DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment arr and ldlra

DIOPT Version :9

Sequence 1:	NP_524737.2	Gene:	arr / 44279	FlyBaseID:	FBgn0000119	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	NP_001025454.1	Gene:	ldlra / 387529	ZFINID:	ZDB-GENE-031217-1	Length:	911	Species:	Danio rerio

Alignment Length:	433	Identity:	128/433 - (29%)
Similarity:	193/433 - (44%)	Gaps:	109/433 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 ELIDTPKAPN---SVRAW-DPSLQPYEDNPCAHNNGNCSHLCLLATNSQ--GFSCACPTGVKLI- 392
            |.|...|..|   ..|.| |..|:..:.|.|.:|||.|||:|    |..  |:.|.||||.:|:
Zfish   284 ECISMEKVCNKQRDCRDWSDEPLRECDSNECLYNNGGCSHIC----NDLKIGYECLCPTGFRLVD 344

  Fly   393 -----SANTCAN-----------------------------------GSQEMMFIVQRTQISKIS 417
                 ..:.|||                                   |:...:|...|.::.|::
Zfish   345 KRRCEDIDECANPDTCSQICVNQMGSYKCECEDGYQMDPASKACKAIGTIAYLFFTNRHEVRKMT 409

  Fly   418 LDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDV---ETYTIKRAHADGTGVTDFVTSEVRHP 479
            ||..:| |..:|  ::|..:|:|.:.....|||||:   :.|:|:.|
Zfish   410 LDRSEY-IRVIP--RLKNVVALDMNIASRDIYWSDLSLKKIYSIRGA------------------ 453

  Fly   480 DGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERKP 544
                                 |.|...||:.||.|..|:|.:||||.|.|...:|||:||. ...
Zfish   454 ---------------------ISVATADGSRRKTLFKENLAKPRAIVVDPIKNFMFWTDWG-TPA 496

  Fly   545 KVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISD--NL 607
            |:|::.|:|.:|..||::::.|||||.||:..:.:||.|.|...:...::.|.|||.:|.|  .|
Zfish   497 KIEKSGLNGVDRSTLVADDIVWPNGITLDLLTERLYWVDSKLHTLSSISVQGDGRRTLIIDQGKL 561

  Fly   608 KHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQY--PDLMGLKVTRLREVRGQNACAV 670
            .|...|::.::.::|||....:|..|:::||.:...|.:..  |:.:.| ...|::..|.|.|.:
Zfish   562 AHPLSLTVFEEKVFWTDVSNNAILSANRVTGGDITKVAEHLSSPEDIVL-FHNLKQPTGINWCRI 625

  Fly   671 RNGGCSHLCLNRPR------DYVCRCAIDYELANDKRTCVVPA 707
            .||||..|||..|:      .|.|.|..:..||.|.|.| |||
Zfish   626 NNGGCEFLCLAAPQINRFSPKYTCACPDNMMLARDMRKC-VPA 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arr	NP_524737.2	LY	162..201	CDD:214531
		NHL	168..503	CDD:302697	49/217 (23%)
		NHL repeat	172..237	CDD:271320
		LY	252..293	CDD:214531
		NHL repeat	261..298	CDD:271320
		NHL repeat	303..339	CDD:271320	2/3 (67%)
		NHL repeat	341..419	CDD:271320	30/124 (24%)
		NHL repeat	428..476	CDD:271320	12/50 (24%)
		LY	472..511	CDD:214531	4/38 (11%)
		NHL repeat	477..503	CDD:271320	1/25 (4%)
		Ldl_recept_b	534..573	CDD:278487	17/38 (45%)
		LY	558..599	CDD:214531	14/40 (35%)
		LY	600..641	CDD:214531	13/42 (31%)
		FXa_inhibition	668..703	CDD:291342	16/40 (40%)
		LY	739..773	CDD:214531
		LY	776..818	CDD:214531
		LY	819..860	CDD:214531
		FXa_inhibition	973..1010	CDD:291342
		LY	1122..1164	CDD:214531
		FXa_inhibition	1273..1313	CDD:291342
		LDLa	1319..1362	CDD:238060
		LDLa	1365..1399	CDD:238060
		LDLa	1399..1433	CDD:197566
ldlra	NP_001025454.1	LDLa	23..55	CDD:197566
		Ldl_recept_a	63..101	CDD:365841
		LDLa	106..140	CDD:238060
		LDLa	144..176	CDD:197566
		Ldl_recept_a	192..227	CDD:365841
		Ldl_recept_a	231..266	CDD:365841
		LDLa	274..304	CDD:238060	6/19 (32%)
		FXa_inhibition	314..348	CDD:373209	16/37 (43%)
		EGF_CA	350..380	CDD:214542	3/29 (10%)
		Ldl_recept_b	437..481	CDD:278487	21/82 (26%)
		Ldl_recept_b	485..525	CDD:278487	17/40 (43%)
		LY	510..551	CDD:214531	14/40 (35%)
		Ldl_recept_b	572..611	CDD:278487	10/39 (26%)
		FXa_inhibition	623..664	CDD:373209	16/40 (40%)
		PHA03247	<666..808	CDD:223021	2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590480
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.830