DRSC/TRiP Functional Genomics Resources

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Protein Alignment arr and lrp1bb

DIOPT Version :10

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:XP_073769005.1 Gene:lrp1bb / 559293 ZFINID:ZDB-GENE-070912-401 Length:4666 Species:Danio rerio


Alignment Length:1669 Identity:475/1669 - (28%)
Similarity:779/1669 - (46%) Gaps:269/1669 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 EPYTKSAEIEPQLC----QVIDNNEDVTTKA------TKCTKSNSGVGWRQMLI---GFLLIC-- 53
            :|.|:....:..:|    ::.|...|...::      .:|.:.|.|...:..:|   |.:..|  
Zfish  1171 KPPTQPCANDSSICLPQNKICDGRMDCADRSDEGPFCERCLQGNGGCSHQCSVIPSKGVVCSCPA 1235

  Fly    54 ---FGISN----SWQYKNVHMPSS------------------------SSLIASPPASAFVNTPA 87
               .|..|    :..|.:.|:..|                        .|..::.|..|||    
Zfish  1236 GLHLGSDNRTCEAVDYCSAHLKCSQICEQHKTTVKCSCYPGWRLDADGESCHSTDPFEAFV---- 1296

  Fly    88 TLLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDSGREII---ECAQTN 149
              :|:.||:|:..::.:    ....::|..|...:|:||:::.:|:.|||...:.|   :.::|.
Zfish  1297 --IFSIRHEIRRIDLHK----HDYSLLVPGLRNTIALDFHFSHSLLYWTDVVEDKIYRGKLSETG 1355

  Fly   150 SSALQPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQ 214
            ..       ...:.||..||..|||||:||....:||.|...::||||.|:|..:..|....::.
Zfish  1356 GV-------TGVEVVIQHGLATPEGLAVDWIAGNLYWIDSNLDQIEVAKLNGEMRTTLIAGGMEH 1413

  Fly   215 PRAVAVVPARKLLIWTDW-GEYPKIERASMDGDPLSRMTLVKEHVF--WPNGLAVDLKNELIYWT 276
            |||:||.|.:.:|.|||| ..:|:||..||.|.  .|..:.|:...  |||||.:|.:...|.||
Zfish  1414 PRALAVDPGQGILFWTDWDATFPRIEATSMSGS--GRHVVYKDMEIGAWPNGLTLDHQERRIVWT 1476

  Fly   277 DGKHHFIDVMRLDGSSRRTIVNN---LKYPFSLTFYDDRLYWTDWQRGSLNALDLQTRELKELID 338
            |.:...|.....|||....|:..   |.:||:::.:...:|||||:..:|...:..|.....:|.
Zfish  1477 DARSDAIYSALYDGSGVIEILRGHEYLSHPFAVSLFGGGVYWTDWRTNTLARANKWTGHNVTVIQ 1541

  Fly   339 -TPKAPNSVRAWDPSLQPYEDNPCAHNNGN--CSHLCLLATNSQGFSCACPTGVKLISANTCANG 400
             |...|..:..:.||.||...|||..|:|.  ||||||:..|... ||:||..:||...|.....
Zfish  1542 KTSAQPFDLEIYHPSRQPQASNPCEGNDGRGPCSHLCLIDYNRTA-SCSCPHLMKLSLNNRSCVA 1605

  Fly   401 SQEMMFIVQRTQISKISLDSPDYTIF-PLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHAD 464
            .::.:..|:|::|..:.:|:|...:. .|.:..:.....:|||.:||.|||:||:|.|||||..:
Zfish  1606 LKKFLLYVRRSEIRGVDIDNPYMNVMTALTVPDIDDVTVVDYDALEERIYWADVKTQTIKRAFIN 1670

  Fly   465 GTGVTDFVTSEVRHPDGLALDWLARNLYWTDTVTD--RIEVCRLDGTARKVLIYEHLEEPRAIAV 527
            |||:...::.::::..|||:|||:||:||..:..:  :|.|.||||:.:..:|: .:::|:.:.|
Zfish  1671 GTGLQTVISGDIQNCRGLAIDWLSRNMYWLSSENEETQINVARLDGSLKTSVIH-GIDKPKCLTV 1734

  Fly   528 APSLGWMFWSDWNERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVA 592
            .|:.|.::|:|.|    .:..|::|||.|.|| .:|...|.|:::|..|..:||.......|...
Zfish  1735 HPAKGKIYWTDGN----TINVANMDGSNRKVL-HQNQKEPVGLSIDFPAGKMYWISSANGTINRC 1794

  Fly   593 NMDGSGRRVV--ISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGLK 655
            |:||||..|:  :..:|.....|:::...|:|.|.....:....|..|.|.:|:.::...|:.:|
Zfish  1795 NLDGSGFEVIESMKRDLTKATALAVMGGKLWWADDDLAQLGTVAKRDGRNPVVLRNKTSGLVHMK 1859

  Fly   656 VTRLREVRGQNACAVRNGGCSHLCL-NRPRDYVCRCAIDYELANDKRTCVVPAAFLLFSRQEHIG 719
            |......:|:|||.:.|||||.||| .......|.|.|.|.|.||:.:|....:||::|..|.|.
Zfish  1860 VYDRDGQKGRNACQLNNGGCSQLCLPTSENTRTCACTIGYNLRNDRLSCEGLNSFLMYSFHEGIR 1924

  Fly   720 RISIEYNEGNHNDERIPFKDVRDAHALDVSVAERRIYWTDQKSKCIFRAFLNGSYVQRIVDSGLI 784
            .|:::.|:  |.:..:|......|..:|.......:||||.....|.||..:.::.:.|:.:|:.
Zfish  1925 GIALDPND--HTETLMPISGTLFAVGVDFHAGNDTVYWTDMGLNRISRAKRDQTWREDIITTGIN 1987

  Fly   785 GPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTE-SPT 848
            ..:||||||:|.|:||:|.....||:|||:|..|.|::.:|:::||::.:.|:|||::||| ...
Zfish  1988 RVEGIAVDWIAGNLYWTDHGLNLIEIARLNGLYRSVVISEGLDQPRAIAVHPQRGYLFWTEWGKN 2052

  Fly   849 DSIRRAAMDGSDLQTIV-AGANHAAGLTFDQETRRLYWATQSRPAKIESADWD-GKKRQILVGSD 911
            ..|.||.:||||..|:| :|.....|:|.|.|..||||. .:|..|||..:.: |:.|:|::.:.
Zfish  2053 PCIGRARLDGSDQVTLVSSGIAWPNGITIDYEENRLYWC-DARTDKIERINLETGEGREIVLSAA 2116

  Fly   912 MDEPYAVSLYQDYVYWSD--WNTGDIERVHKTTGQNRSLVHSGM-TYITSLLVFNDKRQTGVNPC 973
            ..:.::|:::..|:||||  ...|.|.|..|:...:...:.||: ..:..:.|||..|:.|.|||
Zfish  2117 NVDLFSVAVFGAYIYWSDRAHANGSIRRGFKSDATDAVTMRSGLGVNLKDVKVFNKGREKGTNPC 2181

  Fly   974 KVNNGGCSHLCL-AQPGRRGMTCACPTHYQLAKDGVSCIPPRNYIIFSQRNCFGRL-LPNTTDCP 1036
            ..:||||..||. ...|||  ||:| .|..||:||.:|.....|:::|:|.....: |.:.:|. 
Zfish  2182 ARSNGGCQQLCFHLGSGRR--TCSC-AHGYLAEDGFACQRYGGYLLYSERTILKSIHLSDESDL- 2242

  Fly  1037 NIPL-----PVSGKNIRAVDYDPITHHIYWIEGRSHS-------------IKRSLANGTKVSLLA 1083
            |.||     |...||:.|:.:|      |..|...|:             :.....:|.:| ::.
Zfish  2243 NSPLQPFENPDYFKNVIALAFD------YRQESSPHNRIFFSDIHFGNIQMINDDWSGRQV-IVE 2300

  Fly  1084 NSGQPFDLAIDIIGRLLFWTCSQSNSINVTSFLGESVG------VIDTGDSEKPRNIAVHAMKRL 1142
            |.|....||.......::||.|.::||:..:......|      |:...:.:.|..:|:...:.|
Zfish  2301 NVGSVEGLAYHRAWDTIYWTSSTTSSISRYTVDQSRQGAFGRQAVVTMSEDDHPHVLALDECQNL 2365

  Fly  1143 LFWTDVGSHQ-AIIRARVDGNE-RVELAYKLEGVTALALDQQSDMIYYAHGK--RIDAIDINGKN 1203
            :|||:....: :|:|:.:.||. :|.::..:.....|.:|.:::.:|::.|.  :|:..:.:|.:
Zfish  2366 MFWTNWNEQRPSIMRSTLAGNNMKVIISTDVFTPNGLTIDHKAEKLYFSDGSLGKIERCEYDGSH 2430

  Fly  1204 KKTLVSMHISQVINIAALGGFVYWLD-DKTGVERIT--VNGERR--SAELQRLP----------- 1252
            :..:|.........:|..|.:::|.| .:..|.|..  ..||.:  .|::...|           
Zfish  2431 RHVIVRSGPGTFFGLAIHGNYIFWSDWTRRAVLRTNKFTGGETKVLRADIPHQPMGIIAVAKDTN 2495

  Fly  1253 --QITDIR---------AVWTPDPKV----------LRNHTCMHSRTKCS-HI--------CI-- 1285
              :::..|         .:.|||..|          |.::.|:...:.|: |.        ||  
Zfish  2496 NCELSPCRVQNGGCGDLCLLTPDGTVNCSCRGERVLLDDNRCVSKTSSCNIHTEFECGNGECIDY 2560

  Fly  1286 -ASGEGIARTRD-------VC---SCPK------HLMLLEDKENCGAFPACGP-------DHFTC 1326
             .:.:|||..:|       .|   ||.|      :...:.:...|.....||.       ::.||
Zfish  2561 QLTCDGIAHCKDKSDEKMQYCDNRSCRKGHRPCYNRRCVANSRFCDGIDDCGDNSDEAFCNNVTC 2625

  Fly  1327 AA-----------PVS-----------------------------GISD-------VNKDCIPAS 1344
            ||           |:|                             |:::       ....|:..|
Zfish  2626 AASESSCQDGTCIPISSWCNQVIDCADASDEKNCNHTDCTDFYRIGVAEKVFVSCNTTSLCVHHS 2690

  Fly  1345 WRCDGQKDCPDKSDEVGCPT-----CRADQFSCQSGECIDKSLVCDGTTNCANGHDEADC---CK 1401
            |.|||..||.|.:||..|..     |....|:|.||.||....:|||..:|.:|.||..|   |.
Zfish  2691 WLCDGANDCGDYADERNCQVSQGQKCAEGHFACPSGNCISSVWLCDGQKDCEDGADEFQCDSSCL 2755

  Fly  1402 RPGEFQCPINKLCISAALLCDGWENCADGADESSDICLQRRMAP 1445
            . .:|.|..|| ||:...||||.::|.||.|||.|:|.....||
Zfish  2756 W-NQFACSKNK-CIAKQWLCDGEDDCGDGVDESVDLCGSVTCAP 2797

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 19/38 (50%)
NHL 168..503 CDD:302697 125/346 (36%)
NHL repeat 172..237 CDD:271320 28/65 (43%)
LY 252..293 CDD:214531 15/42 (36%)
NHL repeat 261..298 CDD:271320 14/36 (39%)
NHL repeat 303..339 CDD:271320 10/36 (28%)
NHL repeat 341..419 CDD:271320 27/79 (34%)
NHL repeat 428..476 CDD:271320 20/47 (43%)
LY 472..511 CDD:214531 16/40 (40%)
NHL repeat 477..503 CDD:271320 11/27 (41%)
Ldl_recept_b 534..574 CDD:459654 13/39 (33%)
LY 558..599 CDD:214531 14/40 (35%)
LY 600..641 CDD:214531 8/42 (19%)
FXa_inhibition 668..703 CDD:464251 16/35 (46%)
YncE <736..886 CDD:442618 58/151 (38%)
LY 776..818 CDD:214531 19/41 (46%)
LY 905..946 CDD:214531 11/42 (26%)
FXa_inhibition 973..1010 CDD:464251 18/37 (49%)
YncE <1047..1191 CDD:442618 32/164 (20%)
LDLa 1319..1362 CDD:238060 20/96 (21%)
LDLa 1365..1399 CDD:238060 14/33 (42%)
LDLa 1399..1433 CDD:197566 15/36 (42%)
lrp1bbXP_073769005.1 None

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