:214531 15/40 (38%)
FXa_inhibition 2115..2150 CDD:317114 18/37 (49%)
Ldl_recept_b 2298..2339 CDD:278487 10/40 (25%)
LY 2323..2365 CDD:214531 7/41 (17%)
FXa_inhibition 2436..2470 CDD:317114 6/33 (18%)
LDLa 2482..2511 CDD:238060 6/28 (21%)
LDLa 2520..2554 CDD:238060 5/33 (15%)
LDLa 2559..2593 CDD:238060 5/33 (15%)
LDLa <2613..2642 CDD:294076 11/28 (39%)
LDLa 2650..2684 CDD:238060 14/33 (42%)
LDLa 2688..2719 CDD:238060 14/32 (44%)
LDLa 2728..2761 CDD:197566 2/4 (50%)
LDLa 2772..2804 CDD:197566
LDLa 2813..2846 CDD:238060
LDLa 2859..2893 CDD:238060
cEGF 2916..2939 CDD:315355
EGF_CA 2936..2969 CDD:214542
LY 3003..3047 CDD:214531
LY 3050..3086 CDD:214531
LY 3135..3174 CDD:214531
FXa_inhibition 3245..3281 CDD:317114
LDLa 3285..3316 CDD:197566
LDLa 3325..3359 CDD:238060
LDLa 3364..3399 CDD:238060
LDLa 3404..3439 CDD:238060
LDLa 3444..3478 CDD:238060
LDLa 3483..3517 CDD:238060
LDLa 3521..3555 CDD:238060
LDLa 3563..3597 CDD:238060
LDLa 3601..3636 CDD:238060
LDLa 3643..3675 CDD:238060
LDLa 3730..3765 CDD:238060
Ldl_recept_b 4008..4048 CDD:278487
LY 4032..4073 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170590478
Domainoid 1 1.000 89 1.000 Domainoid score I7812
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.640

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