DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and LRP2

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:NP_004516.2 Gene:LRP2 / 4036 HGNCID:6694 Length:4655 Species:Homo sapiens


Alignment Length:1684 Identity:470/1684 - (27%)
Similarity:742/1684 - (44%) Gaps:297/1684 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 LLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECAQTNSSAL 153
            ||..:::.|...::|...  ..|..:|.:.:..:|:||......:.|:|:.:.....|..|.:  
Human  1438 LLVASQNKIIADSVTSQV--HNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGT-- 1498

  Fly   154 QPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAV 218
                  .::.|..:.:...|.:|:||....:||||.....|||:.:||.::.||...:|..||.:
Human  1499 ------DRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGL 1557

  Fly   219 AVVPA--RKLLIWTDWGEYPKIERASMDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYWTDGKHH 281
            |:.|.  ..||.|:|||.:|:||||||||.  .|..:|::.:|||.||.:|..|.|:|:.|....
Human  1558 ALDPRMNEHLLFWSDWGHHPRIERASMDGS--MRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLD 1620

  Fly   282 FIDVMRLDGSSRRTIVNN---LKYPFSLTFYDDRLYWTD-----------WQRGSLNAL--DLQT 330
            ::|....:|..||.::.:   :::|::||.::|.:||||           |..|:.:.:  ::|.
Human  1621 YMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQW 1685

  Fly   331 RELKELIDTPKAPNSVRAWDPSLQPYEDNPCAHNNGNCSHLCLLATNSQG---FSCACPTGVKLI 392
                        |..:.|..||.||...||||.:  .|||||||  :|||   :||.||:|..|.
Human  1686 ------------PLGIVAVHPSKQPNSVNPCAFS--RCSHLCLL--SSQGPHFYSCVCPSGWSLS 1734

  Fly   393 -SANTCANGSQEMMFIVQRTQISKISLD----SPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSD 452
             ....|....|..:..|::..|..|||:    |.|..:   |:..::..:.:::|..|::|||.:
Human  1735 PDLLNCLRDDQPFLITVRQHIIFGISLNPEVKSNDAMV---PIAGIQNGLDVEFDDAEQYIYWVE 1796

  Fly   453 VETYTIKRAHADGTGVTDFVTSEVRHPD-GLALDWLARNLYWTDTVTDRIEVCRLDGTA--RKVL 514
             ....|.|...|||..|.|.:..:..|. .|||||::||||.|:..|..|||..|.|..  ||.|
Human  1797 -NPGEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTL 1860

  Fly   515 IYEH-----LEEPRAIAVAPSLGWMFWSDWNERK---PKVERASLDGSERVVLVSENLGWPNGIA 571
            |...     :..|..|.|.|:.|.::|||.....   .|:..|::||:....|.:.||.....:.
Human  1861 IANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVT 1925

  Fly   572 LDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKI 636
            ||||.:.:||.......||..|:||:.|.::: ..|.|.:|:::.|.:||:||.|...|:|..|.
Human  1926 LDIEEQKLYWAVTGRGVIERGNVDGTDRMILV-HQLSHPWGIAVHDSFLYYTDEQYEVIERVDKA 1989

  Fly   637 TGNNRIVVVDQYPDLMGLKVTRLRE-VRGQNACAVRNGGCSHLCLNRPRD-YVCRCAIDYELAND 699
            ||.|:||:.|..|:|.||:|...|. ....|.|:.....|..:||..|.. :.|.||..::|..|
Human  1990 TGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPD 2054

  Fly   700 KRTCVVPAAFLLFSRQEHIGRISIEYNEGNHNDERIPFK-DVRDAHALDVSVAERRIYWTDQKS- 762
            .|:|....:|::.|....|...|:|.::  |::..:|.. ..|:|..:||.|:...|||.|..| 
Human  2055 NRSCSPYNSFIVVSMLSAIRGFSLELSD--HSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSS 2117

  Fly   763 ----KCIFRAFLNGSYVQRIVDSGL--IGPDGIAVDWLANNIYWSDA--EARRIEVARLDGSSRR 819
                ..|.|...:||.:..||..|:  .|..||||||:|.|:|:::|  ....|||.|::.:.||
Human  2118 VASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRR 2182

  Fly   820 VLLWKGVEEPRSLVLEPRRGYMYWTE-SPTDSIRRAAMDGSDLQTIVA-GANHAAGLTFDQETRR 882
            |||...|:.||.:|::|:..|::|.: .....|.|:.:|.::...:|: |.....||..|:....
Human  2183 VLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGY 2247

  Fly   883 LYWATQSRP--AKIESADWDGKKRQIL-VGSDMDEPYAVSLYQDYVYWSDWNTGDIERVHKTTGQ 944
            :||...|..  |:|..   :|:..::: .||....||.::::::.:.|.|.|...|.:..|....
Human  2248 VYWVDDSLDIIARIRI---NGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEPEN 2309

  Fly   945 NR--SLVHSGMTYITSLLVFNDKR-------QTGVNPCKVNNGGCSHLCLAQPGRRGMTCACPTH 1000
            ..  :::...:.::..:.:| ||:       :...|||..|||||||||.|.||.....|.| ..
Human  2310 TEPPTVIRDNINWLRDVTIF-DKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPKCDC-AF 2372

  Fly  1001 YQLAKDGVSC-IPPRNYIIFSQRNCFG--RLLPNTTDCPNIPLPVSGKNIRAVDYDPITHHIYWI 1062
            ..|..||.:| |...|::||:..|...  .|.|.....|...:.|. :.:.::|||.::..||:.
Human  2373 GTLQSDGKNCAISTENFLIFALSNSLRSLHLDPENHSPPFQTINVE-RTVMSLDYDSVSDRIYFT 2436

  Fly  1063 EGRSHSIKR----SLANG--TKVSLLANSGQPFDLAIDIIGRLLFWTCSQSNSINVTSFLGESVG 1121
            :..:..:.:    :|::|  |...:.:..|....:|.|.|.|.::::...:..||..:..|.:..
Human  2437 QNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRT 2501

  Fly  1122 VIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQAIIRARVDGNERVELA-YKLEGVTALALDQQSDM 1185
            ||  ....|||.|.:...:..|:|.|..:|..|.||.:.||.||.:. ..|...:.|.||.:.|:
Human  2502 VI--ARVPKPRAIVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDL 2564

  Fly  1186 IYY--AHGKRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLD------------DKTGVER 1236
            :|:  |..:||:...:.|.:::.:|:..: ....:...|.::||.|            |.:|...
Human  2565 LYWVDASLQRIERSTLTGVDREVIVNAAV-HAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIA 2628

  Fly  1237 ITVNGERRSAELQRLPQITDIRAVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIARTRDVCSCP 1301
            :|.|         .|.|...|..| ..:.|...|:.|......|||||.....|..     |.||
Human  2629 MTTN---------LLSQPRGINTV-VKNQKQQCNNPCEQFNGGCSHICAPGPNGAE-----CQCP 2678

  Fly  1302 -----------KHLMLLEDKENCGAFPACGPDHFTCAAPVSGISDVNKDCIPASWRCDGQKDCPD 1355
                       || .::::.|.|||      ..|||:         |..||...|:||...||.|
Human  2679 HEGNWYLANNRKH-CIVDNGERCGA------SSFTCS---------NGRCISEEWKCDNDNDCGD 2727

  Fly  1356 KSDEV----GCPTCRADQFSCQSGECIDKSLVCDGTTNCANGHDEADC----CKRPGEFQCPINK 1412
            .|||:    ...||....|:|.:|.|:..|..||...:|.:|.|||.|    |....||.|. |:
Human  2728 GSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCN-NR 2791

  Fly  1413 LCISAALLCDGWENCADG--ADE----------------SSDICLQRRMAPATDKRAFMILIGAT 1459
            .||....:|:|.:||.|.  :||                :|:||:.|                  
Human  2792 RCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPR------------------ 2838

  Fly  1460 MITIFSIVYLLQ--------------FCRT--------RIGKSRTEPKD---DQATDPLSPSTLS 1499
                   |||..              :|.|        :....|..|:.   ||.||....|...
Human  2839 -------VYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEP 2896

  Fly  1500 KSQRVSKIASVADAVR------------MSTLNSRNSMNSYDRNHITGASSSTTNGSSMVAYPIN 1552
            .|...|:...:||..:            ....|....|:..|:.|    .....|.|.       
Human  2897 ASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRH----QCQNQNCSD------- 2950

  Fly  1553 PPPSPATRSRRPYRHYKIINQPPPPTPC--STDICD---------ESDSNYTSKSNSNN 1600
                         ..:..:|..||...|  .:.:||         :.:.|.|.::.|.|
Human  2951 -------------SEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSEN 2996

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 12/38 (32%)
NHL 168..503 CDD:302697 123/361 (34%)
NHL repeat 172..237 CDD:271320 26/66 (39%)
LY 252..293 CDD:214531 13/40 (33%)
NHL repeat 261..298 CDD:271320 12/36 (33%)
NHL repeat 303..339 CDD:271320 11/48 (23%)
NHL repeat 341..419 CDD:271320 32/81 (40%)
NHL repeat 428..476 CDD:271320 13/47 (28%)
LY 472..511 CDD:214531 17/41 (41%)
NHL repeat 477..503 CDD:271320 13/26 (50%)
Ldl_recept_b 534..573 CDD:278487 10/41 (24%)
LY 558..599 CDD:214531 14/40 (35%)
LY 600..641 CDD:214531 14/40 (35%)
FXa_inhibition 668..703 CDD:291342 11/35 (31%)
LY 739..773 CDD:214531 12/38 (32%)
LY 776..818 CDD:214531 18/45 (40%)
LY 819..860 CDD:214531 14/41 (34%)
FXa_inhibition 973..1010 CDD:291342 18/36 (50%)
LY 1122..1164 CDD:214531 15/41 (37%)
FXa_inhibition 1273..1313 CDD:291342 13/50 (26%)
LDLa 1319..1362 CDD:238060 15/46 (33%)
LDLa 1365..1399 CDD:238060 13/33 (39%)
LDLa 1399..1433 CDD:197566 13/39 (33%)
LRP2NP_004516.2 LDLa 28..62 CDD:238060
LDLa 108..142 CDD:238060
LDLa 149..179 CDD:238060
LDLa 183..217 CDD:238060
LDLa 222..256 CDD:238060
LDLa 266..300 CDD:238060
LY 415..457 CDD:214531
LDL-receptor class B 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 436..478
LY 461..501 CDD:214531
LDL-receptor class B 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 479..521
LY 503..548 CDD:214531
LDL-receptor class B 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 522..568
LY 551..591 CDD:214531
LDL-receptor class B 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 569..613
FXa_inhibition 663..704 CDD:291342
LDL-receptor class B 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 753..795
LY 776..818 CDD:214531
LDL-receptor class B 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 796..837
LDL-receptor class B 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 838..881
Ldl_recept_b 838..878 CDD:278487
LY 864..904 CDD:214531
LDL-receptor class B 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 882..925
FXa_inhibition 981..1013 CDD:291342
LDLa 1026..1060 CDD:238060
LDLa 1067..1101 CDD:238060
LDLa 1109..1143 CDD:238060
LDLa 1149..1183 CDD:238060
LDLa 1187..1222 CDD:238060
LDLa 1230..1264 CDD:238060
LDLa 1271..1305 CDD:238060
LDLa 1311..1344 CDD:197566
FXa_inhibition 1353..1388 CDD:291342
EGF_CA 1390..1429 CDD:214542
LY 1461..1500 CDD:214531 8/46 (17%)
LDL-receptor class B 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1478..1520 9/49 (18%)
LY 1501..1543 CDD:214531 14/41 (34%)
LDL-receptor class B 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1521..1563 16/41 (39%)
LY 1545..1589 CDD:214531 22/45 (49%)
LDL-receptor class B 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1566..1609 23/44 (52%)
LY 1591..1632 CDD:214531 13/40 (33%)
LDL-receptor class B 12. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1610..1654 10/43 (23%)
LDL-receptor class B 13. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1655..1695 9/51 (18%)
LDL-receptor class B 14. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1790..1832 16/42 (38%)
LDL-receptor class B 15. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1833..1882 19/48 (40%)
LDL-receptor class B 16. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1883..1930 14/46 (30%)
Ldl_recept_b 1883..1927 CDD:278487 11/43 (26%)
LY 1911..1953 CDD:214531 14/41 (34%)
LDL-receptor class B 17. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1931..1972 12/41 (29%)
LDL-receptor class B 18. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1973..2013 19/39 (49%)
FXa_inhibition 2022..2058 CDD:291342 11/35 (31%)
NHL 2091..2300 CDD:302697 65/211 (31%)
YncE 2092..>2285 CDD:225926 62/195 (32%)
NHL repeat 2097..2142 CDD:271320 15/44 (34%)
LDL-receptor class B 19. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2107..2156 19/48 (40%)
NHL repeat 2147..2186 CDD:271320 18/38 (47%)
LDL-receptor class B 20. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2157..2201 17/43 (40%)
NHL repeat 2192..2231 CDD:271320 10/38 (26%)
LDL-receptor class B 21. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2202..2245 10/42 (24%)
NHL repeat 2235..2275 CDD:271320 9/42 (21%)
LDL-receptor class B 22. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2246..2289 10/45 (22%)
FXa_inhibition 2346..2382 CDD:291342 18/36 (50%)
LDL-receptor class B 23. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2431..2477 8/45 (18%)
LY 2459..2500 CDD:214531 8/40 (20%)
LDL-receptor class B 24. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2478..2518 10/41 (24%)
LY 2500..2542 CDD:214531 15/43 (35%)
LDL-receptor class B 25. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2519..2562 15/42 (36%)
LY 2545..2585 CDD:214531 10/39 (26%)
LDL-receptor class B 26. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2563..2604 8/41 (20%)
LDL-receptor class B 27. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2605..2646 11/50 (22%)
FXa_inhibition 2655..2692 CDD:291342 12/42 (29%)
LDLa 2700..2732 CDD:238060 17/46 (37%)
LDLa 2741..2775 CDD:238060 13/33 (39%)
LDLa 2784..2817 CDD:238060 13/33 (39%)
LDLa 2821..2854 CDD:197566 7/57 (12%)
Ldl_recept_a 2863..2895 CDD:278486 7/31 (23%)
LDLa 2905..2937 CDD:197566 4/31 (13%)
LDLa 2948..2988 CDD:238060 7/59 (12%)
LDLa 2993..3027 CDD:238060 2/4 (50%)
LDLa 3031..3063 CDD:197566
LDLa 3075..3109 CDD:238060
cEGF 3132..3155 CDD:289433
vWFA <3147..3190 CDD:294047
LY 3219..3260 CDD:214531
LDL-receptor class B 28. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3239..3281
LY 3262..3304 CDD:214531
Ldl_recept_b 3282..3329 CDD:278487
LDL-receptor class B 29. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3282..3324
LDL-receptor class B 30. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3333..3376
Ldl_recept_b 3333..3373 CDD:278487
LY 3358..3399 CDD:214531
LDL-receptor class B 31. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3377..3419
LY <3408..3441 CDD:214531
LDL-receptor class B 32. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3420..3460
FXa_inhibition 3469..>3498 CDD:291342
LDLa 3512..3544 CDD:197566
LDLa 3553..3584 CDD:197566
LDLa 3594..3626 CDD:238060
LDLa 3634..3666 CDD:197566
LDLa 3682..3714 CDD:238060
LDLa 3719..3754 CDD:238060
LDLa 3759..3793 CDD:238060
LDLa 3798..3832 CDD:238060
LDLa 3885..3915 CDD:197566
LDLa 3928..3962 CDD:238060
EGF_CA 4007..4047 CDD:214542
LY 4141..4176 CDD:214531
LDL-receptor class B 33. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4154..4196
LDL-receptor class B 34. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4197..4240
Ldl_recept_b 4197..4237 CDD:278487
LY 4222..4264 CDD:214531
LDL-receptor class B 35. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4242..4283
SH3-binding. /evidence=ECO:0000255 4453..4462
PxLPxI/L motif 1, mediates interaction with ANKRA2. /evidence=ECO:0000250|UniProtKB:P98158 4456..4461
PxLPxI/L motif 2, mediates interaction with ANKRA2. /evidence=ECO:0000250|UniProtKB:P98158 4459..4464
Endocytosis signal. /evidence=ECO:0000255 4521..4526
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4550..4574
Interaction with DAB2. /evidence=ECO:0000269|PubMed:10769163 4589..4602
NPXY motif 4595..4598
SH2-binding. /evidence=ECO:0000255 4598..4601
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4601..4655
SH3-binding. /evidence=ECO:0000255 4611..4622
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155335
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.740

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